A5035520250- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Geotechnical Engineering and Soil Stabilization
- Colorectal Cancer Screening and Detection
- Geotechnical Engineering and Underground Structures
- Combustion and flame dynamics
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Geotechnical Engineering and Soil Mechanics
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Turfgrass Adaptation and Management
- Combustion and Detonation Processes
- Eosinophilic Esophagitis
- Advanced MEMS and NEMS Technologies
- Computational Fluid Dynamics and Aerodynamics
- Antiplatelet Therapy and Cardiovascular Diseases
- Earthquake and Disaster Impact Studies
- Inflammatory mediators and NSAID effects
Johns Hopkins University
2024
Johns Hopkins Medicine
2024
Kagawa University
2023
Neurological Surgery
2023
Obayashi (Japan)
2006-2022
Kagawa Prefectural Central Hospital
2016
Kyoto University
1998-2015
Dokkyo University
1998-2014
Dokkyo Medical University
2007-2013
Hitachi (Japan)
2005-2009
Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients colorectal cancer were invited to provide that data in a schematized format for inclusion collaborative database called RASCAL (The in-colorectal-cancer group). Our results from 2721 such have been presented previously first time any common cancer, showed conclusively different gene mutations impacts on outcome, even when occur at same site genome. To explore effect Ki-ras stages...
Background and Aims: Differential diagnosis between non-neoplastic neoplastic lesions is very important at colonoscopy, since removal or biopsy of polyps wastes time resources. We therefore conducted a prospective study to examine whether indigo carmine dye spraying with without magnification more reliable than the conventional method for differential diagnosis. Patients Methods: 122 patients 206 10 mm smaller were recruited into this study. All detected on colonoscopy first diagnosed using...
See also: Commentaire de travail N. Kobayashi et al., pp. 701Endoscopy 2007; 39(08): 844-845DOI: 10.1055/s-0032-1308857
Although stromal cell-derived factor (SDF)-1α and its receptor CXCR4 are experimentally suggested to be involved in tumorigenicity, the clinicopathological significance of their expression human disease is not fully understood. We examined SDF-1α colorectal cancers (CRCs) related lymph nodes (LNs), investigated relationship features. Specimens 60 primary CRCs 27 LNs were immunohistochemically for only positivity but also immunostaining patterns CXCR4. The relationships between features or...
Interleukin-22 (IL-22) has been recently highlighted owing to its biological significance in the modulation of tissue responses during inflammation. However, role IL-22 carcinogenesis remained unclear. Here, we investigated pathophysiological expression gastric cancer tissues and examined mechanism by which promotes cell invasion. Human specimens were analysed immunohistochemistry for receptor 1 (IL-22R1). The effects IL-22-induced STAT3 ERK signalling on invasive ability cells using a...
Epithelial dysplasia of gall bladder is an important precancerous lesion carcinogenesis. To investigate the frequency K-ras gene mutation in carcinoma and dysplasia, codon 12 mutations were investigated by polymerase chain reaction/restriction enzyme based method following direct sequencing. Mutation was detected 59% (30 51) carcinomas, 73% (8 11) stone cases, 0% normal epithelium. There was, however, no correlation between clinicopathological factors carcinoma. occurs even at incidence...
Signal transducer and activator of transcription 3 (STAT3) signaling plays roles in inflammation-associated carcinogenesis. Regenerating gene (REG) Iα protein, an interleukin (IL)-6-inducible gene, is suggested to be involved the gastritis–gastric cancer sequence. We investigated involvement IL-6/STAT3 REG protein expression examined whether mediates anti-apoptotic effect STAT3 gastric cells. The effects on were using a small interfering RNA system element responsible for IL-6-induced...
We have proposed using laser interferometric gravitational wave detectors to search for ultralight vector and axion dark matter. Vector matter can be probed through oscillating forces on suspended mirrors, while detected via polarization rotation of beams. This paper reviews these searches with the KAGRA detector in Japan, including first KAGRA's 2020 data installation optics during upcoming 2025 observing run.
Mutations in oncogenes and tumour suppressor genes may have an important oncogenic role. Although flat type tumours been frequently detected recent years, ras p53 expressions not studied these tumours. Using a monoclonal polyclonal antibody to the p21 product, paraffin wax embedded sections of 98 colorectal (43 cases 55 polypoid tumour) were stained using immunoperoxidase technique. Staining was evaluated by light microscopic examination. Positive staining rate for 0%; type, it 60% cancer...
Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation in aberrant crypt foci (ACF), SSA/P, specimens to show close association between ACF SSA/P-cancer sequence. also evaluated prevalence number patients.ACF right-side were observed 36 patients SSA/Ps alone, 2 cancers 20 normal subjects biopsied under...
BACKGROUND Neuroendocrine cell (NEC) carcinoma is occasionally accompanied by adenocarcinoma but the relationship between these two morphologically distinct tumours unclear. Two hypotheses have arisen regarding mechanism for association of and NEC carcinoma. One that both are derived from a common multipotential epithelial stem cell. The second hypothesis arise primitive NEC, respectively. AIMS To elucidate histologically tumours, stomach duodenum. PATIENT/METHODS We present case in which...
Recently, endoscopic submucosal dissection has been recommended for the treatment of large colorectal tumors. However, use this procedure indication is not widely accepted because its technical difficulty and risk complications [1] [2]. In order to minimize damage deeper tissues, we have developed a novel electrosurgical knife, “B-Knife” (BSBK21S35/45; Zeon Medical Inc., Tokyo, Japan), that uses bipolar current system.
Abstract Exostoses like‐3 ( EXTL3 ) is a putative tumour suppressor gene but its involvement in colorectal cancer (CRC) unclear. We have investigated the role of methylation promoter as mechanism for regulation and tested hypothesis that loss expression associated with mucinous differentiation alteration glycoprotein CRC cells. The status was analysed by methylation‐specific PCR following bisulphite modification cell lines microdissected primary tissues their corresponding adjacent normal...
The purpose of this study was to assess the prognostic influence beta-catenin expression by immunohistochemistry in patients with cervical adenocarcinomas. group comprised 51 who underwent total hysterectomy for cancer. median follow-up 39 months (range 1-138 months). expressed strongly on membranes normal epithelial and glandular cells. Uniform membranous staining localized intercellular borders observed 35% tumors, whereas 65% tumors demonstrated an abnormal pattern reduced or aberrant...
Necl-5 is an immunoglobulin-like molecule that was originally identified as a poliovirus receptor. Although expression often up-regulated in cancer cells, its pathophysiological significance the development of remains unclear. We investigated roles colitis-associated neoplasia. Necl-5-deficient mice were generated and treated with dimethylhydrazine (DMH) and/or dextran sodium sulphate (DSS) to induce colitis associated neoplasias. Colon tissues examined for histology, Ki-67 by...
This study aimed to understand the optimal characteristics of friction dampers considering sway-rocking (SR) motion in vibration control structures during earthquakes. The nonlinear seismic response was numerically obtained using a six-story reinforced-concrete building model with damper and SR springs damping elements. results indicate that case shows less sensitive change increased sliding force higher force, compared fixed-base (FB) case. Moreover, reversal phenomenon may occur curve for...