A5029766112- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Dysphagia Assessment and Management
- IL-33, ST2, and ILC Pathways
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Eosinophilic Disorders and Syndromes
- Inflammatory mediators and NSAID effects
- Gastrointestinal disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Appendicitis Diagnosis and Management
- Inflammatory Bowel Disease
- Gut microbiota and health
- Barrier Structure and Function Studies
Hyogo University
2010-2023
Hyogo Medical University
2011-2021
Case Western Reserve University
2017-2020
MetroHealth Medical Center
2017-2020
Jikei University School of Medicine
2009
Magnifying endoscopy combined with narrow-band imaging (ME-NBI) has been used for differential diagnosis of various focal lesions. The aim our study was to evaluate ME-NBI criteria cancer in superficial depressed gastric lesions comparison conventional white light (WLE).ME-NBI and WLE images 100 depressions (55 cancers, 45 benign depressions) were independently evaluated by 11 endoscopists blinded the each case. presence or absence predefined findings relating microvasculature fine mucosal...
Gastroesophageal reflux disease (GERD) is a common globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered of middle-aged older people. Since risk factors for affect growing number adult population, concerns have raised that increasingly younger people may develop GERD. We aim to determine if proportion patients increased among population.The incidence as well several variables were evaluated during an 11-year...
Interleukin-22 (IL-22) has been recently highlighted owing to its biological significance in the modulation of tissue responses during inflammation. However, role IL-22 carcinogenesis remained unclear. Here, we investigated pathophysiological expression gastric cancer tissues and examined mechanism by which promotes cell invasion. Human specimens were analysed immunohistochemistry for receptor 1 (IL-22R1). The effects IL-22-induced STAT3 ERK signalling on invasive ability cells using a...
Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) investigate defecation habits and (2) examine the prevalence using Japanese Society Internal Medicine (JSIM) Rome III criteria an online survey.An questionnaire composed items on frequency, interval, form defecation, management, self-recognition (reference standard constipation) was created. A total 5155 valid responses received. In...
Haruki Asano, Toshihiko Tomita, Kumiko Nakamura, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Kazuhito Fukushima, Shozo Hirota, Jiro Watari, and Hiroto Miwa. J Neurogastroenterol Motil 2017;23:392-9. https://doi.org/10.5056/jnm16173
Abstract Background and Aims: Proton pump inhibitors (PPIs) are generally used to prevent delayed bleeding after endoscopic submucosal dissection (ESD) heal the artificial ulcers. However, it remains controversial whether PPIs or histamine‐2 receptor antagonists (H 2 RAs) more effective in preventing ESD. We prospectively compared effects of omeprazole famotidine promoting ulcer healing Methods: A total 158 patients (155 early gastric cancers three adenomas) were randomly assigned PPI group...
Whether Helicobacter pylori eradication actually suppresses the development of metachronous gastric cancer (MGC) after endoscopic resection (ER) remains controversial. The aims this study were to clarify (1) molecular markers related carcinogenesis in intestinal metaplasia (IM) by a cross-sectional study, and (2) changes those an open-label, randomised controlled trial (RCT) H. treatment. First, we evaluated microsatellite instability (MSI), methylation status at hMLH1, CDKN2A APC genes,...
The risk of gastric cancer (GC) remains in precancerous conditions, including atrophic mucosa and intestinal (IM), even after H. pylori treatment. To define the molecular changes following eradication, alterations with without GC were evaluated a long-term follow-up study. A total 232 biopsy specimens from 78 consecutive patients, gastritis patients ≥3 y successful eradication (AG group), who developed early (≥3 y) (GC pylori-positive (Hp analyzed. was associated significant reductions...
Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects MgO Japanese CC patients.We conducted randomized, double-blind placebo-controlled study. Thirty-four female patients with mild moderate were randomly assigned either placebo (n = 17) or group 0.5 g × 3/day 28 days. Primary endpoint was overall improvement over 4-week period. Secondary endpoints changes from baseline...
Abstract Background Studies have demonstrated a bi‐directional relationship between sleep deficiency and gastroesophageal reflux disease (GERD). However, there is limited data on how affects esophageal acid exposure. We aimed to compare the effect of exposure healthy controls versus GERD patients. Methods Eleven patients from each 2 groups were randomized undergo pH‐testing after consecutive days 7‐8 hours per night (normal sleep) or 4 (deficient sleep). All subjects then crossed over other...
Gastroesophageal reflux disease (GERD) is a prevalent, chronic medical condition that affects 13% of the adult population globally at least once week. Sleep disturbances are frequently encountered in up to 25% GERD patients, likely due nocturnal gastroesophageal (GER). With advance diagnostic techniques allowing for an improved understanding involved physiological mechanisms reflux, there growing evidence bidirectional relationship between and sleep disturbances. Furthermore, GER associated...
To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) without cytology and mucosal cutting (MCB) in histological diagnosis gastric submucosal tumor (SMT).We prospectively compared diagnostic yield, feasibility, safety EUS-FNAB those MCB based on dissection. The cases 20 consecutive patients with SMT ≥ 1 cm diameter. who underwent both were investigated.The diagnoses gastrointestinal stromal tumors (n = 7), leiomyoma 6), schwannoma 2),...
Background/Aims: Bile acids have recently been associated with the pathogenesis of irritable bowel syndrome (IBS). We therefore evaluated expression bile acid receptors in intestinal mucosa IBS patients as well effects on small epithelial cells. Methods: Intestinal biopsy specimens were obtained from 15 and healthy controls. The stimulation trans-epithelial electrical resistance (TEER) permeability differentiated Caco-2 cells measured. Proinflammatory cytokines measured by enzyme-linked...
Few studies are available that have investigated the risk factors for overlapping irritable bowel syndrome (IBS)-like symptoms in patients with inactive inflammatory disease (IBD). The present study has 3 objectives: (1) to assess prevalence of IBS-like Japanese IBD using Rome III criteria, (2) examine relationship health related quality life (HR-QOL), and (3) investigate associations developing IBD.IBS-like were evaluated questionnaire functional gastrointestinal disorders. HR-QOL hospital...
Background Esophageal linear furrows, corrugated rings, and/or white exudates are often seen in patients with eosinophilic esophagitis ( EoE ); however, whether these specific to remains unclear. Endoscopic surveillance of features was conducted determine represent esophageal eosinophilia, which is essential for the diagnosis . Patients and Methods Two thousand seven hundred sixty‐three were enrolled consecutively. Target biopsy carried out when above seen. Histological eosinophilia defined...
Scintigraphy is a useful noninvasive technique for assessment of gastric motility, especially emptying, but there little knowledge use the to assess accommodation. Therefore, clarify usefulness scintigraphy as assessing accommodation, we compared with barostat, gold standard modality.Twenty healthy volunteers (14 men, six women; mean age, 28.5 ± 5.4 years) were enrolled in study. The ingested radiolabeled ((99m) Tc) test meal and scintigraphic images recorded. Radioactivity upper third whole...
Intestinal epithelial barrier function is impaired in irritable bowel syndrome patients. Claudins are highly expressed cells with tight junctions and involved the intestinal function. The expression pattern of junction proteins diarrhea-predominant have not been fully elucidated. We therefore recruited 17 patients 20 healthy controls. junction-related was examined ileal, cecal, rectal mucosa using real-time PCR immunofluorescence. Claudin-2 high ileum same cecum control Similarly, clauidn-1,...