A5079731794- Spondyloarthritis Studies and Treatments
- Bone and Joint Diseases
- Rheumatoid Arthritis Research and Therapies
- Spine and Intervertebral Disc Pathology
- Gastric Cancer Management and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Hip disorders and treatments
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Osteoarthritis Treatment and Mechanisms
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal Tumor Research and Treatment
- Inflammasome and immune disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Musculoskeletal synovial abnormalities and treatments
- Total Knee Arthroplasty Outcomes
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Scoliosis diagnosis and treatment
University of Alberta
2016-2025
Humboldt-Universität zu Berlin
2024
Freie Universität Berlin
2024
Sheba Medical Center
2017-2024
University College London Hospitals NHS Foundation Trust
2024
National Institute for Health Research
2024
Tel Aviv University
2017-2024
Charité - Universitätsmedizin Berlin
2017-2024
Ghent University Hospital
2019-2022
University of South Alabama
2022
Abstract Objective To develop a feasible magnetic resonance imaging (MRI)–based scoring system for sacroiliac joint inflammation in patients with ankylosing spondylitis (AS) that requires minimal scan time, does not require contrast enhancement, evaluates lesions separately at each articular surface, and limits the number of images are scored. Methods A method based on assessment increased signal denoting bone marrow edema T2‐weighted STIR sequences was used. MRI films were assessed blindly...
Population-based screening for early detection and treatment of colorectal cancer (CRC) precursor lesions, using evidence-based methods, can be effective in populations with a significant burden the disease provided services are high quality. Multidisciplinary, guidelines quality assurance CRC diagnosis have been developed by experts project co-financed European Union. The 450-page were published book format Commission 2010. They include 10 chapters over 250 recommendations, individually...
Abstract Objective To determine whether a vertebral corner that demonstrates an active inflammatory lesion (CIL) on magnetic resonance imaging (MRI) in patients with ankylosing spondylitis (AS) is more likely to evolve into de novo syndesmophyte visible plain radiography than no inflammation MRI. Methods MRI scans and radiographs were obtained for 29 recruited randomized placebo‐controlled trials of anti–tumor necrosis factor α (anti‐TNFα) therapy. was conducted at baseline, 12 or 24 weeks...
Abstract Objective To systematically assess the diagnostic utility of magnetic resonance imaging (MRI) to differentiate patients with spondylarthritis (SpA) from nonspecific back pain and healthy volunteers, using a standardized evaluation MR images sacroiliac joints. Methods Five readers blinded diagnoses independently assessed MRI scans (T1‐weighted STIR sequences) joints obtained 187 subjects: 75 ankylosing spondylitis (AS; symptom duration ≤10 years), 27 preradiographic inflammatory...
Objectives The Assessment of SpondyloArthritis international Society (ASAS) MRI working group (WG) was convened to generate a consensus update on standardised definitions for lesions in the sacroiliac joint (SIJ) patients with spondyloarthritis (SpA), and conduct preliminary validation. Methods literature pertaining these lesion discussed at three meetings group. 25 investigators (20 rheumatologists, 5 radiologists) determined which should be retained or required revision, new definition....
Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts a project coordinated the International Agency Research on Cancer. The full guideline document covers entire process of population-based screening. It consists 10 chapters over 250 recommendations, graded according to strength recommendation supporting evidence. 450-page extensive evidence base published European Commission. chapter colonoscopic...
Abstract Objective To compare the efficacy of adalimumab versus placebo in reducing spinal and sacroiliac (SI) joint inflammation, by magnetic resonance imaging (MRI) patients with active ankylosing spondylitis (AS). Methods This was a randomized, multicenter, double‐blind, placebo‐controlled study. Patients (n = 82) received 40 mg or every other week during an initial 24‐week double‐blind period. MRIs both spine SI joints were obtained at baseline, 12, 52. Spinal inflammation measured using...
The purpose of introducing optical electronics into video endoscopes is to improve the accuracy diagnosis through image processing and digital technology. Narrow-band imaging (NBI), one most recent techniques, involves use interference filters illuminate target in narrowed red, green blue (R/G/B) bands spectrum. This results different images at distinct levels mucosa increases contrast between epithelial surface subjacent vascular network. NBI can be combined with magnifying endoscopy an...
