A5081984435- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- Trauma and Emergency Care Studies
- Spinal Fractures and Fixation Techniques
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Emergency and Acute Care Studies
- Traumatic Brain Injury Research
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Nerve Injury and Rehabilitation
- Cerebrovascular and Carotid Artery Diseases
- Pressure Ulcer Prevention and Management
- Stroke Rehabilitation and Recovery
- Trauma Management and Diagnosis
- Medical Imaging and Analysis
- Bone and Joint Diseases
- Cardiac Arrest and Resuscitation
- Hip disorders and treatments
- Neurobiology of Language and Bilingualism
- Wound Healing and Treatments
- Spine and Intervertebral Disc Pathology
- Pelvic floor disorders treatments
- Scoliosis diagnosis and treatment
- Spinal Hematomas and Complications
Praxis Spinal Cord Institute
2013-2021
University of Toronto
2020
University of Saskatchewan
2020
University of British Columbia
2014-2020
Dalhousie University
2020
McMaster University
2020
Université Laval
2020
Australian Spinal Research Foundation
2020
University of Alberta
2020
Spinal Research
2020
To determine the influence of time from injury to surgery on neurological recovery and length stay (LOS) in an observational cohort individuals with traumatic spinal cord (tSCI), we analyzed baseline follow-up motor scores participants Rick Hansen Spinal Cord Injury Registry specifically assess effect early (less than 24 h injury) surgical procedure LOS. One thousand four hundred ten patients who sustained acute tSCIs American Association Impairment Scale (AIS) grades A, B, C, or D were...
Background and Purpose— Several methods are available to assess the magnetic resonance perfusion lesion in acute ischemic stroke. We tested 10 of these compare sizes relation clinical scores final infarct extent. Methods— recruited patients with stroke, performed diffusion- perfusion-weighted imaging, recorded stroke severity at baseline, size on T2-weighted imaging ≥1 month, Rankin Scale score 3 months. calculated parameters (6 mean transit time, MTT; cerebral blood flow; 1 volume; 7...
In prior analyses of the effectiveness methylprednisolone for treatment patients with acute traumatic spinal cord injuries (TSCIs), prognostic importance patients' neurological levels injury and their baseline severity impairment has not been considered. Our objective was to determine whether improved motor recovery among participants in Rick Hansen Spinal Cord Injury Registry (RHSCIR). We identified RHSCIR who received according Second National Study (NASCIS-II) protocol used propensity...
To analyze relations among injury, demographic, and environmental factors on function, health-related quality of life (HRQoL), satisfaction in individuals with traumatic spinal cord injury (SCI).Prospective observational registry cohort study.Specialized acute rehabilitation SCI centers.Participants (N=340) from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) who were prospectively recruited 2004 to 2014 included. The model participants 79.1% men, a mean age 41.6±17.3 years. Of...
Background and Purpose— An acute mismatch on diffusion-weighted MRI (DWI) perfusion-weighted (PWI) may represent the “tissue-at-risk.” It is unclear which “semiquantitative” perfusion parameter most closely identifies final infarct volume. Methods— Acute stroke patients underwent DWI PWI (dynamic-susceptibility contrast imaging) admission (baseline), T 2 -weighted imaging (T WI) at 1 or 3 months after stroke. “Semiquantitative” mean transit time (MTT sq =first moment of concentration/time...
<b>Background: </b> MR diffusion-weighted imaging (DWI) shows acute ischemic lesions early after stroke so it might improve outcome prediction and reduce sample sizes in treatment trials. Previous studies of DWI produced conflicting results. <b>Objective: To determine whether lesion characteristics independently predict a broad range patients with stroke. <b>Methods: The authors recruited hospital-admitted all severities suspected stroke, assessed severity on the NIH Stroke Scale (NIHSS),...
Patients with pressure ulcers (PUs) report that pain is their most distressing symptom, but there are few PU prevalence studies. We sought to estimate the of unattributed area related (UPAR pain) which was defined as pain, soreness or discomfort reported by patients, on an "at risk" skin site, at a patient level.We undertook surveys in 2 large UK teaching hospital NHS Trusts (6 hospitals) and district general Trust (3 during routine annual audits. The hospitals provide secondary tertiary...
Clinical trials of therapies for acute traumatic spinal cord injury (tSCI) have failed to convincingly demonstrate efficacy in improving neurologic function. Failing acknowledge the heterogeneity these injuries and under-appreciating impact most important baseline prognostic variables likely contributes this translational failure. Our hypothesis was that neurological level severity initial (measured by American Spinal Injury Association Impairment Scale [AIS]) act jointly are major...
