A5008841797- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Erythropoietin and Anemia Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- Iron Metabolism and Disorders
- PARP inhibition in cancer therapy
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- Biosimilars and Bioanalytical Methods
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Statistical Methods in Clinical Trials
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Neutropenia and Cancer Infections
- Blood transfusion and management
Hellenic Cooperative Oncology Group
2018-2024
424 General Military Hospital
2008-2023
Theageneio General Hospital
2023
Euromedica
2011-2022
Kyanous Stavros Hospital
2011-2012
Aristotle University of Thessaloniki
2005
AHEPA University Hospital
2005
Several studies support an important role of angiogenesis in breast cancer growth and metastasis. The main objectives the study were to investigate immunohistochemical expression vascular endothelial factor (VEGF) family ligands (VEGF-A VEGF-C) receptors (VEGFR1, VEGFR2 VEGFR3) their associations with clinicopathological parameters, subtypes/subgroups patient outcome. Formalin-fixed paraffin-embedded tumor tissue samples collected from early-stage patients treated anthracycline-based...
Colon cancer is a public health problem worldwide. Adjuvant chemotherapy after surgical resection for stage III colon has been shown to improve both progression-free and overall survival, currently recommended as standard therapy. However, its value patients with II disease remains controversial. When this study was designed 5-fluorouracil (5FU) plus leucovorin (LV) adjuvant treatment cancer. Irinotecan (CPT-11) topoisomerase I inhibitor activity in metastatic disease. In multicenter phase...
Background-Aim To evaluate the prognostic role of elaborate molecular clusters encompassing cyclin D1, E1, p21, p27 and p53 in context various breast cancer subtypes. Methods Cyclin p53, p21 were evaluated with immunohistochemistry 1077 formalin-fixed paraffin-embedded tissues from patients who had been treated within clinical trials. Jaccard distances computed for markers resulted matrix was used conducting unsupervised hierarchical clustering, order to identify distinct groups correlating...
// George Fountzilas 1, 2, * , Eleni Giannoulatou 3, 4 Zoi Alexopoulou 5 Flora Zagouri 6 Timotheadou 7 Kyriaki Papadopoulou 1 Sotiris Lakis Mattheos Bobos Christos Poulios 8 Maria Sotiropoulou 9 Aggeliki Lyberopoulou Helen Gogas 10 Pentheroudakis 11 Dimitrios Pectasides 12 Angelos Koutras 13 Christodoulou 14 Papandreou 15 Epaminontas Samantas 16 Pavlos Papakostas 17 Paris Kosmidis 18 Bafaloukos 19 Charisios Karanikiotis 20 Meletios-Athanassios Dimopoulos Vassiliki Kotoula 8, Laboratory of...
The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such paclitaxel anthracyclines. TOP2A associated response to Limited information exists on relationship HER2/TOP2A status in presence centromere 17 (CEP17) gain outcome treated anthracycline-containing adjuvant chemotherapy. Formalin-fixed paraffin-embedded tumor tissue samples from 1031 high-risk operable cancer, enrolled two consecutive...
Dose-dense sequential chemotherapy including anthracyclines and taxanes has been established in the adjuvant setting of high-risk operable breast cancer. However, preferable taxane optimal schedule administration a dose-dense regimen have not defined yet. From July 2005 to November 2008, 1001 patients (990 eligible) were randomized receive, every 2 weeks, 3 cycles epirubicin 110 mg/m2 followed by paclitaxel 200 intensified CMF (Arm A; 333 patients), or CMF, as Arm A, weeks later 9 weekly...
The adrenal gland is one of the common sites metastasis from primary lung cancer. Adrenal metastases are usually unilateral however bilateral seen in 10% all cancer patients; these 2-3% occurs at initial presentation non-small cell Secondary tumors can disrupt structure and function adrenal. This lead to hemorrhage, which constitutes a life threatening hazard for patient.A 59-year-old male presented with persisting abdominal pain. His work-up revealed significant anemia, an invasive process...
Prevention of bone metastases is a major issue for breast cancer patients, as it would improve quality life in population where long survival anticipated.Early who had been treated with anthracycline-based chemotherapy within two randomized trials, were included the study. We evaluated, by quantitative reverse transcription-polymerase chain reaction, 819 formalin-fixed paraffin-embedded tumor tissue samples mRNA expression RANK, OPG, and RANKL, well their ratios, potential prognostic...
Dose-dense sequential (dds) chemotherapy has changed the clinical outcome of patients with early breast cancer (BC). To investigate impact dose intensity (DI) in adjuvant setting BC, this observational trial (HE 10/10) was conducted assessing long-term survival outcome, safety and toxicity a currently widely used chemotherapeutic regimen. In addition, prognostic significance tumor infiltrating lymphocytes (TILs) CD8
Abstract Background Tumor‐infiltrating lymphocytes (TILs) have been shown to be of prognostic value in several cancer types. In early breast cancer, TILs a utility, as well, especially HER2‐positive and triple‐negative cancer. presence is broadly associated with improved survival; however, there controversy regarding subpopulations. Patients methods Early‐stage patients treated anthracycline‐based chemotherapy within two randomized trials were included the study. We evaluated, by qRT‐PCR,...
The retinoblastoma (RB) gene is a tumor-suppressor that plays central role in regulating the cell cycle. Inactivation of this involved breast cancer.A total 827 patients with cancer treated taxane-based adjuvant chemotherapy were included study. Protein expression RB, phosphorylated RB (pRB), p16, cyclin D1 and p53 was evaluated by immunohistochemistry.Neither markers (RB pRB) reached statistical significance terms their association disease-free or overall survival. Nevertheless, when...
The CHOICE study was a prospective, multicentre, observational designed to assess the level of adherence in current clinical practice European product label and EORTC guidelines for treatment chemotherapy-induced anaemia with darbepoetin alfa (DA).Hb levels red blood cell (RBC) transfusion requirements were evaluated among 1900 patients solid tumours 11 countries. primary outcome measure proportion target Hb ≥10-≤12 g/dL after 9 weeks' DA treatment.The full analysis set (FAS) comprised 1887...
The CHOICE study was a prospective, multicentre, observational designed to assess levels of adherence in current clinical practice the European product label and EORTC guidelines for treatment chemotherapy-induced anaemia (CIA) with darbepoetin alfa (DA). Here we present data split by tumour types: breast, colorectal, ovarian lung.Haemoglobin (Hb) red blood cell transfusion requirements were evaluated among patients solid tumours 11 countries. primary outcome measure proportion target Hb...
Objective:To evaluate adherence to European Organisation for Research and Treatment of Cancer (EORTC) Summary Product Characteristic (SmPC) guidance on recommended haemoglobin (Hb) values in routine clinical practice use darbepoetin alfa (DA) cancer patients internationally.Methods:This multicentre, prospective, observational study assessed DA 11 countries. This interim analysis (IA) included ∼1300 breast, colorectal, ovarian or lung receiving during any chemotherapy cycle. Hb level red...
Tumor-infiltrating lymphocytes (TILs) contribute to breast cancer (BC) prognosis. We investigated the prognostic impact of CD8+ TILs in patients with early treated adjuvant chemotherapy a large observational clinical trial. Along 10 year follow-up, considering efficacy and safety, we report results translational part our study. examined patients’ tumors for total (t), stromal (s), intratumoral (i) CD8 lymphocyte density (counts/mm2) on tissue-microarray cores. The counts DFS OS, its...