To develop a feasible magnetic resonance imaging (MRI)-based scoring system for spinal inflammation in patients with spondylarthropathy that requires minimal scan time, does not require contrast enhancement, evaluates the extent of lesions 3 dimensional planes, and limits number vertebral levels are scored because MRI demonstrates characteristic inflammatory spine ankylosing spondylitis (AS) prior to development typical features on plain radiographic.Our method was based entirely assessment...
Although MRI data supports a link between spinal inflammation and formation of new bone in ankylosing spondylitis, anti-tumour necrosis factor α therapies have not been shown to prevent formation. The authors aimed demonstrate that while acute lesions resolve completely, more advanced lesions, characterised by evidence reparation, are associated with formation.MRI scans were performed at baseline, 12 52 weeks 76 spondylitis patients recruited placebo-controlled trial adalimumab therapy. New...
OBJECTIVE:: To systematically assess the diagnostic utility of MRI to differentiate spondyloarthritis (SpA) patients from with non-specific back pain (NSBP) and healthy volunteers using a standardized evaluation MR images sacroiliac joints (SIJ). METHODS:: Five readers blinded patient diagnosis independently assessed scans (T1-weighted STIR sequences) SIJ 187 subjects: 75 AS (symptom duration </=10 years); 27 pre-radiographic inflammatory (IBP) (mean symptom 29 months); 26 NSBP 59 controls...
Focal fat infiltration is frequently visible on magnetic resonance imaging (MRI) of the spine in patients with ankylosing spondylitis (AS) and likely reflects postinflammatory tissue metaplasia. To support concept coupling between inflammation new bone formation, we tested hypothesis that focal at a vertebral corner more to evolve into de novo syndesmophyte.MRI scans were obtained baseline radiographs 2 years 100 AS from cohorts: clinical trial cohort (n = 38) an observational 62). In...
Abstract Objective To determine the efficacy of fluoroscopically guided corticosteroid injection for hip osteoarthritis (OA) in a randomized, double‐blind, placebo‐controlled trial. Methods Fifty‐two patients with symptomatic OA were randomly allocated to receive placebo (10 mg bipuvicaine, 2 ml saline) (n = 21) or treatment 40 triamcinolone hexacetonide) 31). Patients followed up 1, 2, 3, and 6 months. The primary outcome measure was pain improvement response, defined as 20% decrease...
Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts a project coordinated the International Agency Research on Cancer. The full guideline document covers entire process of population-based screening. It consists 10 chapters over 250 recommendations, graded according to strength recommendation supporting evidence. 450-page extensive evidence base published European Commission. chapter endoscopy includes...
Objective. There is an unmet need for reliable assessment of structural progression in the sacroiliac joints (SIJ) patients with spondyloarthritis (SpA), but radiography unreliable and lacks responsiveness. We aimed to develop validate a new scoring method lesions based on magnetic resonance imaging (MRI), Spondyloarthritis Research Consortium Canada (SPARCC) SIJ Structural Score (SSS). Methods. The SSS T1-weighted spin echo MRI, validated lesion definitions, slice selection according...
Fat metaplasia in bone marrow on T1-weighted magnetic resonance imaging (MRI) scans may develop after resolution of inflammation patients with ankylosing spondylitis (AS) and predict new formation the spine. Similar tissue, termed backfill, also fill areas excavated sacroiliac (SI) joints reflect tissue repair at sites erosions. The purpose this study was to test our hypothesis that SI joint ankylosis develops following erosions characterized by fat is a key intermediary step pathway.We used...
Objective To assess the incremental diagnostic value of spine MRI evaluated separately from and combined with sacroiliac joint (SIJ) in non-radiographic axial spondyloarthritis (nr-axSpA) compared SIJ alone. Methods The study sample comprised two independent cohorts A/B 130 consecutive patients aged ≤50 years back pain, newly referred to university clinics, 20 healthy controls. Patients were classified according clinical examination pelvic radiographs as having nr-axSpA (n=50), ankylosing...
<h3>Objective</h3> To determine candidate lesion-based criteria for a positive sacroiliac joint (SIJ) MRI based on bone marrow oedema (BMO) and/or erosion in non-radiographic axial spondyloarthritis (nr-axSpA); to compare the performance of with global evaluation by expert readers. <h3>Methods</h3> Two independent cohorts A/B 69/88 consecutive patients back pain aged ≤50 years, median symptom duration 1.3/10.0 were referred suspected SpA (A) or acute anterior uveitis plus (B). Patients...