A5027465947- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Sodium Intake and Health
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Ultrasound in Clinical Applications
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Renal function and acid-base balance
- Obstructive Sleep Apnea Research
- Diabetes Treatment and Management
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Nitric Oxide and Endothelin Effects
Istituto di Fisiologia Clinica
2016-2025
National Academies of Sciences, Engineering, and Medicine
2005-2025
Ospedale Maggiore
2017-2025
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2010-2025
Metropolitan Hospital
2024-2025
IFC Research (United Kingdom)
2015-2025
University of Reggio Calabria
2015-2024
Leiden University Medical Center
2015-2024
Imperial College Healthcare NHS Trust
2024
Hammersmith Hospital
2024
ABSTRACT. Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro. Among human subjects, plasma ADPN concentrations are reduced among patients with atherosclerotic complications but substantially increased advanced renal failure. The clinical and biochemical correlates levels were investigated the predictive power respect to survival rates cardiovascular events was prospectively tested cohort 227 hemodialysis patients, who...
Background — Sympathetic tone is consistently raised in patients with end-stage renal disease (ESRD). We therefore tested the hypothesis that sympathetic activation associated mortality and cardiovascular events a cohort of 228 undergoing chronic hemodialysis who did not have congestive heart failure at baseline had left ventricular ejection fraction >35%. Methods Results The plasma concentration norepinephrine (NE) was used as measure activity. Plasma NE exceeded upper limit normal range...
High plasma asymmetrical dimethylarginine (ADMA) signals endothelial dysfunction and atherosclerosis in the general population predicts mortality ESRD. The relationship among levels of ADMA, renal function, risk for progression to ESRD (halving GFR or dialysis start) death an incident cohort 131 patients with chronic kidney disease was investigated. Cox's competing regression used model double-failure times (progression death) as a function ADMA. Covariates that were considered adjustment...
Previous studies have suggested the benefits of physical exercise for patients on dialysis. We conducted Exercise Introduction to Enhance Performance in Dialysis trial, a 6-month randomized, multicenter trial test whether simple, personalized walking program at home, managed by dialysis staff, improves functional status adult The main study outcomes included change performance 6 months, assessed 6-minute and five times sit-to-stand test, quality life, Kidney Disease Quality Life Short Form...
Sustained fluid overload (FO) is considered a major cause of hypertension, heart failure, and mortality in patients with ESRD on maintenance hemodialysis. However, there has not been cohort study investigating the relationship between chronic exposure to FO this population. We studied baseline cumulative over 1 year 39,566 incident large dialysis network 26 countries using whole-body bioimpedance spectroscopy assess status. Analyses were applied across three discrete systolic BP (syst-BP)...
Pulmonary congestion is highly prevalent and often asymptomatic among patients with ESRD treated hemodialysis, but whether its presence predicts clinical outcomes unknown. Here, we tested the prognostic value of extravascular lung water measured by a simple, well validated ultrasound B-lines score (BL-US) in multicenter study that enrolled 392 hemodialysis patients. We detected moderate-to-severe 45% very severe 14% Among those congestion, 71% were or presented slight symptoms heart failure....
Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed threshold SUA that increases total mortality and (CVM). The URRAH study (Uric Acid Right for Heart Health) multicentre retrospective, observational study, which collected data from several longitudinal studies in Italy subjects recruited hypertension clinics Italian Society Hypertension. Total was defined as any cause,...
Chronic kidney disease (CKD) in patients with diabetes mellitus (DM) is a major problem of public health. Currently, many these experience progression cardiovascular and renal disease, even when receiving optimal treatment. In previous years, several new drug classes for the treatment type 2 DM have emerged, including inhibitors sodium-glucose co-transporter-2 (SGLT-2) glucagon-like peptide-1 (GLP-1) receptor agonists. Apart from reducing glycaemia, were reported to other beneficial effects...
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis adrenalectomized and medically treated patients. We have, therefore, assessed outcome of PA patients according treatment mode PAPY study (Primary Aldosteronism Prevalence Hypertension) patients, 88.8% whom were optimally with primary (essential) hypertension (PH), rest had assigned medical therapy (6.4%) or adrenalectomy...
Chronic kidney disease (CKD) is a condition characterized by the gradual loss of function over time and it worldwide health issue. The estimated frequency CKD 10% world’s population, but varies greatly on global scale. In absolute terms, staggering number subjects affected various degrees 850,000,000, 85% them are in low- to middle-income countries. most important risk factors for chronic age, arterial hypertension, diabetes, obesity, proteinuria, dyslipidemia, environmental such as dietary...
ABSTRACT. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase that has been linked to endothelial dysfunction and atherosclerosis in the general population. ADMA also elevated end-stage renal disease may contribute high cardiovascular risk patients with chronic failure. A prospective cohort study was performed investigate relationship between plasma ADMA, C-reactive protein (CRP), intima-media thickness (IMT) 90 undergoing hemodialysis. In baseline...
Abstract. This study was designed to investigate the relationship among brain natriuretic peptide (BNP) and atrial (ANP) left ventricular mass (LVM), ejection fraction, LV geometry in a large cohort of dialysis patients without heart failure ( n = 246) test prediction power these peptides for total cardiovascular mortality. In separate multivariate models LVM, BNP ANP were strongest independent correlates LVM index. models, predictive slightly stronger than that ANP. Both also predictors...
ABSTRACT. Left ventricular hypertrophy (LVH) is exceedingly frequent in patients undergoing dialysis. Cardiac mass proportional to body size, but the influence of various indexing methods has not been studied with end-stage renal disease. The issue important because malnutrition and volume expansion would both tend distort estimate LV (LVM) these patients. In a cohort 254 patients, prognostic impact on all-cause mortality cardiovascular outcomes LVH values, calculated according two...
Inflammation is a major risk factor for mortality and cardiovascular (CV) complications in patients with ESRD. The predictive value of C-reactive protein (CRP) the main proinflammatory cytokines (IL-1β, IL-6, IL-18, TNF-α) two adhesion molecules (intercellular molecule-1 vascular cell molecule-1) 217 dialysis was compared. Serum IL-6 CRP added significant prediction power to multivariate Cox model all-cause death, gain attributable approximately times higher than that CRP. Patients third...