Chiara Russo
A5104142773- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Infant Development and Preterm Care
- Antimicrobial Resistance in Staphylococcus
- Neonatal Respiratory Health Research
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Diabetes and associated disorders
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Neutropenia and Cancer Infections
- Central Venous Catheters and Hemodialysis
- Vaccine Coverage and Hesitancy
- Neonatal and Maternal Infections
Centre Léon Bérard
2025
Université Claude Bernard Lyon 1
2025
University of Genoa
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2025
Istituto Giannina Gaslini
2011-2025
Ospedale Policlinico San Martino
2020-2024
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2020
University of Stuttgart
2006
Severely immunocompromised patients are at risk for prolonged or relapsed Coronavirus Disease 2019 (COVID-19), leading to increased morbidity and mortality. We aimed evaluate efficacy safety of combination treatment in COVID-19 patients.We included all with prolonged/relapsed treated therapy 2 antivirals (remdesivir plus nirmatrelvir/ritonavir, molnupiravir case renal failure) plus, if available, anti-spike monoclonal antibodies (mAbs), between February October 2022. The main outcomes were...
Introduction Coronavirus disease 2019 (COVID-19) can lead to respiratory failure due severe immune response. Treatment targeting this response might be beneficial but there is limited evidence on its efficacy. The aim of study was determine if early treatment patients with COVID-19 pneumonia tocilizumab and/or steroids associated better outcome. Methods This observational single-center included who were not intubated and received either standard care (SOC, controls) or SOC plus (within 3...
Abstract Background The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high. Nevertheless, data are lacking about the determinants acute injury (AKI) and combined effect chronic disease (CKD) AKI in COVID-19 patients. Methods We collected on patient demographics, comorbidities, medications, vital signs, baseline laboratory test results in-hospital treatment patients with consecutively admitted our Institution. Chronic was defined as eGFR < 60 mL/min...
Summary Outcome of early treatment COVID‐19 with antivirals or anti‐spike monoclonal antibodies (MABs) in patients haematological malignancies (HM) is unknown. A retrospective study HM treated for mild/moderate between March 2021 and July 2022 was performed. The main composite end‐point failure (severe COVID‐19‐related death). We included 328 consecutive who received MABs ( n = 120, 37%; sotrovimab, 73) 208, 63%; nirmatrelvir/ritonavir, 116) over a median two days after symptoms started; 111...
Isavuconazole is first-line treatment of invasive aspergillosis. Therapeutic drug monitoring (TDM) deemed not necessary, since most patients reached therapeutic levels (>1 mg/L) in large studies. Low were reported some critically ill admitted to the ICU. The aim was compare isavuconazole between and non-critically patients.
In last years the diffusion of carbapenem resistance in Gram-negative bacteria (CR-GNB) is increasing worldwide, mainly due to expression carbapenemases. Cefiderocol has molecular characteristics that ideally confers activity against all CR-GNB, but resistant strains have already been identified. We describe cefiderocol susceptibility profile among multi-drug isolated from pediatric patients.
Phosphatidylinositol-4-kinase-IIIbeta (PI4KIIIbeta) is activated at the Golgi compartment by PKD-mediated phosphorylation. Subsequent mechanisms responsible for continuous PtdIns(4)P production membranes and potential interaction partners of PI4KIIIbeta are unknown. Here we identify phosphoserine/-threonine binding 14-3-3 proteins as novel regulators activity downstream this The PI4KIIIbeta-14-3-3 interaction, evident from GST pulldowns, co-immunoprecipitations bimolecular fluorescence...
Background Wolfram Syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by Diabetes Insipidus, Mellitus, Optic Atrophy, and Deafness identified the acronym "DIDMOAD". The WS gene, WFS1, encodes a transmembrane protein called Wolframin, which recent evidence suggests may serve as novel endoplasmic reticulum calcium channel in pancreatic β-cells neurons. rare disease, with estimated prevalence of 1/550.000 children, carrier frequency 1/354. aim our study was to...
