A5045695482- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Respiratory viral infections research
- Blood Pressure and Hypertension Studies
- Digital Mental Health Interventions
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Mobile Health and mHealth Applications
- Meta-analysis and systematic reviews
- Schizophrenia research and treatment
- Sleep and related disorders
- Sleep and Wakefulness Research
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Child and Adolescent Psychosocial and Emotional Development
- Medication Adherence and Compliance
- Chronic Disease Management Strategies
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health Research Topics
- Neuroscience of respiration and sleep
- Maternal Mental Health During Pregnancy and Postpartum
- Health disparities and outcomes
- Viral gastroenteritis research and epidemiology
University of Oxford
2016-2025
Soochow University
2025
Nuffield Health
2016-2024
Kowloon Hospital
2023
Primary Health Care
2019-2023
University of Birmingham
2017-2022
St Thomas' Hospital
2022
King's College London
2022
University of Southampton
2022
The Stables
2022
Abstract Background Our aim was to estimate provisional willingness receive a coronavirus 2019 (COVID-19) vaccine, identify predictive socio-demographic factors, and, principally, determine potential causes in order guide information provision. Methods A non-probability online survey conducted (24th September−17th October 2020) with 5,114 UK adults, quota sampled match the population for age, gender, ethnicity, income, and region. The Oxford COVID-19 vaccine hesitancy scale assessed intent...
BackgroundSleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads reduction paranoia and hallucinations.MethodsWe did single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with were randomly assigned (1:1) simple randomisation receive digital cognitive behavioural therapy (CBT) for or...
Meta-analysis has become a well-known method for synthesis of quantitative data from previously conducted research in applied health sciences. So far, meta-analysis been particularly useful evaluating and comparing therapies assessing causes disease. Consequently, the number software packages that can perform increased over years. Unfortunately, it take substantial amount time to get acquainted with some these programs most contain little or no interactive educational material. We set out...
To assess the clinical effectiveness of surgical stabilisation (spinal fusion) compared with intensive rehabilitation for patients chronic low back pain.
<b>Objectives</b> To examine the reporting characteristics and methodological details of randomised trials indexed in PubMed 2000 2006 assess whether quality has improved after publication Consolidated Standards Reporting Trials (CONSORT) Statement 2001. <b>Design</b> Comparison two cross sectional investigations. <b>Study sample</b> All primary reports December (n=519) (n=616), including parallel group, crossover, cluster, factorial, split body study designs. <b>Main outcome measures</b>...
Observational data suggest that the use of bilateral internal mammary arteries (BIMA) during coronary artery bypass graft surgery provides superior revascularization to a single (SIMA), but concerns about safety have prevented widespread BIMA. The Arterial Revascularisation Trial (ART) is randomized trial BIMA vs. SIMA, with primary outcome survival at 10 years. This paper reports mortality, morbidity, and resource 1 year. Coronary patients were enrolled in 28 hospitals seven countries....
<h2>Summary</h2><h3>Background</h3> Studies evaluating titration of antihypertensive medication using self-monitoring give contradictory findings and the precise place telemonitoring over alone is unclear. The TASMINH4 trial aimed to assess efficacy self-monitored blood pressure, with or without telemonitoring, for in primary care, compared usual care. <h3>Methods</h3> This study was a parallel randomised controlled done 142 general practices UK, included hypertensive patients older than 35...
<h3>Context</h3>In the absence of an effective vaccine, serogroup B Neisseria meningitidis (MenB) remains a major cause invasive disease in early childhood developed countries.<h3>Objective</h3>To determine immunogenicity and reactogenicity multicomponent MenB vaccine (4CMenB) routine infant vaccines when given either concomitantly or separately.<h3>Design, Setting, Participants</h3>Phase 2b, multicenter, open-label, parallel-group, randomized controlled study 1885 infants enrolled at age 2...
Salmonella enterica serovar Typhi (S Typhi) is responsible for an estimated 20 million infections and 200 000 deaths each year in resource poor regions of the world. Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic can be used from infancy but there no efficacy data leading candidate vaccine being considered widespread use. To address this knowledge gap, we assessed a Vi-tetanus toxoid using established human infection model S Typhi.
We assessed the effect of automated treatment adherence support delivered via mobile phone short message system (SMS) text messages on blood pressure.In this pragmatic, single-blind, 3-arm, randomized trial (SMS-Text Adherence Support [StAR]) undertaken in South Africa, patients treated for high pressure were randomly allocated a 1:1:1 ratio to information only, interactive SMS messaging, or usual care. The primary outcome was change systolic at 12 months from baseline measured with...
<h2>Summary</h2><h3>Background</h3> Azithromycin, an antibiotic with potential antiviral and anti-inflammatory properties, has been used to treat COVID-19, but evidence from community randomised trials is lacking. We aimed assess the effectiveness of azithromycin suspected COVID-19 among people in who had increased risk complications. <h3>Methods</h3> In this UK-based, primary care, open-label, multi-arm, adaptive platform trial interventions against at adverse clinical course (PRINCIPLE),...
Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses. It is not known whether polysaccharide-protein conjugated vaccines (PCV), although highly effective in infants, offer any immunological advantages over 23vP adults.
Sleep disturbance occurs in most patients with delusions or hallucinations and should be treated as a clinical problem its own right. However, cognitive behavioural therapy (CBT)-the best evidence-based treatment for insomnia-has not been tested this patient population. We aimed to pilot procedures randomised trial testing CBT sleep problems current psychotic experiences, provide preliminary assessment of potential benefit.We did prospective, assessor-blind, controlled (Better Trial [BEST])...
Abstract Background When vaccination depends on injection, it is plausible that the blood-injection-injury cluster of fears may contribute to hesitancy. Our primary aim was estimate in UK adult population proportion COVID-19 vaccine hesitancy explained by fears. Methods In total, 15 014 adults, quota sampled match for age, gender, ethnicity, income and region, took part (19 January–5 February 2021) a non-probability online survey. The Oxford Vaccine Hesitancy Scale assessed intent be...
We explore the implications of online social endorsement for Covid-19 vaccination program in United Kingdom. Vaccine hesitancy is a long-standing problem, but it has assumed great urgency due to pandemic. By early 2021, Kingdom had world’s highest mortality per million population. Our survey nationally representative sample UK adults ( N = 5,114) measured socio-demographics, and political attitudes, media diet getting news about Covid-19, intention use personal messaging apps encourage or...
Analysis of circulating tumour DNA could stratify cancer risk in symptomatic patients. We aimed to evaluate the performance a methylation-based multicancer early detection (MCED) diagnostic test patients referred from primary care.
Automated delivery of psychological therapy using immersive technologies such as virtual reality (VR) might greatly increase the availability effective help for patients. We aimed to evaluate efficacy an automated VR cognitive (gameChange) treat avoidance and distress in patients with psychosis, analyse how whom it work.