Elisa Russo
A5067659374- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Case Reports on Hematomas
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Acute Kidney Injury Research
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Muscle and Compartmental Disorders
- Diabetes and associated disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 and healthcare impacts
- Blood Pressure and Hypertension Studies
- Vasculitis and related conditions
- Sodium Intake and Health
- Receptor Mechanisms and Signaling
- Inflammasome and immune disorders
- Potassium and Related Disorders
- Infective Endocarditis Diagnosis and Management
- Virus-based gene therapy research
- CAR-T cell therapy research
University of Genoa
2020-2025
Ospedale Policlinico San Martino
2020-2025
Jackson and Tull (United States)
2023
Centro Studi Luca d’Agliano
2022
Policlinico Universitario di Catania
2017
University of Catania
2017
Abstract Background The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high. Nevertheless, data are lacking about the determinants acute injury (AKI) and combined effect chronic disease (CKD) AKI in COVID-19 patients. Methods We collected on patient demographics, comorbidities, medications, vital signs, baseline laboratory test results in-hospital treatment patients with consecutively admitted our Institution. Chronic was defined as eGFR < 60 mL/min...
Abstract Purpose Recently, a novel index [the triglyceride-glucose (TyG) index]) was considered surrogate marker of insulin resistance (IR); in addition, it estimated to be better expression IR than widely used tools. Few and heterogeneous data are available on the relationship between this mortality risk non-Asian populations. Therefore, we predictive role baseline TyG incidence all-cause cardiovascular (CV) large sample general population. Moreover, consideration well-recognized serum uric...
Despite longstanding epidemiologic data on the association between increased serum triglycerides and cardiovascular events, exact level at which risk begins to rise is unclear. The Working Group Uric Acid Cardiovascular Risk of Italian Society Hypertension has conceived a protocol aimed searching for prognostic cutoff value in predicting events large regional-based cohort.
Several studies have detected a direct association between serum uric acid (SUA) and cardiovascular (CV) risk. In consideration that SUA largely depends on kidney function, some explored the role of creatinine (sCr)-normalized (SUA/sCr) ratio in different settings. Previously, URRAH (URic Right for heArt Health) Study has identified cut-off value this index to predict CV mortality at 5.35 Units. Therefore, given no SUA/sCr threshold risk been patients with diabetes, we aimed assess...
Hyperuricemia is commonly observed in patients with chronic kidney disease (CKD). However, a better understanding of the relationship among uric acid (UA) values, glomerular filtration rate (GFR) and albuminuria may shed light on mechanisms underlying excess cardiovascular mortality associated both hyperuricemia lead to risk stratification. Our main goal was study relationships between serum measures (namely estimated GFR [eGFR] albuminuria) large cohort individuals at from URic Right for...
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in presence of normal high TG has never been investigated. We included 8124 patients from URic Right for heArt Health (URRAH) study cohort who were followed over 20 years had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) (CVM) explored by Kaplan-Meier estimator Cox...
To evaluate the impact of Coronavirus Disease-19 (COVID-19) pandemic on epidemiology acute kidney injury (AKI) in hospitalized patients, we performed a retrospective cohort study comparing data patients from January 2016 to December 2019 (pre-COVID-19 period) and 2020 (COVID-19 period, including both severe respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative positive patients). AKI was classified by evaluating kinetics creatinine levels. A total 51,681 during pre-COVID-19 period 10,062...
The mechanisms by which hyperuricemia induces vascular dysfunction and contributes to cardiovascular disease are still debated. Phenotypic transition is a property of smooth muscle cells (VSMCs) involved in organ damage. aim this study was investigate the effects uric acid (UA) on changes VSMC cytoskeleton, cell migration signals these processes. MOVAS, mouse line, incubated with 6, 9 12 mg/dL UA, angiotensin receptor blockers (ARBs), proteasome MEK-inhibitors. Migration assessed...
Anti-aging therapy is the latest frontier in world of medical science, especially for widespread diseases such as chronic kidney disease (CKD). Both renal aging and CKD are characterized by increased cellular senescence, inflammation oxidative stress. A variety signalling mechanisms involved these processes, which provide new potential targets therapeutic strategies aimed at counteracting onset progression CKD. At same time, sodium-glucose co-transporter 2 inhibitors (SGLT2is) continuously...
Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway IR, while IR is a known predictor for development of hyperuricemia. The triglyceride (TG) high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker IR. This research aimed investigate interaction between glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk large...
Abstract Monoclonal Gammopathy of Renal Significance (MGRS) is a group rare disorders in which monoclonal proteins cause kidney damage. Due to its rarity, ongoing research vital refine diagnostics, enhance treatment, and improve outcomes. This retrospective study analyzed 34 patients with renal biopsy-proven MGRS-defining lesions. Patients were divided into two subgroups: kidney-limited AL amyloidosis (MGRS-A, 44%, n = 15) other MGRS (MGRS-NA, 56%, 19). Key outcomes included progression-free...
Abstract Acute Kidney Injury (AKI) is a common condition with significant impact on morbidity, mortality, and healthcare costs. This study explores the epidemiology of AKI, highlighting key factors outcomes. In retrospective we evaluated patients admitted to hospital from 2016 2019, excluding those pre-existing chronic kidney disease (CKD) stages 4–5. Data were extracted databases, AKI defined by changes in serum creatinine (sCr) according KDIGO criteria. Additionally, was classified as “de...
Background: Serum uric acid predicts the onset and progression of kidney disease, occurrence cardiovascular all-cause mortality. Nevertheless, it is unclear which appropriate definition hyperuricemia in presence chronic disease (CKD). Our goal was to study independent impact CKD on Methods: We retrospectively investigated 21,963 patients from URRAH database. Hyperuricemia defined basis outcome specific cut-offs separately identified by ROC curves according eGFR strata. The primary endpoints...
A relationship between serum uric acid (SUA) and cardiovascular (CV) events has been documented in the Uric Acid Right for Heart Health (URRAH) study.Aimof this study was to investigate association SUA left ventricular mass index (LVMI) whether LVMI or their combination may predict incidence of CV death.MethodsSubjects with echocardiographic measurement included URRAH (n=10733) were part analysis. LV hypertrophy (LVH) defined as > 95 g/m2 women 115 men.ResultsA significant observed multiple...
BACKGROUND: Uric acid has long been considered responsible for a single specific disease, namely gout. In recent years, novel knowledge emerged linking serum uric with variety of conditions and related risk factors, from hypertension, metabolic syndrome, type 2 diabetes, to fatal/nonfatal cardiovascular diseases all-cause death, the underlying mechanisms involving disrupted neurohormonal signaling as well oxidative stress inflammation. Importantly, cut-off value that predicts incident events...