A5013729622- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Urological Disorders and Treatments
- Knee injuries and reconstruction techniques
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Shoulder Injury and Treatment
- Birth, Development, and Health
- Cardiac Health and Mental Health
- Advanced MRI Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Chronic Kidney Disease and Diabetes
- Pharmaceutical studies and practices
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Education
- Coronary Interventions and Diagnostics
- Obesity and Health Practices
- Acute Myocardial Infarction Research
- Total Knee Arthroplasty Outcomes
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular and Diving-Related Complications
- Vitamin K Research Studies
University of Glasgow
2018-2025
National Health Service Scotland
2024
British Heart Foundation
2018-2023
Queen Elizabeth University Hospital
2022
Glasgow Royal Infirmary
2014-2015
Orthopaedic Research
2015
NHS Greater Glasgow and Clyde
2015
Canterbury District Health Board
2007
Canterbury Health Laboratories
2007
University of Otago
2007
Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with reduced ejection fraction (HFrEF). However, their effects on cardiac structure function HFrEF are uncertain.We designed a multicenter, randomized, double-blind, placebo-controlled trial (the SUGAR-DM-HF [Studies Empagliflozin Its Cardiovascular, Renal Metabolic Effects Patients With Diabetes Mellitus, or Prediabetes, Heart Failure]) to investigate empagliflozin...
Abstract Background and Aims To examine the decongestive effect of sodium-glucose cotransporter 2 inhibitor dapagliflozin compared to thiazide-like diuretic metolazone in patients hospitalized for heart failure resistant treatment with intravenous furosemide. Methods results A multi-centre, open-label, randomized, active-comparator trial. Patients were randomized 10 mg once daily or 5–10 a 3-day period, follow-up primary secondary endpoints until day 5 (96 h). The endpoint was effect,...
The epidemiology of peripartum cardiomyopathy (PPCM) in Europe is poorly understood and data on long-term outcomes are lacking. A retrospective, observational, population-level study validated cases PPCM Scotland from 1998 to 2017 was conducted.Women hospitalized with presumed de novo left ventricular systolic dysfunction around the time pregnancy no clear alternative cause were included. Each case matched 10 controls. Incidence risk factors identified. Morbidity mortality examined mothers...
Objectives : To assess the acute effects of nicotine-containing electronic cigarettes versus tobacco smoking on vascular and respiratory function circulating microparticles, particularly platelet microparticles (PMPs, biomarker haemostasis/thrombosis) endothelial (EMPs, function). Methods Heart rate (HR), blood pressure, reactive hyperaemia index (RHI, microvascular reactivity), augmentation (arterial stiffness) were assessed in 20 smokers immediately before after use smoking. The number was...
Patients with a reduced left ventricular ejection fraction (LVEF) following an acute myocardial infarction (MI) are at risk of progressive adverse cardiac remodelling that can lead to the development heart failure and death. The early addition sodium-glucose cotransporter 2 (SGLT2) inhibitor standard treatment may delay or prevent in these patients.
Patients with left ventricular (LV) systolic dysfunction after myocardial infarction are at a high risk of developing heart failure. The addition neprilysin inhibition to renin angiotensin system may result in greater attenuation adverse LV remodeling as increased levels substrates for vasodilatory, antihypertrophic, antifibrotic, and sympatholytic effects.We performed prospective, multicenter, randomized, double-blind, active-comparator trial comparing sacubitril/valsartan 97/103 mg twice...
Hypogonadism is associated with cardiovascular disease. However, the impact of hypogonadism during development unknown. Using hypospadias as a surrogate hypogonadism, we investigated whether vascular dysfunction and risk factor for disease.Our human study spanned molecular mechanistic to epidemiological investigations. Clinical phenotyping was performed in adolescents controls. Small subcutaneous arteries from penile skin boys undergoing repair controls were isolated functional studies...
UMOD (uromodulin) has been linked to hypertension through potential activation of Na
Background Vascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents, but associated with cancer therapy-related cardiac dysfunction (CTRCD) and hypertension. The timing, frequency magnitude of these toxicities poorly defined. objective this study is therefore to investigate the incidence, time course mechanisms VEGFI-associated CTRCD Methods Patients commencing VEGFI underwent blood pressure (BP) monitoring, echocardiography biomarker measurement at baseline...
