A5047332527- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Imaging and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Hemodynamic Monitoring and Therapy
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Atherosclerosis and Cardiovascular Diseases
- S100 Proteins and Annexins
- Blood properties and coagulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Clinical Laboratory Practices and Quality Control
- Systemic Lupus Erythematosus Research
- Apelin-related biomedical research
- Diet and metabolism studies
- Renal function and acid-base balance
- GDF15 and Related Biomarkers
- Paraoxonase enzyme and polymorphisms
National and Kapodistrian University of Athens
2016-2025
University General Hospital Attikon
2015-2025
Hippocration General Hospital
2021-2023
Institute for Language and Speech Processing
2022
Athena Research and Innovation Center In Information Communication & Knowledge Technologies
2022
Endocrinology Research Center
2017
University of Ioannina
2014
Athens Medical Center
2005
Background We investigated the effects of insulin, glucagon‐like peptide‐1 receptor agonists ( GLP ‐1 RA ), sodium‐glucose cotransporter‐2 inhibitors SGLT ‐2i), and their combination on vascular cardiac function patients with type 2 diabetes mellitus. Methods Results A total 160 mellitus were randomized to insulin (n=40), liraglutide empagliflozin or + ‐2i) (n=40) as add‐on metformin. measured at baseline 4 12 months posttreatment: (a) perfused boundary region sublingual arterial...
We investigated the effects of anakinra, an interleukin-1 receptor antagonist, on coronary and left ventricular function in artery disease (CAD) patients with rheumatoid arthritis.In a double-blind crossover trial, 80 arthritis (60 CAD 20 without) were randomized to single injection anakinra or placebo after 48 hours alternative treatment. At baseline 3 treatment, we assessed (1) flow-mediated dilation brachial artery; (2) flow reserve, ejection fraction, systemic arterial compliance,...
Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated changes arterial stiffness left ventricular (LV) myocardial deformation after 6-month with GLP-1 analogue liraglutide subjects newly diagnosed T2DM.We randomized 60 patients treatment-naive T2DM to receive either (n = 30) or metformin for 6 months. measured at baseline treatment: (a) carotid-femoral pulse wave velocity (PWV) (b) LV longitudinal strain (GLS), rate (GLSR), peak...
The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Τhe aim our study was to evaluate the effectiveness a Mediterranean (MD) Ketogenic (KD), in patients with PSO PSA. Twenty-six were randomly assigned start either MD or KD for period 8 weeks. After 6-week washout interval, two groups crossed over other type At end this study, resulted significant reduction weight (p = 0.002, p < 0.001, respectively), BMI 0.006, waist circumference (WC) total...
Interleukin (IL)-12 activity is involved in the pathogenesis of psoriasis and acute coronary syndromes. We investigated effects IL-12 inhibition on vascular left ventricular (LV) function psoriasis.One hundred fifty patients were randomized to receive an anti-IL-12/23 (ustekinumab, n=50), anti-tumor necrosis factor-a (TNF-α; etanercept, or cyclosporine treatment (n=50). At baseline 4 months post-treatment, we measured (1) LV global longitudinal strain, twisting, percent difference between...
We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives 160 controls. measured perfused boundary region ( PBR ) sublingual microvessels, a marker inversely related thickness, flow reserve CFR ), Global Longitudinal strain GLS by echocardiography, pulse wave velocity PWV central systolic blood pressure cSBP ). Hypertensives had higher , lower than...
The Universal Morphology (UniMorph) project is a collaborative effort providing broad-coverage instantiated normalized morphological inflection tables for hundreds of diverse world languages. comprises two major thrusts: language-independent feature schema rich annotation and type-level resource annotated data in languages realizing that schema. This paper presents the expansions improvements made on several fronts over last couple years (since McCarthy et al. (2020)). Collaborative efforts...
Background and Objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RA) sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are cardioprotective drugs. We investigated their effects on left atrial function, a major determinant of cardiac diastolic dysfunction in type 2 diabetes mellitus. also explored the association changes arterial stiffness with those LA strain after treatment. Materials Methods: A total 200 patients (59.5 ± 9.1 year old, 151 male) mellitus treated metformin were...
