Carlo M. Barbagallo
A5030564855- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Cardiovascular Health and Disease Prevention
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Birth, Development, and Health
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
University of Palermo
2016-2025
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2003-2025
University of Catania
1995-2023
European Society of Hypertension
2019-2022
University of Padua
2017
University of Udine
2012
Policlinico Universitario di Catania
2007
Lawrence Berkeley National Laboratory
1998-2003
University of California, Berkeley
1999-2003
University of California, San Francisco
1999-2003
<h2>Summary</h2><h3>Background</h3> One of the global targets for non-communicable diseases is to halt, by 2025, rise in age-standardised adult prevalence diabetes at its 2010 levels. We aimed estimate worldwide trends diabetes, how likely it countries achieve target, and changes prevalence, together with population growth ageing, are affecting number adults diabetes. <h3>Methods</h3> pooled data from population-based studies that had collected on through measurement biomarkers. used a...
Serum uric acid (SUA) levels discriminating across the different strata of cardiovascular risk is still unknown. By utilizing a large population-based database, we assessed threshold SUA that increases total mortality and (CVM). The URRAH study (Uric Acid Right for Heart Health) multicentre retrospective, observational study, which collected data from several longitudinal studies in Italy subjects recruited hypertension clinics Italian Society Hypertension. Total was defined as any cause,...
Abstract Thromboxane A 2 (TXA ) biosynthesis is enhanced in the majority of patients with type IIa hypercholesterolemia. Because simvastatin (a 3-hydroxy-3-methylglutaryl coenzyme reductase inhibitor) was previously shown to reduce platelet aggregation and TXB production ex vivo, we investigated TXA function 24 hypercholesterolemia randomized receive a double-blind fashion (20 mg/d) or placebo for 3 months. The urinary excretion 11-dehydro-TXB , largely reflection measured by validated...
Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h in an oral tolerance test (2hOGTT), and HbA1c. We assessed effect diagnostic definitions both population prevalence diabetes classification previously undiagnosed individuals as having versus not a pooled analysis data from population-based health examination surveys regions.We used 96 that had measured at least two biomarkers for defining diabetes. was using HbA1c (HbA1c ≥6·5% or...
The Working Group on Uric Acid and Cardiovascular Risk of the Italian Society Hypertension conceived designed an ad-hoc study aimed at searching for prognostic cut-off values serum uric acid (SUA) in predicting fatal myocardial infaction (MI) women men.The URic Right heArt Health is a nationwide, multicentre, observational cohort involving data individuals aged 18-95 years recruited regional community basis from all territory Italy under patronage with mean follow-up period 122.3 ± 66.9...
In the frame of Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on regional community basis from all territory Italy under patronage Working Group and Cardiovascular Risk Italian Society Hypertension, we searched cut-off values ratio between serum uric acid (SUA) creatinine (sCr) able to predict cardiovascular (CV) events.Among 20 724 followed-up 126 ± 64 months, after detecting by receiver operating characteristic curves,...
Abstract Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We data from 117 population-based studies quantified, in world regions, the prevalence of diagnosed whether those who were previously undiagnosed detected diabetes survey screening, had elevated FPG, HbA1c or both. developed prediction equations for estimating probability that a person without at specific level HbA1c,...
Abstract Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered surrogate marker of insulin resistance (IR); in addition, it estimated to be better expression IR than widely used tools. Few and heterogeneous data are available on the relationship between this mortality risk non-Asian populations. Therefore, we predictive role baseline TyG incidence all-cause cardiovascular (CV) large sample general population. Moreover, consideration well-recognized serum uric...
Increased platelet thromboxane (TX)A2 production has been described in type IIa hypercholesterolemia. To verify the relevance of these capacity-related measurements to actual rate TXA2 biosynthesis vivo, we studied urinary excretion its major enzymatic metabolites 46 patients with hypercholesterolemia and 20 age-matched controls.Urinary 11-dehydro-TXB2 2,3-dinor-TXB2 were measured by previously validated radioimmunoassays. The was significantly (p less than 0.001) higher (68.7 +/- 35.1...
Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating clinical and genetic diagnosis named LIPIGEN (LIpid TransPort Disorders GEnetic Network). Observational, multicenter, retrospective prospective study involving about 40 centers....
Objective: To assess the prognostic cut-off values of serum uric acid (SUA) in predicting fatal and morbid heart failure a large Italian cohort frame Working Group on Uric Acid Cardiovascular Risk Society Hypertension. Methods: The URic Right for heArt Health (URRAH) study is nationwide, multicentre, involving data individuals aged 18–95 years, recruited community basis from all regions Italy under patronage Hypertension with mean follow-up period 128 ± 65 months. Incident was defined...
Objective: Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on role of diuretic-related are still scanty. The present study was designed to collect information events. Methods: URic acid Right for heArt Health (URRAH) is a nationwide, multicentre, observational cohort involving individuals recruited from all Italy territory under patronage Italian Society Hypertension with an average follow-up period 122.3 ± 66.9 months. Patients...
Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on mechanisms underlying excess cardiovascular mortality associated both hyperuricemia lead to risk stratification. Our main goal was study relationships between serum measures (namely estimated GFR [eGFR] albuminuria) large cohort individuals at from URic Right for...
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some explored the role of creatinine (sCr)-normalized (SUA/sCr) ratio in different settings. Previously, URRAH (URic Right for heArt Health) Study has identified cut-off value this index to predict CV mortality at 5.35 Units. Therefore, given no SUA/sCr threshold risk been patients with diabetes, we aimed assess...
Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, exact level at which risk begins to rise is unclear. The Working Group Uric Acid Cardiovascular Risk of Italian Society Hypertension has conceived a protocol aimed searching for prognostic cutoff value in predicting events large regional-based cohort.
Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway IR, while IR is a known predictor for development of hyperuricemia. The triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker IR. This research aimed investigate interaction between glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk large...
Serum uric acid (SUA) has been depicted as a contributory causal factor in metabolic syndrome (MS), which turn, portends unfavourable prognosis.We assessed the prognostic role of SUA patients with and without MS.We used data from multicentre Uric Acid Right for Heart Health study considered cardiovascular mortality (CVM) death due to fatal myocardial infarction, stroke, sudden cardiac death, or heart failure.A total 9589 subjects (median age 58.5 years, 45% males) were included analysis,...
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in presence of normal high TG has never been investigated. We included 8124 patients from URic Right for heArt Health (URRAH) study cohort who were followed over 20 years had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) (CVM) explored by Kaplan-Meier estimator Cox...
Context: Lipase maturation factor 1 (LMF1) gene is a novel candidate in severe hypertriglyceridemia. Lmf1 involved the of lipoprotein lipase (LPL) and hepatic endoplasmic reticulum. To date only one patient with hypertriglyceridemia related disorders was found to be homozygous for nonsense mutation LMF1 (Y439X). Objective: The objective study investigate hypertriglyceridemic patients whom mutations LPL, APOC2, APOA5 genes had been excluded. Results: resequencing led discovery recurrent...