Background ContextTraumatic spinal cord injury (SCI) is a debilitating condition with limited treatment options for neurologic or functional recovery. The ability to predict the prognosis of walking post emerging prediction models could aid in rehabilitation strategies and reintegration into community.PurposeTo revalidate an existing clinical model independent ambulation (van Middendorp et al., 2011) using acute long-term post-injury follow-up data, investigatethe accuracy simplified...
<i>Background:</i> The biological basis of cognitive ageing is unknown. One underlying process might be disruption white matter tracts connecting cortical regions. White lesions (WML) seen on structural MRI may disrupt connections, but diffusion tensor (DT-MRI) parameters – mean diffusivity (<D>) and fractional anisotropy (FA) reflect more subtle changes in integrity. Here the relationships between WML load, DT-MRI cognition a large cohort elderly subjects with very narrow...
Older people are at increased risk of traumatic spinal cord injury from falls. We evaluated the impact older age (≥ 70 yr) on treatment decisions and outcomes. identified patients with for whom consent detailed data were available among recruited (2004-2013) any 31 acute care rehabilitation hospitals participating in Rick Hansen Spinal Cord Injury Registry. Patients assessed by group (< v. ≥ yr). The primary outcome was rate surgical treatment. used bivariate multivariate regression models...
Frailty negatively affects outcome in elective spine surgery populations. This study sought to determine the effect of frailty on patient after traumatic spinal cord injury (tSCI). Patients with tSCI were identified from our prospectively collected database 2004 2016. We examined age, admission Total Motor Score (TMS), and Modified Index (mFI) adverse events (AEs), acute length stay (LOS), in-hospital mortality, discharge destination (home vs. other). Subgroup analysis (for three age groups:...
As the incidence of traumatic spinal cord injury (tSCI) in elderly rises, clinicians are increasingly faced with difficult discussions regarding aggressiveness management, likelihood recovery, and survival. Our objective was to outline risk factors associated in-hospital mortality surgical non-surgical patients following tSCI determine those unlikely have a favorable outcome. Data from (≥ 65 years age) Canadian Rick Hansen SCI Registry 2004 2017 were analyzed using descriptive analysis....
Current prognostic tools such as the Injury Severity Score (ISS) that predict mortality following trauma do not adequately consider unique characteristics of traumatic spinal cord injury (tSCI).Our aim was to develop and validate a tool can tSCI.Retrospective review prospective cohort study.Data collected from 1245 persons with acute tSCI who were enrolled in Rick Hansen Spinal Cord Registry between 2004 2016.In-hospital 1-year tSCI.Machine learning techniques used on patient-level data...
Secondary complications of spinal cord injury (SCI) are a burden to affected individuals and the rest society. There is limited evidence economic or cost in SCI populations Canada, however, which necessary for comparative analyses decision analytic modeling possible solutions these common health problems. Comparative can inform resource allocation decisions, but outputs only as good inputs. In this article, new excess incremental costs urinary tract infection (UTI) pressure ulceration (PU)...
To investigate response shift effects in spinal cord injury (SCI) over 5 years postinjury.Prospective cohort study observed at 1, 2, and post-SCI.Specialized SCI centers.Sample included 1125, 760, 219 participants post-SCI (N = 2104). The sample was 79% men; 39% were motor/sensory complete (mean age, 44.6±18.3y).Not applicable.Patient-reported outcomes the Medical Outcomes Study 36-Item Short-Form Health Survey version 2 Life Satisfaction-11 Questionnaire. Participant latent variable scores...
Retrospective analysis of a prospective registry and surgeon survey.To identify opinion on ideal practice regarding the timing decompression/stabilization for spinal cord injury actual practice. Discrepancies in surgical barriers to surgery were explored.Canada.Patients from Rick Hansen Spinal Cord Registry (RHSCIR, 2004-2014) reviewed determine management. Following data collection, survey was distributed Canadian surgeons, asking perceived be optimal timings surgery. between responses then...
Models for predicting recovery in traumatic spinal cord injury (tSCI) patients have been developed to optimize care. Several models tSCI previously validated, yet recent findings question their accuracy, particularly whose prognoses are the least predictable.To compare independent ambulatory outcomes AIS (ASIA [American Spinal Injury Association] Impairment Scale) A, B, C, and D patients, as well B+C A+D by applying two existing logistic regression prediction models.A prospective cohort...
Some infarcts have persistently hyperintense areas on diffusion-weighted MRI (DWI) even at 1 month after stroke, whereas others become isointense to normal brain. We hypothesized that late DWI hyperintensity reflected different infarct evolution compared with were by month.We recruited patients prospectively ischemic performed and perfusion-weighted (PWI) admission, 5 days, 14 assessed functional outcome 3 months (Rankin Scale). Patient characteristics DWI/PWI values for or without "still...