A5070802022- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Alzheimer's disease research and treatments
- Parathyroid Disorders and Treatments
- Menopause: Health Impacts and Treatments
- Hormonal and reproductive studies
- Multiple Myeloma Research and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
Alexandra Hospital
2016-2025
National and Kapodistrian University of Athens
2016-2025
Newcastle University
2019-2025
Centre for Life
2024
Stamatopoulos and Associates (Greece)
2016-2024
Örebro University
2023
Linköping University
2023
Linköping University Hospital
2023
Örebro University Hospital
2023
Hippocration General Hospital
2023
In a recent study of our group with the acronym ACTIVATE, Bacillus Calmete-Guérin (BCG) vaccination reduced occurrence new infections compared to placebo in elderly. Most benefit was found for respiratory infections. The ACTIVATE-2 launched assess efficacy BCG against coronavirus disease 2019 (COVID-19). this multicenter, double-blind trial, 301 volunteers aged 50 years or older were randomized (1:1) be vaccinated placebo. trial end points incidence COVID-19 and presence anti–severe acute...
Clinical trials with carfilzomib have indicated a low but reproducible incidence of cardiovascular and renal toxicities. Among 60 consecutive myeloma patients treated carfilzomib-based regimens who were thoroughly evaluated for risk factors, 12% (95% confidence interval, 3.8%-20%) experienced reversible reduction left ventricular ejection fraction (LVEF) by ≥20%, an objective measure cardiac dysfunction. The LVEF was 5% at 3 months, 8% 6 10% 12 15 whereas the respective discontinuation rate...
Long non-coding RNAs (lncRNAs) have emerged as critical regulators in human disease including atherosclerosis. However, the mechanisms involved post-transcriptional regulation of expression disease-associated lncRNAs are not fully understood. Gene studies revealed that Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) lncRNA was increased by >2-fold peripheral blood mononuclear cells (PBMCs) derived from patients with coronary artery (CAD) or carotid atherosclerotic plaques. We observed a...
Thyroid function parameters have been associated with obesity, but associations the type of adiposity not examined. We used ultrasound (US) to assess regional and investigated thyroid central obesity.Cross-sectional study.A total 303 apparently healthy individuals (age 42.9+/-8.8, body mass index (BMI) 19.0-43.3, median 26.2 kg/m(2), 181 women) were examined for indices metabolic syndrome. BMI, waist hip circumference, abdominal subcutaneous fat (SF), preperitoneal (PF) layer was estimated....
Adenosine-to-inosine (A-to-I) RNA editing of Alu retroelements is a primate-specific mechanism mediated by adenosine deaminases acting on (ADARs) that diversifies transcriptome changing selected nucleotides in molecules. We tested the hypothesis A-to-I altered rheumatoid arthritis (RA). Synovium expression analysis ADAR1 was investigated 152 RA patients and 50 controls. Peripheral blood mononuclear cells derived from 14 healthy subjects 19 with active at baseline after 12-week treatment were...
Inflammatory responses in small vessels play an important role the development of cardiovascular diseases, including hypertension, stroke, and vessel disease. This involves various complex molecular processes oxidative stress, inflammasome activation, immune-mediated responses, protein misfolding, which together contribute to microvascular damage. In addition, epigenetic factors, DNA methylation, histone modifications, microRNAs influence vascular inflammation injury. These phenomena may be...