A5078407139- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Lung Cancer Research Studies
- Pancreatitis Pathology and Treatment
- Cancer and Skin Lesions
- Pediatric Hepatobiliary Diseases and Treatments
- Cytokine Signaling Pathways and Interactions
- Ear and Head Tumors
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
Saitama Prefectural Kumagaya Girls High School
2022-2025
University of Toyama
2014-2023
Toyama City Hospital
2022
Niigata University
2021
Tokushima University
2021
Toyama University Hospital
2020
Hiroshima University
2015
Hiroshima University Hospital
2015
Dana-Farber Cancer Institute
2015
Montreal Heart Institute
2015
Abstract Adipose tissue resident macrophages have important roles in the maintenance of homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like adipose systemic glucose inhibiting adipocyte progenitor proliferation via CD206/TGFβ signaling pathway. We CD206 + cells are primarily macrophages, ablation improves sensitivity, which was associated with an increased number smaller adipocytes. Mice genetically...
Skeletal muscle is mainly responsible for insulin-stimulated glucose disposal. Dysfunction in skeletal metabolism especially during obesity contributes to the insulin resistance. Astaxanthin (AX), a natural antioxidant, has been shown ameliorate hepatic resistance obese mice. However, its effects are poorly understood. The current study aimed investigate molecular target of AX ameliorating resistance.We fed 6-week-old male C57BL/6J mice with normal chow (NC) or NC supplemented (NC+AX) and...
Adipose tissue hypoxia is an important feature of pathological adipose expansion. Hypoxia-inducible factor-1α (HIF-1α) in adipocytes reportedly induces oxidative stress and fibrosis, rather than neoangiogenesis via vascular endothelial growth factor (VEGF)-A. We previously reported that macrophages crown-like structures (CLSs) are both hypoxic inflammatory. In the current study, we examined how macrophage HIF-1α involved high-fat diet (HFD)–induced inflammation, neovascularization, hypoxia,...
Although stromal cell-derived factor (SDF)-1α and its receptor CXCR4 are experimentally suggested to be involved in tumorigenicity, the clinicopathological significance of their expression human disease is not fully understood. We examined SDF-1α colorectal cancers (CRCs) related lymph nodes (LNs), investigated relationship features. Specimens 60 primary CRCs 27 LNs were immunohistochemically for only positivity but also immunostaining patterns CXCR4. The relationships between features or...
Interleukin-22 (IL-22) has been recently highlighted owing to its biological significance in the modulation of tissue responses during inflammation. However, role IL-22 carcinogenesis remained unclear. Here, we investigated pathophysiological expression gastric cancer tissues and examined mechanism by which promotes cell invasion. Human specimens were analysed immunohistochemistry for receptor 1 (IL-22R1). The effects IL-22-induced STAT3 ERK signalling on invasive ability cells using a...
Abstract Macrophages (MΦs) are involved in folliculogenesis and ovulation. However, it is unknown which type of MΦ, M1 or M2, plays a more essential role the ovary. CD206 CD11c diphtheria toxin receptor transgenic (DTR) mice, enable depletion CD206+ M2 MΦs CD11c+ MΦ Dendritic cells (DCs), respectively, were used. Oocytes used for vitro fertilization embryo transfer. In fertilized embryos derived from depleted oocytes transferred to pseudo pregnant wild mice. DTR mice also investigate cells,...
Abstract Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate paracrine secretion FAPs during recovery process remains elusive. Herein, we systemically investigated communication between CD206 + M2-like using a transgenic mouse model. Depletion or deletion macrophages-specific TGF-β1 gene induces myogenesis regeneration. We show that depletion activates activated secrete follistatin,...
<i>Objectives:</i> Although it has been reported that epidermal growth factor receptor (EGFR) is able to translocate from the plasma membrane nucleus, pathophysiological role of this translocation in tumorigenicity still unclear. In present study, elucidate significance EGFR translocation, we investigated expression not only conventional but also its phosphorylated form (pEGFR), focusing on cellular localization esophageal cancer tissues. <i>Methods:</i> Fifty-two...