Background Reliable non-invasive diagnosis of meniscal tears is difficult. Magnetic resonance imaging (MRI) often used but expensive and incidental findings are problematic. There a number physical examination tests for the that simple, cheap non-invasive. Objectives To determine diagnostic accuracy Thessaly test to if (alone or in combination with other tests) can obviate need further investigation by MRI arthroscopy patients suspected tear. Design Single-centre prospective study. Setting...
Abstract Objectives Studies have suggested phosphodiesterase 4 (PDE4) inhibition may be associated with weight loss and other cardiometabolic benefits. We evaluated the effect of PDE4 inhibitor apremilast on body composition, glucose homeostasis, lipid profiles vascular function in psoriatic disease whether change correlated therapeutic response. Methods conducted a prospective, open-label study (Immune Metabolic Associations Psoriatic Arthritis) adults receiving 30 mg as part routine care...
Abstract Aims Subcutaneous (SC) furosemide has potential advantages over intravenous (IV) by enabling self-administration or administration a lay caregiver, such as facilitating early discharge, preventing hospitalizations, and in palliative care. A high-concentration, pH-neutral formulation been developed for SC via small patch infusor pump. We aimed to compare the bioavailability, pharmacokinetic (PK), pharmacodynamic (PD) profiles of new with conventional IV describe first use bespoke...
Mallet finger injuries are usually successfully treated non-operatively with a splint. Most patients reviewed at least twice in clinic after the initial presentation A&E. A new protocol promoting "self-care" was introduced our institution. Patients were provided structured verbal and written information, given access to telephone helpline. prospective electronic patient record used identify all who presented emergency department mallet minimum six month follow-up. satisfaction reported...
Health-related quality of life (HRQoL) is impaired in patients with stable angina but often present other forms chest pain. The aim this study was to compare the pre-diagnostic HRQoL suspected coronary artery disease (CAD) according type, gender, and presence obstructive CAD. From pilot for European DISCHARGE trial, we analysed data from 24 sites including 1263 (45.9% women, 61.1 ± 11.3 years) who were clinically referred invasive angiography (ICA; 617 patients) or computed tomography (CTA;...
Introduction Angina with no obstructive coronary artery disease (ANOCA) is a common syndrome unmet clinical needs. Microvascular and vasospastic angina are relevant but may not be diagnosed without measuring vascular function. The relationship between cardiovascular magnetic resonance (CMR)-derived myocardial blood flow (MBF) reference invasive function tests uncertain. We hypothesise that multiparametric CMR assessment will clinically useful in the ANOCA diagnostic pathway. Methods/analysis...
Abstract BACKGROUND Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the uromodulin gene (UMOD) affecting excretion and blood pressure (BP). Uromodulin is almost exclusively expressed in thick ascending limb (TAL) of loop Henle its effect on BP appears to be mediated via TAL sodium transporter, NKCC2. Loop-diuretics block NKCC2 but are not commonly used hypertension management. Volume overload one primary drivers for uncontrolled hypertension, so...
Introduction Questionnaires are used commonly to assess functional outcome and satisfaction in surgical patients. Although these have the past been administered through written forms, there is increasing interest use of new technology improve efficiency collection. The aim this study was availability internet access for a group orthopaedic patients acceptability online survey completion. Methods A total 497 attending outpatient clinics were surveyed their preferred means completing follow-up...
Background Flow-mediated dilation (FMD) is a non-invasive imaging modality used to measure endothelial function but has significant intra- and inter-observer variability. The use of semi-automated FMD devices could overcome this limitation. We assessed the reproducibility same-day measurements by investigators who received basic training on correct device. Methods Forty-three healthy volunteers had two brachial artery performed 20 minutes apart using UNEX EF 38G device, automated outputs...
Abstract Aims In patients at high risk of heart failure following myocardial infarction (MI) as a result residual left ventricular systolic dysfunction (LVSD), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan may in greater attenuation adverse (LV) remodelling than renin aldosterone system inhibition alone, due to increased levels substrates for with vasodilatory, anti‐hypertrophic, anti‐fibrotic, and sympatholytic effects. Methods We designed randomized, double‐blinded,...
Background Renal transplant recipients (RTRs) exhibit increased vascular stiffness and calcification; these parameters are associated with cardiovascular risk. Activity of endogenous calcification inhibitors such as matrix gla protein (MGP) is dependent on vitamin K. RTRs commonly have subclinical K deficiency. The Vitamin in kidney Transplant Organ Recipients: Investigating vEssel Stiffness (ViKTORIES) study assesses whether supplementation reduces a diverse population RTR. Methods analysis...