A5056121788- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Molecular Biology Techniques and Applications
- Anorectal Disease Treatments and Outcomes
- AI in cancer detection
- Prenatal Screening and Diagnostics
- Gut microbiota and health
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Gastrointestinal disorders and treatments
- Genomic variations and chromosomal abnormalities
- Cell Image Analysis Techniques
University of Leeds
2016-2025
St James's University Hospital
2016-2025
NIHR Leeds Musculoskeletal Biomedical Research Unit
2024
Leeds Teaching Hospitals NHS Trust
2002-2024
University of St. Gallen
1991-2023
Winterthur Museum Garden and Library
1991-2023
University of Oxford
2004-2023
Wellcome Trust
2007-2023
University of Birmingham
2011-2023
Wellcome Sanger Institute
2020
The aim of the current study is to report long-term outcomes after laparoscopic-assisted surgery compared with conventional open within context UK MRC CLASICC trial. Results from randomized trials have indicated that laparoscopic for colon cancer as effective in short term. Few data are available on rectal cancer, and survival recurrence now required.The United Kingdom Medical Research Council Conventional versus Laparoscopic-Assisted Surgery Colorectal Cancer (UK CLASICC; clinical number...
<h3>Importance</h3> Robotic rectal cancer surgery is gaining popularity, but limited data are available regarding safety and efficacy. <h3>Objective</h3> To compare robotic-assisted vs conventional laparoscopic for risk of conversion to open laparotomy among patients undergoing resection cancer. <h3>Design, Setting, Participants</h3> Randomized clinical trial comparing 471 with adenocarcinoma suitable curative conducted at 29 sites across 10 countries, including 40 surgeons. Recruitment was...
The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open for colorectal cancer. results 5-year follow-up analysis are presented.Five-year outcomes were analysed included overall disease-free survival, local, distant wound/port-site recurrences. Two exploratory analyses performed to evaluate effect age (70 years or less, more than 70 years) on survival between two groups, learning curve.No differences found...
PURPOSE: Quality assessment and assurance are important issues in modern health care. For the evaluation of surgical procedures, there indirect parameters such as complication, recurrence, survival rates. These limited value for individual surgeon, is an obvious need direct parameters. We have evaluated criteria by which pathologists can judge quality or completeness resection specimen a randomized trial rectal cancer. PATIENTS AND METHODS: The pathology reports all patients entered onto...
Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients colorectal cancer were invited to provide that data in a schematized format for inclusion collaborative database called RASCAL (The in-colorectal-cancer group). Our results from 2721 such have been presented previously first time any common cancer, showed conclusively different gene mutations impacts on outcome, even when occur at same site genome. To explore effect Ki-ras stages...
The plane of surgery in colonic cancer has been linked to patient outcome although the optimal extent mesenteric resection is still unclear. Surgeons Erlangen, Germany, routinely perform complete mesocolic excision (CME) with central vascular ligation (CVL) and report 5-year survivals higher than 89%. We aimed further investigate importance CME CVL for by comparison a series standard specimens.The fresh photographs 49 specimens from Erlangen 40 Leeds, United Kingdom, primary adenocarcinoma...
Objective To analyze the potential variability in rates of circumferential resection margin (CRM) involvement between different surgeons and time periods to determine suitability using CRM status as an immediate predictor outcome after rectal cancer surgery. Summary Background Data After disease stage has been taken into account, survival shown be very variable institutions. One major factors influencing is local recurrence, this turn strongly related inadequate tumor excision, particularly...
Abstract Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR) status its relation to BRAF mutation (BRAFMT) in metastatic colorectal cancer (mCRC). Experimental Design: A pooled analysis four phase III studies first-line treatment mCRC (CAIRO, CAIRO2, COIN, FOCUS) was performed. Primary outcome parameter hazard ratio (HR) for median progression-free survival (PFS) overall (OS) MMR BRAF. For analysis, Cox regression performed on individual patient data. Results:...
Abstract Background Laparoscopic resection is used widely in the management of colorectal cancer; however, data on long-term outcomes, particularly those related to rectal cancer, are limited. The results follow-up UK Medical Research Council trial laparoscopically assisted versus open surgery for cancer presented. Methods A total 794 patients from 27 centres were randomized laparoscopic or a 2:1 ratio between 1996 and 2002. Long-term analysed determine differences survival outcomes...
To assess magnetic resonance imaging (MRI) and pathologic staging after neoadjuvant therapy for rectal cancer in a prospectively enrolled, multicenter study.In prospective cohort study, 111 patients who had treated by were assessed response MRI pathology T, N circumferential resection margin (CRM) status. Tumor regression grade (TRG) was also MRI. Overall survival (OS) estimated using the Kaplan-Meier product-limit method, Cox proportional hazards models used to determine associations...
Purpose It is uncertain whether modest benefits from adjuvant chemotherapy in stage II colorectal cancer justify the toxicity, cost, and inconvenience. We investigated usefulness of defective mismatch repair (dMMR), BRAF, KRAS mutations predicting tumor recurrence sensitivity to chemotherapy. Patients Methods Immunohistochemistry for dMMR pyrosequencing KRAS/BRAF were performed 1,913 patients randomly assigned between fluorouracil folinic acid no Quick Simple Reliable (QUASAR) trial. Results...
To assess local recurrence, disease-free survival, and overall survival in magnetic resonance imaging (MRI)-predicted good prognosis tumors treated by surgery alone.The MERCURY study reported that high-resolution MRI can accurately stage rectal cancer. The routine policy most centers involved the was primary alone MRI-predicted II or less "good prognosis" III with selective avoidance of neoadjuvant therapy.Data were collected prospectively on all patients included who staged as MRI-defined...
Despite the major improvements that have been made due to total mesorectal excision (TME), low rectal cancer still remains a challenge.By investigating prospective randomized trial in which surgeons had undergone training TME factors responsible for poor outcome were determined and new method assessing quality of surgery was tested.Survival differed greatly between abdominoperineal resection (APR) anterior (AR; 38.5% v 57.6%, P = .008). Low carcinomas higher frequency circumferential margin...
Activating mutation of the KRAS oncogene is an established predictive biomarker for resistance to anti-epidermal growth factor receptor (anti-EGFR) therapies in advanced colorectal cancer (aCRC). We wanted determine whether and/or BRAF also a other aCRC therapies.The Medical Research Council Fluorouracil, Oxaliplatin and Irinotecan: Use Sequencing (MRC FOCUS) trial compared treatment sequences including first-line fluorouracil (FU), FU/irinotecan or FU/oxaliplatin aCRC. Tumor blocks were...
The prognostic relevance of preoperative high-resolution magnetic resonance imaging (MRI) assessment circumferential resection margin (CRM) involvement is unknown. This follow-up study 374 patients with rectal cancer reports the relationship between MRI CRM staging, American Joint Committee on Cancer (AJCC) TNM stage, and clinical variables overall survival (OS), disease-free (DFS), time to local recurrence (LR).Patients underwent protocol pelvic MRI. Tumor distance mesorectal fascia ≤ 1 mm...
Wnt family members are critical to many developmental processes, and components of the signaling pathway have been linked tumorigenesis in familial sporadic colon carcinomas. Here we report identification two genes, WISP-1 WISP-2, that up-regulated mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not Wnt-4. Together with a third related gene, WISP-3, these proteins define subfamily connective tissue growth factor family. Two distinct systems demonstrated WISP induction be...