Interleukin (IL)-22 is a recently identified cytokine that suggested to play pivotal roles in various inflammatory diseases. Although the IL-22 receptor 1 (IL-22R1) restrictively expressed epithelial cells colon, role of colonic diseases still remains unclear. In this study microarray analyses revealed deleted malignant brain tumors (DMBT1) novel upregulated gene IL-22-stimulated colon cancer cells. Therefore, we investigated involvement DMBT1 and ulcerative colitis (UC) tissues examined...
Abstract Background Serrated polyps belong to a heterogeneous group of lesions that are generally characterized morphologically. This type lesion is thought be the precursor sporadic carcinomas with microsatellite instability, and probably also for CpG island-methylated microsatellite-stable carcinomas. For practical purposes, according 2010 WHO classification, diagnostic criteria sessile serrated adenomas/polyps (SSA/Ps) was established by research project “Potential Cancerization...
<b>Background:</b> Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these morphological and genetic characteristics different from UC neoplasia. <b>Aims:</b> To establish a new model p53 deficient mice by treatment with dextran sulphate sodium (DSS). <b>Methods:</b> DSS was induced homozygous (p53<sup>−/−</sup>-DSS), heterozygous (p53<sup>+/−</sup>-DSS) wild-type (p53<sup>+/+</sup>-DSS) 4% DSS. Numbers of...
Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of the autonomic nervous system. In instances, paragangliomas present around and involve pancreas, thereby mimicking one more common primary pancreatic lesions. These considerable diagnostic difficulty not only for clinician radiologist but also pathologist. We have collected a series 9 peripancreatic clinically simulating lesion. The were diagnosed 4 men 5 women with an age range 37 to 78 years (mean,...
Pure non-gestational choriocarcinoma is a primary germ cell neoplasm that has been defined as tumor without other elements. The current study presents an extremely rare case of pure in postmenarcheal young female and describes details the tumor, including clinicopathological findings. patient was 10-year-old who underwent salpingo-oophorectomy. Histologically, extensive hemorrhagic composed additional components. cells were immunohistochemically positive for epithelial markers, cytokeratins...
Expansion of adipose tissue during obesity through the recruitment newly generated adipocytes (hyperplasia) is metabolically healthy, whereas that enlargement pre-existing (hypertrophy) leads to metabolic complications. Accumulating evidence from genetic fate mapping studies suggests in animal models receiving a high-fat diet (HFD), only adipocyte progenitors (APs) gonadal white (gWAT) have proliferative potential. However, potential and differentiating capacity APs inguinal WAT (iWAT) male...
We isolated a metastasizing human esophageal squamous cell carcinoma (SCC) line, T.Tn‐AT1, from parental non‐metastasizing T.Tn, by in vitro selection and use of nude mouse orthotopic inoculation model. Then, we compared the expression profiles 9206 genes T.Tn‐AT1 T.Tn cDNA microarray analysis. The gene were very similar, only 34 showed more than 3‐fold differential expression. Among genes, 29 down‐regulated 5 up‐regulated cells. Subsequently, confirmed levels 14 cells means reverse...
Purpose. Nonalcoholic fatty liver disease (NAFLD) is a progressive and intractable associated with metabolic syndrome. Red yeast rice (RYR) contains monacolin K, potent inhibitor of HMG-CoA reductase, its consumption decreases cholesterol triglyceride levels. We examined the efficacy RYR constituents using novel syndrome-NAFLD mouse model (MSG mice). Methods. Two types grown under different culture conditions were used. 1P-DU contained only 0.002 g/100 g whereas 3P-D1 0.131 g. MSG mice...
Objective To investigate the reactivity of monoclonal anti–citrullinated protein antibody (ACPA) obtained from peripheral blood B cells rheumatoid arthritis (RA) patients with human autoantigens as well environmental proteins by determining essential epitope for ACPA. Methods A ACPA (cyclic citrullinated peptide 1 [CCP‐Ab1]) was screening lymphocytes 31 RA using a novel antibody–secreting cell (ASC) system, immunospot‐array assay on chip. The CCP‐Ab1 determined mapping. Then, human,...