A5019192290- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Ear and Head Tumors
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cancer and Skin Lesions
- Urinary and Genital Oncology Studies
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Bacterial Infections and Vaccines
- Tuberous Sclerosis Complex Research
- Omental and Epiploic Conditions
- Cancer-related molecular mechanisms research
- Infectious Diseases and Mycology
- Ubiquitin and proteasome pathways
- Chromatin Remodeling and Cancer
- Cancer Cells and Metastasis
Aristotle University of Thessaloniki
2016-2025
Moffitt Cancer Center
2024
Mayo Clinic in Arizona
2018-2024
Mayo Clinic
2018-2022
Kameda Medical Center
2022
Emory University Hospital
2021
WinnMed
2019-2020
Mayo Clinic in Florida
2020
AHEPA University Hospital
2018
General Hospital of Athens G. Genimatas
2017-2018
Programmed death-ligand 1 (PD-L1; also known as CD274 or B7-H1) expression represents a mechanism of immune escape for cancer. Our purpose was to characterize tumor PD-L1 and associated T-cell infiltration in primary laryngeal squamous cell carcinomas (SCC).A well-annotated cohort 260 operable SCCs [formalin-fixed paraffin-embedded (FFPE) specimens] morphologically characterized stromal tumor-infiltrating lymphocytes (TIL), on hematoxylin/eosin-stained whole sections mRNA by qRT-PCR FFPE...
Clinical immunotherapy approaches are lacking efficacy in the treatment of glioblastoma (GBM). In this study, we sought to reverse local and systemic GBM-induced immunosuppression using Helicobacter pylori neutrophil-activating protein (NAP), a potent TLR2 agonist, as an immunostimulatory transgene expressed oncolytic measles virus (MV) platform, retargeted allow viral entry through urokinase-type plasminogen activator receptor (uPAR). While single-agent murine anti-PD1 or repeat situ...
// Vassiliki Kotoula 1,2 , Kyriakos Chatzopoulos 2 Sotiris Lakis Zoi Alexopoulou 3 Eleni Timotheadou 4 Flora Zagouri 5 George Pentheroudakis 6 Helen Gogas 7 Galani 8 Ioannis Efstratiou 9 Thomas Zaramboukas Angelos Koutras 10 Gerasimos Aravantinos 11 Epaminontas Samantas 12 Amanda Psyrri 13 Kourea 14 Mattheos Bobos Pavlos Papakostas 15 Paris Kosmidis 16 Dimitrios Pectasides 17 and Fountzilas 1 Department of Pathology, Aristotle University Thessaloniki School Medicine, Thessaloniki, Greece...
Over the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type melanoma, perception shifted towards recognizing as spectrum comprising nevi, melanocytomas, and melanomas. are known for posing significant diagnostic challenge regarding distinction between benign neoplasms displaying atypical traits A comprehensive their molecular basis genomic aberrations significantly improved precision in classifying diagnosing these...
Abstract In patients with metastatic melanoma, high blood levels of galectin‐9 are correlated worse overall survival and a bias towards Th2 inflammatory state supportive tumor growth. Although signaling through TIM3 on T cells has been described, less is known about the interaction macrophages. We aimed to determine whether binding partner CD206 macrophages result this tumor‐supportive. It was determined that incubation CD68 + or anti‐CD206 blocked target both were detected by...
To evaluate the prognostic significance of tumor infiltrating lymphocytes (TILs) and CD8+ T-cell subsets in patients with surgically treated laryngeal squamous cell carcinoma (LSCC), LSCC from 283 were examined. TIL density was morphologically assessed on whole sections. counts/mm2 evaluated multiple tissue microarray cores per (median counts for high/low CD8+/mm2). weakly correlated each other (Spearman's rho = 0.348). Heterogeneous demonstrated 28% tumors. In univariate analysis, a...
Abstract Background Buccal squamous cell carcinoma (SCC) is a locoregionally aggressive malignancy, representing small subset of oral cancers in North America. We investigated the prognostic value several clinicopathologic factors cohort patients diagnosed with buccal SCC. Methods Between years 1992 and 2017, 52 were conventional Archival surgical pathology material was retrospectively reviewed for reportable findings according to latest reporting guidelines published by College American...
The aim of this study was to investigate the prognostic value Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison a panel proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN MMR) previously suggested be involved pathogenesis endometrial cancer, association with clinical outcome standard clinicopathological characteristics. A total 204 patients histological diagnosis cancer treated from 2004 2013 were included. evaluation protein expression...
Ceruminous adenomas are benign tumors that rare in humans and present with a nonspecific symptomatology. The treatment of choice is surgical excision. We an 87-year-old woman who presented reddish, tender, round, soft mass the outer third inferior wall left external auditory canal, discharging yellowish fluid upon pressure. Coincidentally, due to her poor general condition, this patient also showed symptoms consistent chronic otitis media, parotitis, cervical lymphadenopathy, such as...
Stromal tumor infiltrating lymphocytes (TILs) density is an outcome predictor in triple-negative breast cancer (TNBC). Herein we asked whether TILs are related to coding mutation load and the chemical class of resulting mutated amino acids, i.e., charged, polar, hydrophobic mutations.We examined paraffin tumors from TNBC patients who had been treated with adjuvant chemotherapy mostly within clinical trials (training cohort, N = 133; validation, 190) for phenotype concordance; density;...
To investigate the clinicopathologic and radiologic features of pulmonary hamartomas (PHs) with uncommon clinical presentation.A retrospective review was performed for patients diagnosed (1999-2019) multiple hamartomas, lesions arising adjacent to a coexisting malignancy, tumors predominantly extrapulmonary localization.Of 979 PHs, 6 (0.6%) had 4 (0.4%) lung adenocarcinoma, 2 (0.2%) large mediastinal masses. Patients median age 65 years mean tumor size 0.9 cm; 1 patient 3 5 2. Lesions next...
Aims Pulmonary chondromas, which are rare cartilaginous neoplasms that often arise in the setting of Carney triad, morphologically similar to pulmonary hamartomas, much more common. There is evidence succinate dehydrogenase (SDH) deficiency drives neoplasia patients with and SDHB immunohistochemistry can be used as a surrogate marker detect SDH deficiency. The aim this study was investigate utility distinguishing chondromas from hamartomas. Methods results Immunohistochemistry for (clone...
Age may pertain to different tumor genotype characteristics which interfere with treatment efficacy and prognosis. We investigated the distribution prognostic effect of mutations infiltrating lymphocyte (stromal TIL density) in young (≤35 years) elderly (>65 early breast cancer patients.Paraffin genotypes all clinical subtypes from 345 patients were examined.A total 638 detected 221 (64.1%). Compared young, presented lower density (p<0.001) but more TILs TP53 mutated tumors (p=0.042)....