Luciano Lippa
A5013724941- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Heart rate and cardiovascular health
- Spondyloarthritis Studies and Treatments
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
Società Italiana di Medicina Generale
2019-2025
General Department of Preventive Medicine
2024
Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed threshold SUA that increases total mortality and (CVM). The URRAH study (Uric Acid Right for Heart Health) multicentre retrospective, observational study, which collected data from several longitudinal studies in Italy subjects recruited hypertension clinics Italian Society Hypertension. Total was defined as any cause,...
The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society Hypertension conceived designed an ad-hoc study aimed at searching for prognostic cut-off values serum uric acid (SUA) in predicting fatal myocardial infaction (MI) women men.The URic Right heArt Health is a nationwide, multicentre, observational cohort involving data individuals aged 18-95 years recruited regional community basis from all territory Italy under patronage with mean follow-up period 122.3 ± 66.9...
In the frame of Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on regional community basis from all territory Italy under patronage Working Group and Cardiovascular Risk Italian Society Hypertension, we searched cut-off values ratio between serum uric acid (SUA) creatinine (sCr) able to predict cardiovascular (CV) events.Among 20 724 followed-up 126 ± 64 months, after detecting by receiver operating characteristic curves,...
Abstract Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered surrogate marker of insulin resistance (IR); in addition, it estimated to be better expression IR than widely used tools. Few and heterogeneous data are available on the relationship between this mortality risk non-Asian populations. Therefore, we predictive role baseline TyG incidence all-cause cardiovascular (CV) large sample general population. Moreover, consideration well-recognized serum uric...
Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on role of diuretic-related are still scanty. The present study was designed to collect information events. Methods: URic acid Right for heArt Health (URRAH) is a nationwide, multicentre, observational cohort involving individuals recruited from all Italy territory under patronage Italian Society Hypertension with an average follow-up period 122.3 ± 66.9 months. Patients...
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in presence of normal high TG has never been investigated. We included 8124 patients from URic Right for heArt Health (URRAH) study cohort who were followed over 20 years had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) (CVM) explored by Kaplan-Meier estimator Cox...
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some explored the role of creatinine (sCr)-normalized (SUA/sCr) ratio in different settings. Previously, URRAH (URic Right for heArt Health) Study has identified cut-off value this index to predict CV mortality at 5.35 Units. Therefore, given no SUA/sCr threshold risk been patients with diabetes, we aimed assess...
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which turn, portends unfavourable prognosis.We assessed the prognostic role of SUA patients with and without MS.We used data from multicentre Uric Acid Right for Heart Health study considered cardiovascular mortality (CVM) death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.A total 9589 subjects (median age 58.5 years, 45% males) were included analysis,...
Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway IR, while IR is a known predictor for development of hyperuricemia. The triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker IR. This research aimed investigate interaction between glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk large...
A relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study.Aimof this study was to investigate association SUA left ventricular mass index (LVMI) whether LVMI or their combination may predict incidence of CV death.MethodsSubjects with echocardiographic measurement included URRAH (n=10733) were part analysis. LV hypertrophy (LVH) defined as > 95 g/m2 women 115 men.ResultsA significant observed multiple...
Objectives: In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated association SUA with all-cause and cardiovascular (CV) in adults participating large multicentre observational right heart health (URRAH) study. Methods: Eight thousand URRAH participants aged 65+ were included analysis. The predictive was assessed using Cox regression models stratified according to cut-off age 75. tested continuous categorical variable...
Abstract Aims Whether the association between uric acid (UA) and cardiovascular disease is influenced by some facilitating factors unclear. The aim of this study was to investigate whether risk mortality (CVM) associated with elevated UA modulated level resting heart rate (HR). Methods results Multivariable Cox analyses were made in 19 128 participants from multicentre Uric Right for heArt Health study. During a median follow-up 11.2 years, there 1381 cases CVM. In multivariable models both...
High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, HDL-C has been recently postulated. Subjects from the URic Right for heArt Health (URRAH) study with carotid ultrasound without previous cardiovascular diseases (CVD) (n = 6209), followed over 20 years, were included in analysis. Hypertriglyceridemia (hTG) was defined as TG ≥...
The objective of this study was to investigate the longitudinal association metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and effect LDL-cholesterol levels on association. This conducted 15,904 participants from URRAH grouped according BMI metabolic status. Healthy status identified without including LDL-cholesterol. risk MACE during 11.8 years follow-up evaluated multivariable Cox regressions. Among aged <70 years, high associated an increased...
<title>Abstract</title> Background Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway contributing IR, while IR is a known predictor for development of hyperuricemia. The triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker IR. This research aimed investigate interaction between glomerular filtration rate (GFR)-adjusted uricemia...