A5072103457- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Colorectal Cancer Screening and Detection
- Enhanced Recovery After Surgery
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Nanoplatforms for cancer theranostics
- Global Health and Surgery
- Colorectal Cancer Treatments and Studies
- Minimally Invasive Surgical Techniques
- Anatomy and Medical Technology
- Colorectal and Anal Carcinomas
- Hernia repair and management
- Vasculitis and related conditions
- Photodynamic Therapy Research Studies
- Cancer Research and Treatments
- Diversity and Career in Medicine
- Hemodynamic Monitoring and Therapy
- Abdominal Surgery and Complications
- Cancer, Hypoxia, and Metabolism
- Intestinal and Peritoneal Adhesions
- Health Systems, Economic Evaluations, Quality of Life
St James's University Hospital
2016-2025
Leeds Teaching Hospitals NHS Trust
2014-2025
University of Leeds
2016-2025
University of Cambridge
2014-2024
University of Bristol
2024
Chapel Allerton Hospital
2024
University of Birmingham
2023
Royal College of Surgeons of England
2023
The Honourable Society of Lincoln's Inn
2023
Institute of Biomedical Science
2022
The aim of the current study is to report long-term outcomes after laparoscopic-assisted surgery compared with conventional open within context UK MRC CLASICC trial. Results from randomized trials have indicated that laparoscopic for colon cancer as effective in short term. Few data are available on rectal cancer, and survival recurrence now required.The United Kingdom Medical Research Council Conventional versus Laparoscopic-Assisted Surgery Colorectal Cancer (UK CLASICC; clinical number...
<h3>Importance</h3> Robotic rectal cancer surgery is gaining popularity, but limited data are available regarding safety and efficacy. <h3>Objective</h3> To compare robotic-assisted vs conventional laparoscopic for risk of conversion to open laparotomy among patients undergoing resection cancer. <h3>Design, Setting, Participants</h3> Randomized clinical trial comparing 471 with adenocarcinoma suitable curative conducted at 29 sites across 10 countries, including 40 surgeons. Recruitment was...
The UK Medical Research Council CLASICC trial assessed the safety and efficacy of laparoscopically assisted surgery in comparison with open for colorectal cancer. results 5-year follow-up analysis are presented.Five-year outcomes were analysed included overall disease-free survival, local, distant wound/port-site recurrences. Two exploratory analyses performed to evaluate effect age (70 years or less, more than 70 years) on survival between two groups, learning curve.No differences found...
Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis. Mepolizumab, anti–interleukin-5 monoclonal antibody, reduces blood eosinophil counts and may have value in the treatment of polyangiitis.
Abstract Background Aggressive therapeutic regimens have been advocated for the treatment of peritoneal carcinomatosis from colorectal cancer. It is essential to understand clinical and histological features that govern natural history this condition if efficacies novel approaches are be assessed adequately. Methods A database 3019 cancers was used identify patients with synchronous carcinomatosis, who developed metachronous those without carcinomatosis. Clinical, survival data groups were...
Abstract Background Laparoscopic resection is used widely in the management of colorectal cancer; however, data on long-term outcomes, particularly those related to rectal cancer, are limited. The results follow-up UK Medical Research Council trial laparoscopically assisted versus open surgery for cancer presented. Methods A total 794 patients from 27 centres were randomized laparoscopic or a 2:1 ratio between 1996 and 2002. Long-term analysed determine differences survival outcomes...
Abstract Background Bladder and sexual dysfunction are recognized complications of mesorectal resection. Their incidence following laparoscopic surgery is unknown. Methods function were assessed in patients who had undergone rectal, open rectal or colonic resection as part the UK Medical Research Council Conventional versus Laparoscopic-Assisted Surgery In Colorectal Cancer (CLASICC) trial, using International Prostatic Symptom Score, Index Erectile Function Female Sexual Index. bladder data...
Abstract Background Bladder and sexual dysfunction, secondary to pelvic nerve injury, are recognized complications of rectal resection. This study investigated the frequency these following laparoscopically assisted conventional open mesorectal resection for cancer. Methods A total 170 patients with cancer was identified from a previous randomized trial laparoscopic versus retrospective analysis bladder function before after operation performed by means postal questionnaires telephone...
To investigate the effect that complications have on patients' long-term quality of life (QoL) after curative colorectal cancer surgery.Colorectal surgery is a high risk, with approximately 1 in 3 patients suffering complication. The consequences postoperative are important but poorly been documented.The MRC-CLASICC trial (laparoscopic-assisted vs open for cancer) included prospective evaluation QoL using validated scoring questionnaires: EORTC QLQ-C30/CR38 and EQ5D. These were used to...
Abstract An international working party was convened in Rome, Italy on 16–17 June, 2005, with the purpose of developing a consensus application circular stapling instrument to treatment certain rectal conditions, so‐called Stapled Transanal Rectal Resection (STARR). Since procedure has been submitted only limited objective analysis it felt prudent hold meeting interested individuals for evaluating current status and make conclusions recommendations concerning applicability this new approach.
Cancer cells are highly dependent on glycolysis. Our aim was to determine if switching metabolism from glycolysis towards mitochondrial respiration would reduce growth preferentially in colorectal cancer over normal cells, and examine the underlying mechanisms.
Abstract Background This study investigated adhesive intestinal obstruction (AIO) and incisional hernia (IH) in patients undergoing laparoscopically assisted open surgery for colorectal cancer. Methods In a case-note review of randomized to the Medical Research Council's Conventional versus Laparoscopic-Assisted Surgery Colorectal Cancer (CLASICC) trial, primary key secondary endpoints were AIO IH admission rates respectively. Results Of 411 patients, 11 admitted AIO: four (3·1 per cent) 131...
PURPOSE: Stapled transanal rectal resection is advocated for the treatment of obstructed defecation syndrome. Supporting evidence its safety and effectiveness has been lacking. To address this, European Transanal Rectal Resection Registry was initiated in January 2006. This study designed to analyze 12-month postoperative outcomes this procedure using data collected registry. METHODS: On May 17, 2008, were downloaded from perform an analysis outcomes. Data had prospectively on (symptom...
Colorectal cancer-specific biomarkers have been used as molecular targets for fluorescent intra-operative imaging, targeted PET/MRI, and selective cytotoxic drug delivery yet the selection of is rarely evidence-based. We evaluated sensitivities specificites four most commonly markers: carcinoembryonic antigen (CEA), tumour-associated glycoprotein-72 (TAG-72), folate receptor-α (FRα) Epithelial growth factor receptor (EGFR).Marker expression was semi-quantitatively in matched mucosal...
New editions of the TNM staging system for colorectal cancer have been subject to extensive criticism. In current study, we evaluate each edition and analyze stage migration caused by different versions.Two independent test populations were used: participants derived from a randomized surgical trial United Kingdom (n = 455) patients population-based series Sweden 505). All slides these patient cases reviewed with special attention presence tumor deposits. Tumor deposits classified according...