Sandosh Padmanabhan
A5016286778- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Sodium Intake and Health
- Renin-Angiotensin System Studies
- Cardiac electrophysiology and arrhythmias
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Bioinformatics and Genomic Networks
- Cardiac Health and Mental Health
- Cancer-related molecular mechanisms research
- Cardiomyopathy and Myosin Studies
- Renal function and acid-base balance
- Genetic Mapping and Diversity in Plants and Animals
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetics and Physical Performance
- Nutritional Studies and Diet
University of Glasgow
2016-2025
Queen Elizabeth University Hospital
2024-2025
British Heart Foundation
2015-2024
Radiance Technologies (United States)
2023
Vanderbilt University Medical Center
2023
RELX Group (Netherlands)
2023
RELX Group (United States)
2023
Jehangir Clinical development Centre
2022
University of Hawaiʻi at Mānoa
2021
Genomics (United Kingdom)
2016-2021
Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that most often caused by excessive sodium retention, and spironolactone would therefore be superior non-diuretic add-on drugs at lowering blood pressure.In this double-blind, placebo-controlled, crossover trial, we enrolled aged 18-79 years seated clinic systolic pressure 140 mm Hg or greater (or ≥135 diabetes) home (18 readings over 4 days) 130 greater, despite least 3 months...
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause unknown, there debate about whether it single disease entity what role ANCA plays in its pathogenesis. We investigated genetic basis.
Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of 2 randomized controlled primary prevention trials (ASCOT [Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm] and JUPITER [Justification for the Use Statins Prevention: An Intervention Trial Evaluating Rosuvastatin]), led a greater relative among subgroup at high genetic risk. Here, we aimed confirm this observation third trial. In addition, assessed...
Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis not fully understood. We investigated genetic biopsy-proven cases idiopathic white population.We performed independent genomewide association studies single-nucleotide polymorphisms (SNPs) patients with from three populations ancestry (75 French, 146 Dutch, and 335 British patients). The were compared racially matched control subjects; population stratification quality controls...
Alcohol consumption has been linked to over 200 diseases and is responsible for 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, example, ALDH2 ADH1B, are strongly associated with but have limited impact European populations where they found at low frequency. We performed a genome-wide association study (GWAS) self-reported 112 117 individuals UK Biobank (UKB) sample white British individuals. report significant associations 14 loci. These include...
Hypertension is a heritable and major contributor to the global burden of disease. The sum rare common genetic variants robustly identified so far explain only 1%–2% population variation in BP hypertension. This suggests existence more undiscovered variants. We conducted genome-wide association study 1,621 hypertensive cases 1,699 controls follow-up validation analyses 19,845 16,541 using an extreme case-control design. locus on chromosome 16 5′ region Uromodulin (UMOD; rs13333226, combined...
Demographic and family studies support the existence of a genetic contribution to pathogenesis IgA nephropathy, but results from association candidate genes are inconsistent. To systematically survey common variation in this disease, we performed genome-wide analysis cohort patients with nephropathy selected UK Glomerulonephritis DNA Bank. We used two groups controls: parents affected individuals previously genotyped, unaffected, ancestry-matched 1958 British Birth Cohort Blood Service....
There is great interest in widening the use of high-sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it not clear whether troponin T (cTnT) I (cTnI) are equivalent measures risk this setting. We aimed to compare contrast (1) association cTnT cTnI with CVD non-CVD outcomes, (2) their determinants a genome-wide study.High-sensitivity were measured serum from 19 501 individuals Generation Scotland Scottish Family Health Study....
In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess mechanisms underlying this superiority and pathogenesis hypertension.PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary secondary care sites in 314 patients with hypertension. Patients were given 12 weeks once daily treatment each placebo, 25-50 mg, bisoprolol 5-10 doxazosin 4-8 mg...
Abstract Hand grip strength is a widely used proxy of muscular fitness, marker frailty, and predictor range morbidities all-cause mortality. To investigate the genetic determinants variation in strength, we perform large-scale discovery analysis combined sample 195,180 individuals identify 16 loci associated with ( P <5 × 10 −8 ) analyses. A number these contain genes implicated structure function skeletal muscle fibres ACTG1 ), neuronal maintenance signal transduction PEX14, TGFA, SYT1...