Guıdo Grassı
A5031410763- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Cardiovascular Syncope and Autonomic Disorders
- Heart rate and cardiovascular health
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- Alcohol Consumption and Health Effects
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Cardiac Health and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience of respiration and sleep
- Pharmacology and Obesity Treatment
- Obstructive Sleep Apnea Research
University of Milano-Bicocca
2016-2025
Medica (Italy)
1986-2024
Azienda Ospedaliera San Gerardo
2009-2023
European Society of Hypertension
2019-2023
Helmholtz Zentrum München
2023
Center for Environmental Health
2023
University Medical Center Hamburg-Eppendorf
2023
German Center for Diabetes Research
2023
University Medical Center of the Johannes Gutenberg University Mainz
2023
German Cancer Research Center
2023
The ESC/ESH Guidelines represent the views of ESC and ESH were produced after careful consideration scientific medical knowledge evidence available at time their dating.The are not responsible in event any contradiction, discrepancy, and/or ambiguity between other official
Mancia, Giuseppe; De Backer, Guy; Dominiczak, Anna; Cifkova, Renata; Fagard, Robert; Germano, Grassi, Guido; Heagerty, Anthony M; Kjeldsen, Sverre E; Laurent, Stephane; Narkiewicz, Krzysztof; Ruilope, Luis; Rynkiewicz, Andrzej; Schmieder, Roland Boudier, Harry AJ Struijker; Zanchetti, Alberto Authors/Task Force Members: Co-Chairperson (Italy) (Belgium) (UK) (Czech Republic) (Norway) (France) (Poland) (Spain) (Germany) (Netherlands) Author Information
For several years the European Society of Hypertension (ESH) and Cardiology (ESC) decided not to produce their own guidelines on diagnosis treatment hypertension but endorse issued by World Health Organization (WHO) International (ISH)1,2 with some adaptation reflect situation in Europe. However, 2003 decision was taken publish ESH/ESC specific guidelines3 based fact that, because WHO/ISH Guidelines address countries widely varying extent health care availability economic resource, they...
Mancia, Giuseppe; De Backer, Guy; Dominiczak, Anna; Cifkova, Renata; Fagard, Robert; Germano, Grassi, Guido; Heagerty, Anthony M; Kjeldsen, Sverre E; Laurent, Stephane; Narkiewicz, Krzysztof; Ruilope, Luis; Rynkiewicz, Andrzej; Schmieder, Roland Boudier, Harry AJ Struijker; Zanchetti, Alberto Authors/Task Force Members: Co-Chairperson (Italy) (Belgium) (UK) (Czech Republic) (Norway) (France) (Poland) (Spain) (Germany) (Netherlands) Author Information
Abbreviations ACE: angiotensin-converting enzyme; BP: blood pressure; DBP: diastolic eGFR: estimated glomerular filtration rate; ESC: European Society of Cardiology; ESH: Hypertension; ET: endothelin; IMT: carotid intima-media thickness; JNC: Joint National Committee; LVH: left ventricular hypertrophy; LVM: mass; PDE-5: phosphodiesterase-5; PPAR-γ: peroxisome proliferators-activated receptor-γ; PWV: pulse wave velocity; SBP: systolic WHO: World Health Organization. Introduction In the 2...
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering...
Background— Studies in hypertensive patients suggest that ambulatory blood pressure (BP) is prognostically superior to office BP. Much less information available the general population, however. Obtaining this was purpose of Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. Methods and Results— Office, home, 24-hour BP values were obtained 2051 subjects between 25 74 years age who representative population Monza (Milan, Italy). Subjects followed up for an average 131 months,...
Abstract Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) estimate 10-year fatal non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40–69 years Europe. Methods results We derived models using individual-participant data from 45 cohorts 13 countries (677 684 individuals, 30 121 events). used sex-specific competing risk-adjusted models, including age, smoking status, systolic blood pressure,...
ACEangiotensin-converting enzymeBPblood pressureDBPdiastolic blood pressureeGFRestimated glomerular filtration rateESCEuropean Society of CardiologyESHEuropean HypertensionETendothelinIM...
In the Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study, office, home, and ambulatory blood pressure (BP) values were measured contemporaneously between 1990 1993 in a large population sample (n=2051). Cardiovascular (CV) non-CV death certificates collected over next 148 months, which allowed us to assess prognostic value of selective combined elevation these 3 BPs long follow-up. There 69 CV 233 all-cause deaths. Compared with subjects normal office 24-hour BP, hazard ratio...
Human obesity is characterized by profound alterations in the hemodynamic and metabolic states. Whether these involve sympathetic drive controversial. In 10 young obese subjects (body mass index, 40.5 +/- 1.2 kg/m2, mean SEM) with normal blood pressure 8 age-matched lean normotensive control subjects, we measured beat-to-beat arterial (Finapres technique), heart rate (electrocardiogram), postganglionic muscle nerve activity (microneurography at peroneal nerve), venous plasma norepinephrine...
Abstract —Studies performed in experimental animals and humans have documented that high blood pressure markedly impairs baroreceptor control of heart rate. Whether a similar impairment also characterizes sympathetic activity modulating peripheral vasomotor tone is still unknown. In 28 untreated essential hypertensive subjects [14 moderate 14 more severe degree, age 51.6±2.4 52.6±2.1 years (mean±SEM)] 13 secondary hypertensives (renovascular or pheochromocytoma, 50.1±4.6 years), we measured...
Blood pressure was monitored by a continuous intra-arterial recording in 46 subjects to investigate whether the alarm reaction and blood heart rate increases that occur during cuff measurement made physician 1) attenuate when physician's visit is repeated several times 2) are less pronounced if nurse measures pressure. In 16 peak mean rises occurred early part of first (22.6 +/- 1.8 mm Hg 17.7 1.7 beats/min) were virtually identical those occurring three subsequent visits same throughout...
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
BACKGROUND The pressor and tachycardic effects of cigarette smoking are associated with an increase in plasma catecholamines, suggesting the dependence these on adrenergic stimulation. Whether stimulation occurs at a central or peripheral level whether reflex mechanisms involved is unknown. METHODS AND RESULTS In nine normotensive healthy subjects (age, 33.0 +/- 3.5 years, mean SEM), we measured blood pressure (Finapres device), heart rate (ECG), calf flow vascular resistance (venous...