To assess the clinical effectiveness of surgical stabilisation (spinal fusion) compared with intensive rehabilitation for patients chronic low back pain.

Investigation of the automation radiological features from magnetic resonance images (MRIs) lumbar spine.To automate process grading intervertebral discs and vertebral bodies MRIs. MR imaging is most common technique used in investigating low back pain (LBP). Various degradation, based on MRIs, are commonly recorded graded, e.g., Modic change Pfirrmann discs. Consistent scoring important for developing robust clinical systems research. Automation facilitates this consistency reduces time...

<h3>Abstract</h3> <b>Objective</b>: To evaluate a progressive fitness programme for patients with chronic low back pain. <b>Design</b>: Single blind randomised controlled trial. Assessments were carried out before and after treatment by an observer blinded to the study included battery of validated measures. All followed up postal questionnaire six months treatment. <b>Setting</b>: Physiotherapy department orthopaedic hospital. <b>Subjects</b>: 81 pain referred from consultants...

Out of 446 pupils aged 13–17 years, 115 were found to have a history back pain. These tended decreased lower limb joint mobility and increased trunk length compared with without In 77 whose site pain was identified, 38 had associated the lumbar spine. an while those thoracolumbar or thoracic did not. Back more common in who avoided sports.

The reproducibility between observers of physical signs in patients with low-back pain was Investigated. Fifty were examined by two surgeons and another sample 33 a surgeon physiotherapist. Continuous data on five analyzed Pearsons' correlation coefficient, binary 54 the Kappa agreement coefficient. Reliable consisted measurements lordosis flexion range, determination lateral bend, nearly all associated straight leg raising test, location In thigh legs, sensory changes legs. