A5103049833- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Protein Kinase Regulation and GTPase Signaling
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Cellular transport and secretion
- Health, Medicine and Society
- Antibiotic Use and Resistance
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Shoulder Injury and Treatment
- Stroke Rehabilitation and Recovery
- Coronary Interventions and Diagnostics
- PARP inhibition in cancer therapy
- Cancer Risks and Factors
- Exercise and Physiological Responses
- Antifungal resistance and susceptibility
- Signaling Pathways in Disease
- Balance, Gait, and Falls Prevention
- Occupational and environmental lung diseases
- Healthcare cost, quality, practices
Centre Léon Bérard
2018-2023
Ospedale Policlinico San Martino
2013-2022
University of Chieti-Pescara
2015-2021
Centre de Recherche en Cancérologie de Lyon
2021
Université Claude Bernard Lyon 1
2018-2020
Fondazione Roma
2017
Istituto Giannina Gaslini
2001-2014
Labor (Italy)
2007
University of Stuttgart
2007
The COVID-19 pandemic poses a barrier to equal and evidence-based management of cancer in older adults. International Society Geriatric Oncology (SIOG) formed panel experts develop consensus recommendations on the implications several aspects care this age group including geriatric assessment (GA), surgery, radiotherapy, systemic treatment, palliative research.Age diagnosis are significant predictors adverse outcomes infection. In setting, GA is particularly valuable drive decision-making....
The Dbl family guanine nucleotide exchange factors (GEFs) contain a region of sequence similarity consisting catalytic homology (DH) domain in tandem with pleckstrin (PH) domain. PH domains are involved the regulated targeting signaling molecules to plasma membranes by protein-protein and/or protein-lipid interactions. Here we show that binding phosphatidylinositol 4,5-bisphosphate and 3,4,5-triphosphate results inhibition GEF activity on Rho GTPase Cdc42. Phosphatidylinositol significantly...
Dbl is the prototype of a large family GDP-GTP exchange factors for small GTPases Rho family. In vitro, known to activate and Cdc42 induce transformed phenotype. specifically expressed in brain gonads, but its vivo functions are largely unknown. To assess role neurogenesis gametogenesis, targeted deletion murine gene was accomplished embryonic stem cells. Dbl-null mice viable did not show either decreased reproductive performances or obvious neurological defects. Histological analysis mutant...
The objective of this study was to compare the clinical outcomes patients receiving a short course (SC) vs prolonged (PC) antifungal therapy for uncomplicated Candida bloodstream infections (BSIs).All episodes BSI from September 1, 2018, August 31, 2020, were reviewed. We compared primary (all-cause 90-day mortality) and secondary end points (1-year recurrent all-cause 1-year among who underwent SC (5-11 days) or PC (12-24 using propensity score analysis with inverse probability treatment...
AbstractRho family GTPases play important roles in the regulation of intracellular signals induced by activated heterotrimeric G proteins α12/13 family. The subunits activate Rho through direct binding to a group guanine nucleotide exchange factors (GEFs) characterized presence protein signaling-like (RGL) domain. GEF proto-Dbl, that does not contain RGL domain, was also found link Gα12/13 Rho. We have explored effects Gα13 and Gα13-associated protein-coupled receptor (GPCR) agonists on...
Background The cause of heel pain among soccer players is multifactorial and related to repetitive microtrauma due impact forces involving technical moves, but also the playground, exercise mode, recovery time, climatic conditions footwear used. Aim To investigate aetiology plantar with objective proposing an example guidelines for treatment. Methods We investigated prevalence characteristics inferior 1473 professional, semiprofessional amateur players. All evaluated subjects were submitted...
By 6 months following a stroke, approximately 65% of stroke survivors cannot incorporate into daily activities, resulting completely dependent. The aim this study is to assess the overall outcome in psychological and physical well-being, increase residual abilities, reintegration social inclusion for people with chronic disabilities from after home rehabilitation.We assessed functional group 600 patients disability related several pathological conditions undergoing rehabilitation therapy...
The objective of this study is to assess the physical activity interest and preferences cancer patients aged over 70 years during oncological treatments explore how demographic characteristics may modulate preferences.From April May 2018, cross-sectional collected data from self-administered questionnaire regarding in receiving a regional centre.A total 144 completed questionnaire. Two thirds (n = 95) showed participating dedicated programme oncologic treatments. Patients preferred exercise...
Aging is a well-recognized risk factor for the development of cancer. The incidence new cancer diagnoses has increased globally given rising senior population. Many hypotheses this have been postulated over decades, including genetic and epigenetic mutations concept immunosenescence. optimal treatment strategies population with are unclear. Older patients traditionally under-represented in clinical trials developed to set standard care, leading undertreatment or toxicity. With background, it...
Abstract Moving from the first COVID–19 pandemic to chronic phase of COVID–19, more than 50 long–term detrimental effects have been recognized in so–called long syndrome. The exact mechanisms underlying exercise capacity reduction and functional limitations are unknown, however, rehabilitation could play a pivotal role. aim this study was evaluate whether combination aerobic resistance training performed same session for 8 weeks be well–tolerated effective patients with reduced [(<85%...