A5036302208- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Cardiovascular Health and Disease Prevention
- Pain Mechanisms and Treatments
- Cardiovascular and exercise physiology
- Pharmacological Effects and Toxicity Studies
- Hormonal Regulation and Hypertension
- Pharmaceutical Practices and Patient Outcomes
- Sodium Intake and Health
- Drug-Induced Hepatotoxicity and Protection
- Pain Management and Placebo Effect
- Birth, Development, and Health
- Musculoskeletal pain and rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Medication Adherence and Compliance
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Poisoning and overdose treatments
- Asthma and respiratory diseases
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Gestational Diabetes Research and Management
- Eosinophilic Esophagitis
University of Birmingham
2013-2025
Queen Elizabeth Hospital Birmingham
1998-2020
AstraZeneca (United States)
2019
William Harvey Research Institute
2018
Queen Mary University of London
2011-2018
Belfast Health and Social Care Trust
2017-2018
Therapeutics Clinical Research
2012-2018
Musgrave Park Hospital
2017-2018
University of London
2018
University of Ulster
2001-2017
<h2>Summary</h2><h3>Background</h3> Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place telemonitoring over alone is unclear. The TASMINH4 trial aimed to assess efficacy self-monitored blood pressure, with or without telemonitoring, for in primary care, compared usual care. <h3>Methods</h3> This study was a parallel randomised controlled done 142 general practices UK, included hypertensive patients older than 35...
In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess mechanisms underlying this superiority and pathogenesis hypertension.PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary secondary care sites in 314 patients with hypertension. Patients were given 12 weeks once daily treatment each placebo, 25-50 mg, bisoprolol 5-10 doxazosin 4-8 mg...
To determine whether, in normal pregnancies, there is evidence of oxidative stress that related to the lipid changes observed pregnancy.Longitudinal study healthy women having a pregnancy. Samples were obtained towards end each trimester and after 8 weeks postpartum.Seventeen during singleton pregnancy compared with 12 healthy, non-pregnant women.Oxidative was determined by measuring total antioxidant capacity (TAC), uric acid hydroperoxides (LHP). Lipid status evaluated high-density...
A diminished muscle anabolic response to protein nutrition may underpin age-associated loss. To determine how chronological and biological aging influence myofibrillar synthesis (MyoPS). Cross-sectional comparison. Clinical research facility. Ten older lean [OL: 71.7 ± 6 years; body mass index (BMI) ≤25 kg ⋅ m−2], 7 obese (OO: 69.1 2 BMI ≥30 m−2), 18 young (YL) individuals (25.5 4 m−2). Skeletal biopsies obtained during a primed-continuous infusion of l-[ring-13C6]-phenylalanine....
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Evidence to support initiation of pharmacologic treatment in low-risk patients with mild hypertension is inconclusive, previous trials underpowered demonstrate benefit. Clinical guidelines across the world are contradictory.
<b>Objective</b> To assess whether using intensive blood pressure targets leads to lower in a community population of people with prevalent cerebrovascular disease. <b>Design</b> Open label randomised controlled trial. <b>Setting</b> 99 general practices England, participants recruited 2009-11. <b>Participants</b> People history stroke or transient ischaemic attack whose systolic was 125 mm Hg above. <b>Interventions</b> Intensive target (<130 10 reduction from...
Serum cholesterol, triacylglycerols and low-density lipoprotein (LDL) subfractions were determined in 120 primagravid women during normal gestation (40 each trimester) 20 non-pregnant age-matched controls. LDL by PAGE, an score was calculated. The higher the score, smaller subfractions. objective of study to determine effects hyperlipidaemia, high oestrogen concentrations insulin resistance known exist pregnancy on subfraction formation. Pregnant had increased mean serum cholesterol...
The visceral afferent feedback hypothesis proposes that sensorimotor function is impaired by cortical inhibition associated with increased baroreceptor activation. This study the first to examine effects of naturally occurring variations in activity across cardiac cycle on cutaneous sensory detection thresholds. In each trial, an electrocutaneous stimulus was delivered index finger at one three intervals (0, 300, 600 ms) after R-wave electrocardiogram. Separate interleaving up-down...
Introduction Wolfram syndrome ( WFS1- Spectrum Disorder) is an ultra-rare monogenic form of progressive neurodegeneration and diabetes mellitus. In common with most rare diseases, there are no therapies to slow or stop disease progression. Sodium valproate, anticonvulsant neuroprotective properties, anticipated mediate its effect via alteration cell cycle kinetics, increases in p21 cip1 expression levels reduction apoptosis increase Wolframin protein expression. To date, have been...
A baroreflex mechanism may explain hypertensive hypoalgesia. At rest, arterial baroreceptors are stimulated during the systolic upstroke of pressure pulse wave. This study examined effects naturally occurring variations in baroreceptor activity cardiac cycle on an objective measure pain, nociceptive flexion reflex (NFR). Two interleaved up–down staircase procedures determined separate NFR thresholds systole and diastole 36 healthy, normotensive young adults. On odd‐numbered trials, sural...
Abstract Hypertension is characterized by cognitive deficits. As evidence for impaired psychomotor speed, including slower reaction times, mixed, we aimed to provide a detailed investigation of simple time in hypertension. Pre‐motor and motor times were measured across the cardiac cycle 30 hypertensives 29 normotensives determine effects phasic tonic blood pressure on performance. Auditory, visual, tactile tasks completed with stimuli presented 0, 300, 600 ms after R‐wave electrocardiogram....
Patients often have lower (white coat effect) or higher (masked ambulatory/home blood pressure readings compared with clinic measurements, resulting in misdiagnosis of hypertension. The present study assessed whether and patient characteristics from a single visit can accurately predict the difference between (the home-clinic difference). A linear regression model predicting was derived 2 data sets measuring automated (n=991) using candidate predictors identified literature review. validated...
Nonadherence to medication is present in at least 50% of patients with apparent treatment-resistant hypertension. We examined the factors associated nonadherence as detected by a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based urine antihypertensive drug assay.All test results, carried out for uncontrolled hypertension (BP persistently >140/90 mmHg) between January 2015 and December 2016 single toxicology laboratory were analysed. Drugs compared drugs prescribed. Patients...
Abstract The arterial baroreflex may mediate hypertensive hypoalgesia. Carotid baroreceptors can be artificially stimulated by neck suction and inhibited compression. Effects of brief compression on nociceptive responding pain were studied in 25 normotensive adults. sural nerve was electrocutaneously at threshold intensity during systole or diastole combined with suction, compression, no pressure. Nociceptive indexed electromyographic activity elicited the biceps femoris. Participants rated...
Systemic lupus erythematosus (SLE) patients suffer from excess cardiac deaths due to accelerated atherosclerosis. Endothelial dysfunction is a marker of early We tested the hypothesis that SLE have impaired endothelial function and assessed relationship between clinical outcome over subsequent five years. Thirty-six female were compared with 22 healthy age sex matched controls. dependent vasodilatation (EDD) was at brachial artery in response shear stress. Endotheliumindependent dilatation...