Marcello Rattazzi
A5052790351- Gout, Hyperuricemia, Uric Acid
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Parathyroid Disorders and Treatments
- Lipoproteins and Cardiovascular Health
- Atherosclerosis and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Venous Thromboembolism Diagnosis and Management
- Inflammasome and immune disorders
- COVID-19 Clinical Research Studies
- Dermatological and Skeletal Disorders
- Psoriasis: Treatment and Pathogenesis
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- Bone Metabolism and Diseases
- Infective Endocarditis Diagnosis and Management
- Aortic Thrombus and Embolism
- Diet and metabolism studies
- Nutritional Studies and Diet
University of Padua
2016-2025
Ca' Foncello Hospital
2016-2025
European Society of Hypertension
2019-2024
Federico II University Hospital
2014-2023
Azienda di Rilievo Nazionale ed Alta Specializzazione
2023
Minnesota Department of Health
2014
University of Minnesota
2014
Centro Cardiologico Monzino
2014
University of Insubria
2014
Medical University of Vienna
2014
Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed threshold SUA that increases total mortality and (CVM). The URRAH study (Uric Acid Right for Heart Health) multicentre retrospective, observational study, which collected data from several longitudinal studies in Italy subjects recruited hypertension clinics Italian Society Hypertension. Total was defined as any cause,...
Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) superfamily proteins, plays an important role in bone remodeling and is expressed both mouse human atherosclerotic lesions. The current study was designed to assess whether OPG progression calcification advanced lesions apoE(-/-) mice.Atherosclerotic lesion area composition aortic calcium content were examined mice deficient apolipoprotein E (OPG(-/-).apoE(-/-) mice) at 20, 40, 60 weeks age. Littermate OPG(+/+).apoE(-/-) used...
Acquisition of a procalcific phenotype by resident or circulating cells is important for calcification atherosclerotic plaques, which common in diabetes.We aim to identify and characterize calcifying cells, delineate pathophysiological role these type 2 demonstrate the first time that distinct subpopulation expressing osteocalcin bone alkaline phosphatase (OC(+)BAP(+)) has activity vitro vivo. The study naïve patients with chronic myeloid leukemia indicated OC(+)BAP(+) have origin. Myeloid...
Chronic kidney disease (CKD) is a major risk factor for valvular heart (VHD). Mitral annular and aortic valve calcifications are highly prevalent in CKD patients commonly lead to stenosis regurgitation, as well complications including conduction system abnormalities endocarditis. VHD, especially mitral regurgitation stenosis, associated with significantly reduced survival among patients. Knowledge related VHD the general population not always applicable because pathophysiology may be...
Abstract BACKGROUND The effect of chronic use renin–angiotensin–aldosterone system (RAAS) inhibitors on the severity COVID-19 infection is still unclear in patients with hypertension. We aimed to investigate association between angiotensin-converting enzyme (ACEIs) or angiotensin II receptor blockers (ARBs) and COVID-19-related outcomes hypertensive patients. METHODS A single-center study was conducted 133 consecutive subjects presenting emergency department acute respiratory symptoms and/or...
The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society Hypertension conceived designed an ad-hoc study aimed at searching for prognostic cut-off values serum uric acid (SUA) in predicting fatal myocardial infaction (MI) women men.The URic Right heArt Health is a nationwide, multicentre, observational cohort involving data individuals aged 18-95 years recruited regional community basis from all territory Italy under patronage with mean follow-up period 122.3 ± 66.9...
In the frame of Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on regional community basis from all territory Italy under patronage Working Group and Cardiovascular Risk Italian Society Hypertension, we searched cut-off values ratio between serum uric acid (SUA) creatinine (sCr) able to predict cardiovascular (CV) events.Among 20 724 followed-up 126 ± 64 months, after detecting by receiver operating characteristic curves,...
Abstract Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered surrogate marker of insulin resistance (IR); in addition, it estimated to be better expression IR than widely used tools. Few and heterogeneous data are available on the relationship between this mortality risk non-Asian populations. Therefore, we predictive role baseline TyG incidence all-cause cardiovascular (CV) large sample general population. Moreover, consideration well-recognized serum uric...
Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, exact level at which risk begins to rise is unclear. The Working Group Uric Acid Cardiovascular Risk of Italian Society Hypertension has conceived a protocol aimed searching for prognostic cutoff value in predicting events large regional-based cohort.
Advanced atherosclerotic lesions in the innominate arteries of chow-fed apolipoprotein E-deficient mice become highly calcified with 100% frequency by 75 weeks age. The time course, cell types, and mechanism(s) associated calcification were investigated.The deposition hydroxyapatite is preceded formation fibro-fatty nodules that are populated cells morphologically resemble chondrocytes. These spatially small deposits animals between 45 60 Immunocytochemical analyses antibodies recognizing...
Objective: To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal and morbid heart failure a large Italian cohort frame Working Group on Uric Acid Cardiovascular Risk Society Hypertension. Methods: The URic Right for heArt Health (URRAH) study is nationwide, multicentre, involving data individuals aged 18–95 years, recruited community basis from all regions Italy under patronage Hypertension with mean follow-up period 128 ± 65 months. Incident was defined...
Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on role of diuretic-related are still scanty. The present study was designed to collect information events. Methods: URic acid Right for heArt Health (URRAH) is a nationwide, multicentre, observational cohort involving individuals recruited from all Italy territory under patronage Italian Society Hypertension with an average follow-up period 122.3 ± 66.9 months. Patients...
Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on mechanisms underlying excess cardiovascular mortality associated both hyperuricemia lead to risk stratification. Our main goal was study relationships between serum measures (namely estimated GFR [eGFR] albuminuria) large cohort individuals at from URic Right for...
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in presence of normal high TG has never been investigated. We included 8124 patients from URic Right for heArt Health (URRAH) study cohort who were followed over 20 years had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) (CVM) explored by Kaplan-Meier estimator Cox...
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some explored the role of creatinine (sCr)-normalized (SUA/sCr) ratio in different settings. Previously, URRAH (URic Right for heArt Health) Study has identified cut-off value this index to predict CV mortality at 5.35 Units. Therefore, given no SUA/sCr threshold risk been patients with diabetes, we aimed assess...
We studied 74 never-treated grade I hypertensive subjects aged 18 to 45 years and 20 normotensive control define the rate of increase in carotid intima-media thickness (IMT) potential role played by various risk factors. IMT was assessed as mean maximum right left common artery, bulb, internal artery at baseline 5-year follow-up. In subjects, both were significantly higher compared with values. Compared increased (at least P <0.01) each segment. The cumulative 3.4-fold for 3.2-fold IMT....