An unexpected high prevalence of enterococcal bloodstream infection (BSI) has been observed in critically ill patients with COVID-19 the intensive care unit (ICU).The primary objective was to describe characteristics ICU-acquired BSI COVID-19. A secondary exploratorily assess predictors 30-day mortality BSI.During study period, 223 were admitted COVID-19-dedicated ICUs our centre. Overall, 51 episodes BSI, occurring 43 patients, registered. 29 (56.9%) and 22 (43.1%) caused by Enterococcus...
Background/Objectives: Meropenem is a broad-spectrum antibiotic essential for treating resistant Gram-negative infections in pediatric patients. Current dosing recommendations may not consistently achieve optimal pharmacokinetic (PK) targets, especially critically ill children. Methods: We conducted retrospective cohort study at IRCCS Istituto Giannina Gaslini, analyzing 97 plasma levels from 86 patients (<18 years) hospitalized between January 2020 and December 2023 the neonatal...
Background: Urinary tract infections (UTIs) are among the most common bacterial in children, and antibiotic susceptibility youngest patients remains poorly understood. This study aimed to describe distribution of uropathogens their susceptibility, focusing on oral formulations. Methods: Data from first microbiological isolation, between January 2007 December 2023, at Istituto Gaslini, young infants (aged <6 months), were analyzed. Results: We isolated 2473 infants’ pathogen, with a median...
To the Editors: In June 2024, Patel et al updated guideline for managing Clostridioides difficile infection (CDI) in pediatric cancer and hematopoietic cell transplantation patients.1 We recently observed a severe CDI 13-year-old girl with acute lymphoblastic leukemia who developed marked oral gastrointestinal mucositis following high-dose methotrexate. The recommended vancomycin or fidaxomicin CDI. However, her profound precluded drug swallowing, extensive hindered medication delivery via...
The diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is challenging, and the role Aspergillus-PCR bronchoalveolar lavage (BAL) unknown.This study evaluated diagnostic accuracy BAL IPA three different cohorts: ICU-admitted with COVID-19, without COVID-19 immunocompromised patients.All stored available samples collected from patient groups were tested (AsperGenius® ). was diagnosed according to appropriate criteria for each group.We included 111 101...
Treatment of severe infections due to Acinetobacter baumannii with difficult-to-treat resistance (DTR-AB), which exhibits all β-lactams, β-lactam/β-lactamases inhibitor combinations, and fluoroquinolones, remains a challenge for clinicians.The present perspective provides personal view on both current future agents the treatment DTR-AB infections.We currently are in transition era infections, where past 20 years, polymyxin-based regimens have become most used approach (although possibly...
pneumonia (PJP) has high mortality rates in immunocompromised children, even though routine prophylaxis decreased incidence. The aim of this case series is to present the radiological and clinical pathway PJP a pediatric population.
Comprehensive Geriatric Assessment (CGA), the gold standard for detecting frailty in elderly cancer patients, is time-consuming and hard to apply routine clinical practice. Here we compared performance of two screening tools frailty, G8 SAOP2 their accuracy identifying vulnerable patients.We tested 282 patients aged 65 or older with a diagnosis solid candidate undergo surgical, medical and/or radiotherapy treatment. CGA, including functional cognitive status, depression, nutrition,...
Abstract Introduction Coronavirus disease 2019 (COVID-19) can lead to respiratory failure due severe immune response. Treatment targeting this response might be beneficial but there is limited evidence on its efficacy. The aim of study was determine if early treatment patients with COVID-19 pneumonia tocilizumab and/or steroids associated better outcome. Methods This observational single-center included who were not intubated and received either standard care (SOC, controls) or SOC plus...
Background Candidemia is associated with a heavy burden of morbidity and mortality in hospitalized patients. The availability blood culture results could require up to 48–72 h after draw; thus, early treatment decisions are made the absence definite diagnosis.
Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, retrospective study aimed to investigate clinical characteristics outcomes vs. non-vaccinated patients, both hospitalised infection 3 major hospitals Northern Italy. Data collection was retrospective, paper electronic medical records adult...