A5063350161- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Protease and Inhibitor Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Diabetes Treatment and Management
- Blood Coagulation and Thrombosis Mechanisms
- Eosinophilic Disorders and Syndromes
- Bone health and treatments
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Diabetes Management and Research
- Blood properties and coagulation
- Urticaria and Related Conditions
- Mycobacterium research and diagnosis
- Diabetes and associated disorders
- Tuberculosis Research and Epidemiology
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Pancreatic function and diabetes
- Atrial Fibrillation Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Jichi Medical University
2013-2024
Kumamoto Medical Center
2018-2024
Kochi Gakuen College
2024
Kōchi University
2024
Osaka University
1988-2023
University of Oxford
2023
Kameda Medical Center
2020
Tochigi Medical Center
2019
Jichi Medical University Hospital
2007-2018
Nara Institute of Science and Technology
2018
Since activated factor X (FXa) is a coagulant enzyme that generates thrombin and participates in both intrinsic extrinsic coagulation pathways, inhibition of FXa may be more effective than inactivation for interrupting blood coagulation. To assess the possible effectiveness as an anticoagulant, we designed synthesized 3-(amidinoaryl)-2-[4-[(3S)-3-pyrrolidinyloxy]phenyl]propanoi c acid derivatives low molecular weight, nonpeptidic, orally active inhibitors. These exhibited potent highly...
To determine levels of interleukin 33 (IL-33) in serum and synovial fluid (SF) their clinical associations patients with rheumatoid arthritis (RA). evaluate the ability activated peripheral blood mononuclear cells (PBMC) fibroblast-like synoviocytes (FLS) from RA to release IL-33.Sera were obtained 59 RA, 10 infectious diseases, 42 healthy volunteers. SF samples 15 13 osteoarthritis. IL-33 measured using a sandwich ELISA after removal factor protein A-Sepharose beads. FLS stimulated IL-1beta...
<h3>Objectives</h3> To evaluate efficacy and safety of combination therapy using certolizumab pegol (CZP) methotrexate (MTX) as first-line treatment for MTX-naive, early rheumatoid arthritis (RA) with poor prognostic factors, compared MTX alone. <h3>Methods</h3> RA patients ≤12 months persistent disease, high anti-cyclic citrullinated peptide, either factor positive and/or presence bone erosions were enrolled in this multicentre, double-blind, randomised placebo (PBO)-controlled study....
Summary DX-9065a is an orally active newly synthesized and specific inhibitor for factor Xa. We have examined the property of in vitro ex vivo. prolonged human plasma recalcification time, APTT PT. Its doubling concentrations clotting times each coagulation assay were 0.49, 0.97 0.52 μM, respectively. Kinetic study revealed that inhibited competitively Xa (Ki value: 41 μM). Ki values (pM) other serine proteases as follows; thrombin >2000, trypsin 0.62, chymotrypsin plasmin 23, t-PA 21,...
Objective To examine the incidence of hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis (RA) receiving biological disease-modifying antirheumatic drugs (DMARDs). Methods We retrospectively reviewed RA treated DMARDs at our institution from July 2010 to December 2012. Patients antibodies for core antigen and/or surface were regarded as having prior HBV infection. Clinical data on these patients, including HBV-DNA levels, retrieved medical records. Results During study...
Summary We evaluated the antithrombotic effects of DX-9065a, a specific factor Xa inhibitor, using tissue thromboplastin-induced DIC (TP-DIC) and arterio-venous shunt (AV shunt) in rats. Intravenous TP injection reduced platelet counts fibrinogen concentrations blood. In TP-DIC model, an intravenous dose DX-9065a 0.23 mg/kg 1 min before suppressed consumption platelets to 57% 66%, respectively, production FDP almost completely. AV inhibited thrombus formation 51% on administration 60% when...
A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide. Because all bacteriology findings were negative, steroid pulse-therapy was initiated promptly due to rapidity chest X-ray progression deterioration arterial blood oxygen pressure. Although induced by methotrexate, interstitial pneumonia not detected clinically before leflunomide administration. He finally died...
