A5056879575- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Metastasis and carcinoma case studies
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Barrier Structure and Function Studies
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Pathogenesis and Treatment of Hiccups
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Nuclear Engineering Thermal-Hydraulics
- Hereditary Neurological Disorders
- Potassium and Related Disorders
- Lung Cancer Research Studies
Hyogo University
2010-2023
Hyogo Medical University
2012-2022
University of Technology Sydney
2015
Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) investigate defecation habits and (2) examine the prevalence using Japanese Society Internal Medicine (JSIM) Rome III criteria an online survey.An questionnaire composed items on frequency, interval, form defecation, management, self-recognition (reference standard constipation) was created. A total 5155 valid responses received. In...
Background Claudins are known as tight junction proteins, and their expression pattern in gastric cancer is still controversial. The relationship between the patterns of proteins tumor proliferation early far from clear. Aims To investigate claudin-18 Ki-67 at invasive front surrounding normal mucosa to biological function invasion cells. Methods Seventy-five lesions removed via endoscopic mucosal resection or submucosal were evaluated. All diagnosed differentiated adenocarcinoma using...
Haruki Asano, Toshihiko Tomita, Kumiko Nakamura, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Tadayuki Oshima, Hirokazu Fukui, Kazuhito Fukushima, Shozo Hirota, Jiro Watari, and Hiroto Miwa. J Neurogastroenterol Motil 2017;23:392-9. https://doi.org/10.5056/jnm16173
Aliment Pharmacol Ther 2012; 35: 175–182 Summary Background The mechanisms of the development symptoms in functional dyspepsia (FD) patients have not been fully elucidated. We previously reported that acid directly infused into stomach causes dyspeptic asymptomatic healthy controls (HCs); however, response to infusion FD was determined. Aim To investigate severity induced by direct subjects and HCs. Methods This a multi‐centre, cross‐over, randomised, double‐blind study 23 32 defined using...
Abstract Background and Aims: Proton pump inhibitors (PPIs) are generally used to prevent delayed bleeding after endoscopic submucosal dissection (ESD) heal the artificial ulcers. However, it remains controversial whether PPIs or histamine‐2 receptor antagonists (H 2 RAs) more effective in preventing ESD. We prospectively compared effects of omeprazole famotidine promoting ulcer healing Methods: A total 158 patients (155 early gastric cancers three adenomas) were randomly assigned PPI group...
Background/Aims: Bile acids have recently been associated with the pathogenesis of irritable bowel syndrome (IBS). We therefore evaluated expression bile acid receptors in intestinal mucosa IBS patients as well effects on small epithelial cells. Methods: Intestinal biopsy specimens were obtained from 15 and healthy controls. The stimulation trans-epithelial electrical resistance (TEER) permeability differentiated Caco-2 cells measured. Proinflammatory cytokines measured by enzyme-linked...
Background Esophageal linear furrows, corrugated rings, and/or white exudates are often seen in patients with eosinophilic esophagitis ( EoE ); however, whether these specific to remains unclear. Endoscopic surveillance of features was conducted determine represent esophageal eosinophilia, which is essential for the diagnosis . Patients and Methods Two thousand seven hundred sixty‐three were enrolled consecutively. Target biopsy carried out when above seen. Histological eosinophilia defined...
Scintigraphy is a useful noninvasive technique for assessment of gastric motility, especially emptying, but there little knowledge use the to assess accommodation. Therefore, clarify usefulness scintigraphy as assessing accommodation, we compared with barostat, gold standard modality.Twenty healthy volunteers (14 men, six women; mean age, 28.5 ± 5.4 years) were enrolled in study. The ingested radiolabeled ((99m) Tc) test meal and scintigraphic images recorded. Radioactivity upper third whole...
