A5008442853- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Heart rate and cardiovascular health
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Sodium Intake and Health
- Neuroscience of respiration and sleep
- Cardiac Health and Mental Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Inflammasome and immune disorders
- Obstructive Sleep Apnea Research
- Apelin-related biomedical research
- Eicosanoids and Hypertension Pharmacology
- Lipoproteins and Cardiovascular Health
University of Milano-Bicocca
2016-2025
Azienda Ospedaliera San Gerardo
2008-2023
IRCCS Istituto Auxologico Italiano
2003-2011
MultiMedica
2009-2011
Ospedale Bassini
2011
Université Laval
2010
Istituti di Ricovero e Cura a Carattere Scientifico
2009
Azienda Ospedaliera Ospedale Civile di Legnano
2009
Medica (Italy)
2008
Sapienza University of Rome
2007
It is debated whether white-coat (WCHT) and masked hypertension (MHT) are at greater risk of developing a sustained hypertensive state (SHT). In 1412 subjects the Pressioni Arteriose Monitorate e Loro Associazioni Study, we measured office blood pressure (BP), 24-hour ambulatory BP, home BP. The condition WCHT was identified as BP >140/90 mm Hg mean <125/79 or <132/82 Hg. Corresponding values for MHT diagnosis were <140/90 Hg, ≥125/79 ≥132/82 SHT when both means over threshold...
Direct and indirect indices of neuroadrenergic function have shown that end-stage renal disease is characterized by a marked sympathetic overdrive. It unknown, however, whether this phenomenon represents peculiar feature or it also detectable in the early clinical phases disease. The study has been performed 73 hypertensive patients, which there were 42 (age: 60.7±1.8 years, mean±SEM) with stable moderate chronic failure (mean estimated glomerular filtration rate: 40.7 mL/min per 1.73 m2,...
Limited information is available on whether and to what extent the different patterns of nocturnal blood pressure profile reported in hypertension are characterized by differences sympathetic drive that may relate to, account for, day-night changes. In 34 untreated middle-aged essential hypertensive dippers, 17 extreme 18 nondippers, 10 reverse we assessed muscle nerve traffic, heart rate, beat-to-beat arterial at rest during baroreceptor deactivation stimulation. Measurements were also...
The sympathetic overdrive that characterizes essential hypertension is potentiated when left ventricular hypertrophy or congestive heart failure detected. No information exists, however, on whether this the case also for diastolic dysfunction. In 17 untreated hypertensive subjects with dysfunction (age: 47.7+/-2.9 years, mean+/-SEM), we measured nerve traffic (microneurography), rate (ECG), and beat-to-beat arterial blood pressure (Finapres) at rest during baroreceptor deactivation...
Previous studies have shown that left ventricular hypertrophy (LVH) represents a cardiovascular risk factor independently of clinic blood pressure (BP). The present study was aimed at determining the impact LVH on incidence morbid and fatal events taking into account not only classical factors but also home ambulatory BP values, which been to an important independent prognostic impact.In 1716 patients belonging 'Pressioni Arteriose Monitorate E Loro Associazioni' population Monza, we...
The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society Hypertension conceived designed an ad-hoc study aimed at searching for prognostic cut-off values serum uric acid (SUA) in predicting fatal myocardial infaction (MI) women men.The URic Right heArt Health is a nationwide, multicentre, observational cohort involving data individuals aged 18-95 years recruited regional community basis from all territory Italy under patronage with mean follow-up period 122.3 ± 66.9...
In the frame of Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on regional community basis from all territory Italy under patronage Working Group and Cardiovascular Risk Italian Society Hypertension, we searched cut-off values ratio between serum uric acid (SUA) creatinine (sCr) able to predict cardiovascular (CV) events.Among 20 724 followed-up 126 ± 64 months, after detecting by receiver operating characteristic curves,...
Abstract Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered surrogate marker of insulin resistance (IR); in addition, it estimated to be better expression IR than widely used tools. Few and heterogeneous data are available on the relationship between this mortality risk non-Asian populations. Therefore, we predictive role baseline TyG incidence all-cause cardiovascular (CV) large sample general population. Moreover, consideration well-recognized serum uric...
Obese persons are at increased cardiovascular risk and exhibit arterial stiffness impaired endothelial function of large- medium-size arteries. We hypothesized that normotensive subjects suffering from severe obesity would also present remodeling dysfunction small resistance A total 16 lean (age: 49.6 +/- 2.9 years, BMI: 22.9 0.3 kg/m(2), mean s.e.m.) 17 age-matched severely obese (BMI: 41.1 2.3 kg/m(2)) were investigated. None had glucose or lipid metabolic abnormalities except for insulin...
Congestive heart failure is characterized by sympathetic activation, which has also been described in the metabolic syndrome. No information exists, however, as to whether sympathostimulating effects of these 2 conditions summate when complicated syndrome, leading an exceedingly high adrenergic drive. This clinically relevant, because activation closely related mortality. We studied 48 control subjects (age: 58.4±1.6 years, mean±SEM) and 89 age-matched patients (New York Heart Association...
A sustained blood pressure elevation is associated with an increased risk of new-onset diabetes mellitus. Whether this the case also in white-coat and masked hypertension unknown.In 1412 individuals Pressioni Arteriose Monitorate E Loro Associazioni study stratified for sex age decades, we measured office, home 24-h ambulatory together fasting plasma glucose other metabolic variables. This allowed to identify patients white-coat, masked, true normotension.Over a 10-year period, increase...
Vascular inflammation plays an important role in the pathophysiology of hypertension and high levels endocan may reflect ongoing vascular hypertensive patients. In present hypothesis-generating study, we aimed at investigating comparative effects amlodipine valsartan on newly diagnosed The study population consisted 37 untreated patients who were randomized to two treatment arms. After baseline assessment, each patient was randomly allocated either 10 mg daily (n = 18, 7 males) or 160 19, 3...
Although several data suggest that serum uric acid (SUA) predicts future development of metabolic abnormalities, the evidence is not conclusive in Mediterranean populations.A total 3200 individuals were randomly selected from residents Monza (North Italy) to be representative its general population for sex and age (25-74 years). The participation rate was 64%. At baseline 10 years later, we measured waist circumference, office blood pressure, fasting glucose, triglycerides, HDL cholesterol...
Although abnormalities in reflex sympathetic neural function represent a hallmark of heart failure, no information is available on the neuroadrenergic and baroreflex failure with preserved, midrange reduced ejection fraction. The current study was designed to assess muscle nerve traffic (MSNA) clinical classes defined by new European Society Cardiology/American College Cardiology Foundation/American Heart Association guidelines.In 32 treated patients aged 69.3 ± 1.1 (mean SEM) classified...
Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on role of diuretic-related are still scanty. The present study was designed to collect information events. Methods: URic acid Right for heArt Health (URRAH) is a nationwide, multicentre, observational cohort involving individuals recruited from all Italy territory under patronage Italian Society Hypertension with an average follow-up period 122.3 ± 66.9 months. Patients...
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in presence of normal high TG has never been investigated. We included 8124 patients from URic Right for heArt Health (URRAH) study cohort who were followed over 20 years had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) (CVM) explored by Kaplan-Meier estimator Cox...
Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, exact level at which risk begins to rise is unclear. The Working Group Uric Acid Cardiovascular Risk of Italian Society Hypertension has conceived a protocol aimed searching for prognostic cutoff value in predicting events large regional-based cohort.