A5030109945- PARP inhibition in cancer therapy
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- DNA Repair Mechanisms
- Chemotherapy-induced cardiotoxicity and mitigation
- Blood Pressure and Hypertension Studies
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Angiogenesis and VEGF in Cancer
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Cardiovascular Health and Disease Prevention
National and Kapodistrian University of Athens
2021-2025
Hellenic Cooperative Oncology Group
2017-2024
University General Hospital Attikon
2021-2023
Data on the effectiveness and safety of approved SARS-CoV-2 vaccines in cancer patients are limited. This observational, prospective cohort study investigated humoral immune response to vaccination 232 from 12 HeCOG-affiliated oncology departments compared 100 healthcare volunteers without known active cancer. The seropositivity rate was measured 2–4 weeks after two vaccine doses, by evaluating neutralising antibodies against spike protein using a commercially available immunoassay....
Chemotherapy, when added to radiotherapy, improves survival in locally advanced nasopharyngeal carcinoma (NPC). This article presents the second update of Meta-Analysis Chemotherapy NPC.Published or unpublished randomized trials assessing radiotherapy (±a chemotherapy timing) with/without non-metastatic NPC patients were identified. Updated data sought for studies included previous rounds meta-analysis. The primary endpoint was overall survival. All analyzed following intent-to-treat...
Data on the safety and efficacy of immune checkpoint inhibitors (ICI) in patients with concurrent autoimmune diseases (AID) are limited.We performed a retrospective multicenter review medical records cancer underlying AID who received ICI. The primary endpoint was progression-free survival (PFS).Among 123 pre-existing ICI, majority had been diagnosed non-small cell lung (NSCLC, 68.3%) melanoma (14.6%). Most rheumatologic (43.9%), or an endocrine disorder (21.1%). Overall, 74 (60.2%)...
Prevention of bone metastases is a major issue for breast cancer patients, as it would improve quality life in population where long survival anticipated.Early who had been treated with anthracycline-based chemotherapy within two randomized trials, were included the study. We evaluated, by quantitative reverse transcription-polymerase chain reaction, 819 formalin-fixed paraffin-embedded tumor tissue samples mRNA expression RANK, OPG, and RANKL, well their ratios, potential prognostic...
We explored the clinical significance of tumor genotypes and immunophenotypes in non-metastatic colorectal cancer (CRC).In primary tumors (paraffin blocks) from 412 CRC patients treated with adjuvant chemotherapy, we examined pathogenic mutations (panel NGS; 347 informative); mismatch repair (MMR) immunophenotype (360 CD8+ lymphocyte density (high - low; informative). The outcome measure was disease-free survival (DFS).We evaluated 1713 (median: 3 per tumor; range 0-49); 118/412 (28.6%)...
Background: Trastuzumab is a monoclonal antibody against HER2-positive breast cancer. Despite improving the natural history of disease, there number patients who are resistant to it, whereas all will eventually develop resistance and disease progress. Inconsistent preclinical data show that IGF-R pathway may contribute either de novo or acquired trastuzumab. Materials Methods: In total, 227 trastuzumab-treated metastatic cancer were evaluated for IGF-1, IGF-1R, GLP-1R, Akt1, Akt2 Akt3 mRNA...
Our aim was to determine the prevalence, prognostic and predictive role of germline pathogenic/likely pathogenic variants (P/LPVs) in cancer predisposing genes patients with pancreatic ductal adenocarcinoma (PDAC). Germline testing 62 susceptibility performed on unselected diagnosed from 02/2003 01/2020 PDAC, treated at Hellenic Cooperative Oncology Group (HeCOG)-affiliated Centers. The main endpoints were prevalence P/LPVs overall survival (OS). PDAC-associated homologous recombination...
Dose-dense sequential (dds) chemotherapy has changed the clinical outcome of patients with early breast cancer (BC). To investigate impact dose intensity (DI) in adjuvant setting BC, this observational trial (HE 10/10) was conducted assessing long-term survival outcome, safety and toxicity a currently widely used chemotherapeutic regimen. In addition, prognostic significance tumor infiltrating lymphocytes (TILs) CD8
This study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were treatment with UCB-PL (UCB-PL group, n = 52) every three days for one month or dressing normal saline (control 58). All participants followed up 20 weeks post treatment. Ulcer surface area assessed imitoMeasure application at two, four, and six weeks, four...
Background/Aim: Early-stage colorectal cancer (CRC) carries a wide range of survival probabilities. Novel biomarkers in this setting are eagerly awaited. Cancer stem cells (CSCs) considered one the reasons for treatment failure. This study sought to determine whether activation pathways governing function CSC9s could correlate with outcomes. Materials and Methods: Tumor specimens from 325 patients were analyzed immunohistochemistry (IHC) Hedgehog Notch pathway results correlated prognosis....
BACKGROUND: High grade glioma molecular profiling is of particular interest in neurooncology. The role telomerase reverse transcriptase (TERT) varies dependent upon other parameters. We explored the TERT 101 high-grade gliomas. METHODS: A total patients (pts) with III–IV gliomas treated standard care and informative tumor genotypes were included present study. Of 55 genes targeted next-generation sequencing panel, mutations (muts) found 37; these analysis. mut tested Sanger sequencing. MGMT...
Purpose: We conducted a phase II randomized noncomparative window of opportunity (WOO) trial to evaluate the inhibition cellular proliferation and modulation immune microenvironment after treatment with olaparib alone or in combination cisplatin durvalumab patients operable head neck squamous cell carcinoma (HNSCC). Experimental Design: Forty-one HNSCC were plus (arm A), B), no C) D). The primary endpoint was percentage each arm that achieved reduction at least 25% Ki67. Secondary endpoints...
The retinoblastoma (RB) gene is a tumor-suppressor that plays central role in regulating the cell cycle. Inactivation of this involved breast cancer.A total 827 patients with cancer treated taxane-based adjuvant chemotherapy were included study. Protein expression RB, phosphorylated RB (pRB), p16, cyclin D1 and p53 was evaluated by immunohistochemistry.Neither markers (RB pRB) reached statistical significance terms their association disease-free or overall survival. Nevertheless, when...
Cabazitaxel is a novel taxane that might be active in breast cancer resistant to first-generation taxanes.The purpose of the current multicentre phase II trial was evaluate activity and safety cabazitaxel, as second-line treatment, patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic (MBC) previously treated taxanes. The primary endpoint objective response rate (ORR).Eighty-four were enrolled between October 2012 November 2016. Taxane resistance previous...
Background/Aim: Ovarian cancer (OVCA) is characterized by genomic/molecular intra-patient heterogeneity (IPH). Tissue histology and morphological features are surrogates of the underlying contexture. We assessed IPH OVCA tumor compartments lymphocytic infiltrates in multiple matched samples per patient. Materials Methods: examined 294 hematoxylin & eosin (H&E) whole sections from 70 treatment-naïve patients who had undergone cytoreductive surgery. subtypes as immunoreactive (IR),...