Inflammatory responses in small vessels play an important role the development of cardiovascular diseases, including hypertension, stroke, and vessel disease. This involves various complex molecular processes oxidative stress, inflammasome activation, immune-mediated responses, protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, DNA methylation, histone modifications, microRNAs influence vascular inflammation injury. These phenomena may be...
Arterial elastance to left ventricular ratio assessed by echocardiography is widely used as a marker of ventricular-arterial coupling.We investigated whether the carotid-femoral pulse wave velocity, arterial stiffness, global longitudinal strain, performance, could be better associated with vascular and cardiac damage than established elastance/left index. In 299 newly-diagnosed untreated hypertensives we measured, carotid intima-media thickness, coronary-flow reserve, elastance, markers...
Hydroxytyrosol reduces low-density lipoprotein oxidation, contributing to prevention of atherosclerosis progression.In a prospective, crossover, double-blind, placebo-controlled trial, 30 chronic coronary artery syndrome (CCAS) patients were randomized 4 capsules/day, containing 412.5 mg olive oil with 2.5 hydroxytyrosol (OOHT) each one or placebo for 1 month and then crossed over the alternate treatment (placebo OOHT). We measured (a) perfused boundary region (PBR) sublingual arterial...
Abstract Background/Introduction Coronavirus disease 2019 (COVID-19) has been associated with impaired subclinical markers of endothelial and vascularfunction. Purpose We investigated whether intervention Endocalyx (Microvascular Health Solutions),a dietary supplement containing glycosaminoglycans fucoidan, can improve glycocalyx integrity,arterial stiffness, coronary microcirculationin patients after COVID-19 infection. Methods Fiftypatients within 15 days a confirmed mild-to-moderate...
Abstract Background/Aim HIV infection is related with cardiovascular adverse events. We investigated the effects of antiretroviral treatment in myocardial and vascular function newly diagnosed patients HIV. Patients methods: A total 70 were enrolled. randomized to 4 different treatments which descovy plus resolsta (emtricitabine/ tenofovir alafenamide), tivicay (tenofovir alafenamide/ emtricitabine), genvoya (elvitegravir, cobicistat, emtricitabine alafenamide) isentress (raltegravir)....
Abstract Introduction In a recent study, we demonstrated that the administration of an olive oil supplement enriched with HT (Olivomed) reduces oxidative stress and inflammatory biomarkers, improves endothelial arterial function, facilitates diastolic function left ventricle after short treatment period in patients chronic coronary syndromes. Objetive Wehypothesized oral supplement, Olivomed SMART, containing extract oleuropein (OL), hydroxytyrosol (HT) oleocanthal (OLEO), can reduce burden...
Abstract Background/Introduction Psoriatic disease is associated with impaired endothelial and vascular function. Purpose We investigated whether intervention Endocalyx (Microvascular Health Solutions),a dietary supplement containing glycosaminoglycans fucoidan, can improve glycocalyx integrity arterial stiffness in patients psoriatic disease. Methods Thirty were randomized to receive (n=15) or placebo for 4 months. measured at baseline months of treatment: a)perfused boundary region(PBR)...
Background We investigated the effects of combined treatment with glucagon like peptide‐1 receptor agonists (GLP‐1RA) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2i) on NT‐proBNP (N‐terminal pro‐brain natriuretic peptide), GDF‐15 (growth differentiation factor 15), MOTS‐c (mitochondrial‐derived peptide‐c) in patients type 2 diabetes (T2D) high or very cardiovascular risk. Methods studied 163 consecutive who were treated insulin (n=40), liraglutide (n=41), empagliflozin (n=42), their...
Purpose: Pulse wave velocity (PWV) is a marker of arterial stiffness with major prognostic value. We compared Arteriograph and Complior devices the Mobil-O-Graph for assessment PWV central systolic blood pressure (cSBP).Materials Methods: studied 316 consecutive subjects (age: 55 ± 14 years). For each individual, we measured cSBP Arteriograph, readings. Differences in values among three were calculated measurement. used Bland-Altman analysis, intraclass correlation coefficient (ICC)...