A5020829872- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Renal function and acid-base balance
- Health Promotion and Cardiovascular Prevention
- Cardiac Health and Mental Health
- Anesthesia and Sedative Agents
- Pharmaceutical Practices and Patient Outcomes
- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Health Literacy and Information Accessibility
- DNA Repair Mechanisms
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Sex and Gender in Healthcare
- Eicosanoids and Hypertension Pharmacology
- Mobile Health and mHealth Applications
- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
University of Glasgow
2016-2019
Queen Mary University of London
2018
University of London
2018
William Harvey Research Institute
2018
Cancer Research UK Manchester Institute
2001
In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess mechanisms underlying this superiority and pathogenesis hypertension.PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary secondary care sites in 314 patients with hypertension. Patients were given 12 weeks once daily treatment each placebo, 25-50 mg, bisoprolol 5-10 doxazosin 4-8 mg...
We investigated demographic and clinical predictors of lower participation in bowel screening relative to breast cervical screening. Data linkage study routinely collected data from 430,591 women registered with general practices the Greater Glasgow & Clyde Health Board. Participation programmes was measured by attendance at or return a kit. 72.6% 159,993 invited attended screening, 80.7% 309,899 61.7% 180,408 completed Of 68,324 participate all three during period, 52.1% participated while...
Abstract Aims Ischaemic heart disease persists as the leading cause of death in both men and women most countries sex disparities, defined differences health outcomes their determinants, may be relevant. We examined disparities presenting characteristics, treatment all-cause mortality patients hospitalized with myocardial infarction (MI) or angina. Methods results conducted a cohort study all admitted MI angina (01 October 2013 to 30 June 2016) from secondary care acute coronary syndrome...
We previously showed that levels of chromosome damage induced by ionizing radiation were, on average, higher in G2and G0lymphocytes breast cancer patients than normal healthy controls, but there was no correlation between the results two assays. proposed enhanced sensitivity to G2or G0irradiation a marker low-penetrance predisposition cancer, and have recently demonstrated heritability families cases. now applied these assays with head neck cancers, for whom is epidemiological evidence...
Aims Therapy with angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) is a mainstay of treatment for heart failure (HF), diabetes mellitus (DM) chronic kidney disease (CKD). These agents have been associated development acute injury (AKI) during intercurrent illness. Risk factors AKI in patients prescribed ACEi/ARB therapy are not well described. Methods We captured the incidence commencing 2009–2015 using anonymised patient records. Hospital‐coded was...
Introduction There is an evidence gap about how to best treat patients with prior coronary artery bypass grafts (CABGs) presenting non-ST segment elevation acute syndromes (NSTE-ACS) because historically, these were excluded from pivotal randomised trials. We aim undertake a pilot trial of routine non-invasive management versus invasive in NSTE-ACS CABG and optimal medical therapy during clinical care. Our proof-of-concept study for feasibility, safety, potential efficacy health economic...
<h3>Background</h3> Lack of a robust, practical definition heart failure not only creates diagnostic uncertainty but limits the utility epidemiological estimates incidence, prevalence and prognosis on which health-care planning (both diagnosis management) depends. Moreover, because these uncertainties, research often focuses patients with whom there is high degree certainty about diagnosis, may be small fraction total disease burden. One important feature congestion class pharmaceutical...
IntroductionPopulation-based screening has been shown to reduce cancer specific mortality. Within Scotland, three national programmes exist: breast, cervical and bowel. Despite being a common preventable form of cancer, the uptake for bowel among women lags behind that breast cancer.
 Objectives ApproachSince benefits accrue with participation, it is important understand why differences in exist. In this study, data on aged 24-74 Greater Glasgow Clyde Health Board, invited take part one...