We previously evaluated Wilms' tumor gene 1 (WT1) peptide vaccination in a large number of patients with leukemia or solid tumors and have reported that HLA-A*24:02 restricted, 9-mer WT1-235 (CYTWNQMNL) vaccine induces cellular immune responses elicits WT1-235-specific cytotoxic T lymphocytes (CTLs). However, whether this humoral to produce WT1 antibody remains unknown. Thus, we measured IgG levels against the (WT1-235 antibody) glioblastoma multiforme (GBM) receiving vaccine. The antibody,...
Abstract Aims The ongoing FAMILIAR trial aims to provide evidence for clinical decision‐making and offer a novel treatment paradigm in type 2 diabetes mellitus (T2DM) management. interim findings of through Week 24 are reported. Materials Methods is multicentre, randomised, double‐blind study comparing the efficacy safety imeglimin versus placebo adult Japanese patients with T2DM inadequate glycaemic control despite dipeptidyl peptidase‐4 (DPP‐4) inhibitor monotherapy, plus diet/exercise...
Development of new methods for accelerating orthodontic tooth movement has been strongly desired shortening the treatment period. The rate is dependent on bone resorption occurring in compressed periodontium direction force applied to tooth. In present study, we examined effects continuous infusion parathyroid hormone (PTH) movement. Male rats weighing 350-400 g were treated with subcutaneous vehicle or hPTH(1-84) at 1-10 micrograms/100 body weight/day. When upper right first molar (M1) was...
Abstract A diarylethene having 2-cyanopyrrole rings turned blue upon UV irradiation in ethyl acetate. The colored form was unstable and returned to the colorless open-ring with a half-life time of 37 s at room temperature. activation energy thermal fading obtained be 32.5 kJ / mol, which is less than half that spironaphthoxazine.
Males from the BXSB murine strain (H-2b) spontaneously develop an autoimmune syndrome with features of systemic lupus erythematosus (SLE), which results in part action a mutant gene (Yaa) located on Y chromosome. Like other H-2b mice, does not express class II major histocompatibility complex antigen, I-E. Here we report that expression I-E (E alpha dE beta b) males bearing E d transgene prevents hypergammaglobulinemia, autoantibody production, and subsequent glomerulonephritis. These...
The effects of PTH and calcitonin (CT) on the expression mineralization-related phenotypes by chondrocytes were examined. In cultures pelleted growth-plate chondrocytes. caused 60-90% decreases in alkaline phosphatase activity, incorporation 45Ca into insoluble material, calcium content during post-mitotic stage. These dose-dependent reversible. contrast, CT increased 1.4- to 1.8-fold. observations suggest that directly inhibits chondrocytes, has opposite effects.
Endothelial cell (EC) activation underlies many vascular diseases, including pulmonary arterial hypertension (PAH). Several members of the E-twenty six (ETS) family transcription factors are important regulators gene network governing endothelial homeostasis, and their aberrant expression is associated with pathological angiogenesis. The goal this study was to determine whether deficiencies ETS member, Friend leukemia integration 1 factor (FLI1), its closest homolog, ETS-related (ERG), PAH....
Sodium-glucose cotransporter 2 inhibitor tofogliflozin is a new type of antidiabetic drug for individuals with diabetes mellitus (T2DM). The aim this study was to examine in which and/or under conditions could exert more beneficial effects on body composition glycemic control Japanese T2DM. We retrospectively evaluated the T2DM who newly started taking tofogliflozin. After treatment, weight significantly reduced and HbA1c levels were decreased. Body fat mass, skeletal muscle index, marker...
ABSTRACT Objectives To define groups and characterize differences in the prognosis of patients with adult-onset Still’s disease (AOSD). Methods We performed a retrospective cohort study. Patients AOSD were grouped using hierarchical unsupervised cluster analysis according to age, sex, clinical features, laboratory data. The primary endpoints overall survival drug-free remission rate. Results A total 153 placed into four clusters. Those Cluster 1 had young onset, tended be female, fewer...