A5077314116- Sphingolipid Metabolism and Signaling
- ATP Synthase and ATPases Research
- HER2/EGFR in Cancer Research
- Endoplasmic Reticulum Stress and Disease
- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Testicular diseases and treatments
- Genetic factors in colorectal cancer
- Paraoxonase enzyme and polymorphisms
- Colorectal Cancer Treatments and Studies
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Cancer Treatment and Pharmacology
- Protein Tyrosine Phosphatases
- Intraperitoneal and Appendiceal Malignancies
- Drug Transport and Resistance Mechanisms
- Appendicitis Diagnosis and Management
- Spectroscopy Techniques in Biomedical and Chemical Research
Metaxa Hospital
2011-2024
Helios Klinikum Krefeld
2022
University of Massachusetts Amherst
2001-2009
St Savas Hospital
2007
Aristotle University of Thessaloniki
2007
Onassis Cardiac Surgery Center
2006
National and Kapodistrian University of Athens
2006
National Hellenic Research Foundation
1993-1994
Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients colorectal cancer were invited to provide that data in a schematized format for inclusion collaborative database called RASCAL (The in-colorectal-cancer group). Our results from 2721 such have been presented previously first time any common cancer, showed conclusively different gene mutations impacts on outcome, even when occur at same site genome. To explore effect Ki-ras stages...
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Background Fibrosis, the replacement of functional tissue with excessive fibrous tissue, can occur in all main tissues and organ systems, resulting various pathological disorders. Idiopathic Pulmonary Fibrosis is a prototype fibrotic disease involving abnormal wound healing response to multiple sites ongoing alveolar epithelial injury. Methodology/Principal Findings To decipher role TNF TNF-mediated inflammation development fibrosis, we have utilized bleomycin-induced animal model series...
Abstract Background Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other factors, notably ASF/SF2. The altered expression pattern hnRNP A2/B1 and/or variant B1 alone human lung cancer and their potential to serve as molecular markers for early diagnosis remain issues intense investigation. main objective present study was use paired tumour/non-tumour...
Pathogenesis and progression of lung cancer are governed by complex interactions between the environment host genetic susceptibility, which is further modulated epigenetic changes. Autotaxin (ATX, ENPP2) a secreted glycoprotein that catalyzes extracellular production lysophosphatidic acid (LPA), growth-factor-like phospholipid regulated phosphatases (PLPP). LPA's pleiotropic effects in almost all cell types mediated through at least six G-protein coupled LPA receptors (LPAR) exhibit...
HER2 and TOP2A parameters (gene status, mRNA protein expression) have individually been associated with the outcome of patients treated anthracyclines. The aim this study was to comprehensively evaluate prognostic/predictive significance above in early, high-risk breast cancer epirubicin-based, dose-dense sequential adjuvant chemotherapy. In a series 352 carcinoma tissues from that had post-operatively epirubicin-CMF or without paclitaxel, we assessed gene status (chromogenic situ...
Background-Aim To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, E1, p21, p27 and p53 in context various breast cancer subtypes. Methods Cyclin p53, p21 were evaluated with immunohistochemistry 1077 formalin-fixed paraffin-embedded tissues from patients who had been treated within clinical trials. Jaccard distances computed for markers resulted matrix was used conducting unsupervised hierarchical clustering, order to identify distinct groups correlating...
Primary osteogenic sarcomas of the breast are extremely rare neoplasms. The histologic and cytologic features comparable to those their soft tissue skeletal counterparts. To assess utility fine needle aspiration (FNA) in preoperative identification sarcomas, we retrospectively reviewed FNA findings 3 cases diagnosed our hospital over 2 1/2 years.Three women, aged 48, 55 76 years, presented with a palpable lump few months' duration breasts. was indicative malignancy, mastectomy ipsilateral...
Histone H2AX undergoes phosphorylation as an answer to DNA double-strand breaks, which in turn are part of the oncogenic procedure. The detection gamma-H2AX can potentially serve a biomarker for transformation normal tissue premalignant and consequently malignant tissues. aim this study was evaluate clinical significance expression breast cancer. Gamma-H2AX tissues from 110 cancer patients analyzed by immunohistochemistry correlated with clinicopathological variables. Greater tumor size,...
Acheron, a Lupus antigen ortholog, was identified as novel death-associated transcript from the intersegmental muscles of moth Manduca sexta. Acheron is phylogenetically-conserved and represents new sub-family proteins. expressed predominantly in neurons muscle vertebrates, regulates several developmental events including myogenesis, neurogenesis possibly metastasis. Using bait, we performed yeast two-hybrid screen with mouse embryo cDNA library CASK-C, CASK/Lin-2 isoform, an binding...