Christian Delles
A5040449404- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Sodium Intake and Health
- Advanced Proteomics Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Cardiac Imaging and Diagnostics
- Renin-Angiotensin System Studies
- Metabolomics and Mass Spectrometry Studies
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Hemodynamic Monitoring and Therapy
- Renal and Vascular Pathologies
- Genetic Associations and Epidemiology
- Lipoproteins and Cardiovascular Health
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Thermoregulation and physiological responses
University of Glasgow
2016-2025
Queen Elizabeth University Hospital
2016-2025
University of Naples Federico II
2024
Charité - Universitätsmedizin Berlin
2000-2024
Theranostics (New Zealand)
2024
Glasgow Centre for Population Health
2024
NHS Greater Glasgow and Clyde
2019-2024
British Heart Foundation
2007-2022
University of Copenhagen
2022
Semmelweis University
2022
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici (Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luís Bronze (Portugal), John Chalmers (Australia), Tine De Backer (Belgium), Alejandro de la Sierra (Spain), Kyriakos Dimitriadis Dorota Drozdz (Poland), Béatrice Duly-Bouhanick (France), Brent M. Egan (USA), Serap Erdine Claudio Ferri (Italy), Slavomira Filipova (Slovak Republic), Anthony Heagerty (UK), Michael Hecht Olsen (Denmark), Dagmara Hering...
Because of its availability, ease collection, and correlation with physiology pathology, urine is an attractive source for clinical proteomics/peptidomics. However, the lack comparable data sets from large cohorts has greatly hindered development proteomics. Here, we report establishment a reproducible, high resolution method peptidome analysis naturally occurring human urinary peptides proteins, ranging 800 to 17,000 Da, using samples 3,600 individuals analyzed by capillary electrophoresis...
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
<h3>Objectives</h3> The interleukin-6 receptor (IL-6R) blocker tocilizumab (TCZ) reduces inflammatory disease activity in rheumatoid arthritis (RA) but elevates lipid concentrations some patients. We aimed to characterise the impact of IL-6R inhibition on established and novel risk factors active RA. <h3>Methods</h3> Randomised, multicentre, two-part, phase III trial (24-week double-blind, 80-week open-label), MEASURE, evaluated lipoprotein levels, high-density (HDL) particle composition,...
In the diagnosis of obstructive coronary artery disease (CAD), computed tomography (CT) is an accurate, noninvasive alternative to invasive angiography (ICA). However, comparative effectiveness CT and ICA in management CAD reduce frequency major adverse cardiovascular events uncertain.We conducted a pragmatic, randomized trial comparing with as initial diagnostic imaging strategies for guiding treatment patients stable chest pain who had intermediate pretest probability were referred at one...
Progressive CKD is generally detected at a late stage by sustained decline in eGFR and/or the presence of significant albuminuria. With aim early and improved risk stratification patients with CKD, we studied urinary peptides large cross-sectional multicenter cohort 1990 individuals, including 522 follow-up data, using proteome analysis. We validated that previously established multipeptide biomarker classifier performed significantly better detecting predicting progression than current...
Importance Pregnancy hypertension results in adverse cardiac remodeling and higher incidence of cardiovascular diseases later life. Objective To evaluate whether an intervention designed to achieve better blood pressure control the postnatal period is associated with lower than usual outpatient care during first 9 months postpartum. Design, Setting, Participants Randomized, open-label, blinded, end point trial set a single hospital UK. Eligible participants were aged 18 years or older,...
Abstract Background and Aims Visit-to-visit systolic blood pressure variability (BPV) is an important predictor of cardiovascular (CV) outcomes. The long-term effect a period (BP) control, but with differential BPV, uncertain. Morbidity mortality follow-up UK participants in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure-Lowering Arm has been extended for up to 21 years determine CV impact mean (SBP) control BPV during trial, amongst those allocated amlodipine- atenolol-based...
A limitation of proteomic methods with respect to their clinical applicability is the lack possibilities directly deduce amount a protein or peptide from particular mass spectrometry (MS) spectrum. For quantification chronic kidney disease (CKD)-specific urinary polypeptides in capillary electrophoresis coupled (CE-MS), we compared signal intensity calibration based on either creatinine stable isotope labeled synthetic marker analogues (absolute quantification) those ion counting using...
Urinary proteomics is emerging as a powerful non-invasive tool for diagnosis and monitoring of variety human diseases. We tested whether signatures urinary polypeptides can contribute to the existing biomarkers coronary artery disease (CAD). examined total 359 urine samples from 88 patients with severe CAD 282 controls. Spot was analyzed using capillary electrophoresis on-line coupled ESI-TOF-MS enabling characterization more than 1000 per sample. In first step "training set" biomarker...