A5058528410- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Single-cell and spatial transcriptomics
- RNA Research and Splicing
- Respiratory viral infections research
- Advanced Glycation End Products research
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Dementia and Cognitive Impairment Research
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- SARS-CoV-2 detection and testing
- Health, Environment, Cognitive Aging
- Viral Infections and Immunology Research
Newcastle University
2020-2025
Long non-coding RNAs (lncRNAs) have emerged as critical regulators in human disease including atherosclerosis. However, the mechanisms involved post-transcriptional regulation of expression disease-associated lncRNAs are not fully understood. Gene studies revealed that Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) lncRNA was increased by >2-fold peripheral blood mononuclear cells (PBMCs) derived from patients with coronary artery (CAD) or carotid atherosclerotic plaques. We observed a...
Spatial transcriptomics (ST) has the potential to provide unprecedented insights into gene expression across tissue architecture, but existing analytical methods often overlook full complexity of spatial dimension. We present STExplorer, an R package that adapts well-established computational geography (CG) explore micro-geography omics data. By incorporating techniques like Geographically Weighted Principal Component Analysis (GWPCA), Fuzzy Clustering (FGWC), Regression (GWR), and analyses...
Adenosine deaminase acting on RNA-1 (ADAR1) enzyme is a type I interferon (IFN)-stimulated gene (ISG) catalyzing the deamination of adenosine-to-inosine, process called A-to-I RNA editing. editing takes place mainly in Alu elements comprising primate-specific level post-transcriptional regulation. Whether involved IFN responses systemic sclerosis (SSc) patients remains unknown.ISG expression was quantified skin biopsies and peripheral blood mononuclear cells derived from SSc healthy...
Abstract. Spatial data, data with some form of location attached, are the norm: all spatial now. However requires consideration three critical characteristics, observation auto-correlated, process spatially non-stationarity and effect MAUP. Geographers familiar these have tools, rubrics workflows to accommodate them understand their impacts on statical inference, understanding prediction. However, increasingly researchers in non geographical domains, no experience of, or exposure...
The COVID-19 pandemic has been a huge challenge for the Greek National Health System. Real-time reverse transcription PCR (rtRT-PCR) remains reference method early diagnosis, contact tracing, and containment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). aim this study is documentation epidemiological features SARS-CoV-2 laboratory surveillance with rtRT-PCR in population residing Pieria province Greece. Of 15,486 nasopharyngeal oropharyngeal samples tested real-time...