To clarify the diagnostic efficacy and limitations of endoscopic ultrasonography (EUS) characteristics early gastric cancers (EGCs) that are indications for EUS-based assessment cancer invasion depth.We retrospectively investigated cases 153 EGC patients who underwent conventional endoscopy (CE) EUS (20 MHz) before treatment.We found 13.7% were "inconclusive" with low-quality images, including all nine protruded (0-I)-type EGCs. There was no significant difference in accuracy between CE EUS....
The association between obesity and Barrett's esophagus (BE) in the Japanese population remains unclear. prevalence of BE its associated risk factors was examined. A cross-sectional study 1581 consecutive individuals who underwent upper gastrointestinal endoscopy conducted. endoscopically suspected (ESBE) evaluated. Obesity evaluated by body mass index (BMI, ≥ 25 kg/m2) waist circumference (WC) (males, 85 cm; females, 90 cm). Because endoscopic diagnosis ultra-short ESBE (<1 cm extent) is...
A 41-year-old woman was referred with epigastric discomfort. She had a 20-year history of SLE. Esophagogastroduodenoscopy (EGD) examination showed severe atrophic gastritis in the stomach and protruding lesion detected. Histological carcinoid tumor cytoplasmic staining chromogranin-A. Using an endoscopic submucosal dissection (ESD) technique, en bloc resection performed. No recurrence has been found for 3 years after treatment. Type I gastric can occur at earlier age AIG autoimmune diseases...
Background Interleukin-33 (IL-33) is a tissue-derived cytokine that constitutively expressed in epithelial cells of tissues exposed to the environment and plays role sensing damage caused by inflammatory diseases. IL-33 acts as both traditional chromatin-associated nuclear factor innate adaptive immunity. We recently showed esophageal mucosa upregulated reflux esophagitis. However, expression patients with heartburn without mucosal injury its relationship intercellular space (ICS) have never...
Diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms are distressing for patients with quiescent Crohn's disease (qCD) and worsen their quality of life. In the present study, we assessed effect probiotic Bifidobacterium bifidum G9-1 (BBG9-1) on intestinal environment clinical features in qCD. Eleven qCD, who met Rome III diagnostic criteria IBS-D, received BBG9-1 (24 mg) orally three times daily 4 weeks. Indices (fecal calprotectin level gut microbiome) (CD/IBS-related...
There have been no reports of Cronkhite–Canada syndrome (CCS) associated gastric cancer resected with endoscopy because it is very difficult to identify small cancers that are candidates for endoscopic resection. We report a case CCS treated submucosal dissection, and we evaluate the molecular pathological analysis malignant transformation in patients CCS. A 74-year-old man had an advanced rectal gastrointestinal polyposis after presenting hypoproteinemia, partial hair loss atrophic nails as...
Early detection of gastric cancer is important. However, rapid growth cancers that cannot be resected endoscopically occurs even with periodic check-ups. Accordingly, we assessed factors associated the speed by examining historical endoscopic images. A total 1996 cases were screened, and characteristics lesions slow assessed. 114 from patients included in assessment. Sixty slow-growing fifty-four rapidly growing compared. Female sex incidence lower part stomach significantly less frequent...
The subtypes of functional dyspepsia (FD) differ depending on whether the Rome III criteria or IV are used. We investigated ability to diagnose FD patients using and criteria. were evaluated questionnaire. Gastrointestinal Symptom Rating Score, health-related quality life (HR-QOL; SF-8), psychological scores (HADS, STAI) evaluated. questionnaire was collected from a total 205 patients, 54.1% patients. ratio under 19% for epigastric pain syndrome (EPS), 38% postprandial distress (PDS), 43% an...
Background: The frequency of delayed bleeding after colorectal polypectomy has been reported as 0.6–2.8%. With the increasing performance under continuous use antithrombotic agents, care is required regarding post-polypectomy (DPPB). Better instruction to educate endoscopists therefore needed. We aimed evaluate effect and factors associated with endoscopic polyp resection. Methods: This single-center, retrospective study was performed assess in checking complete hemostasis risk for onset...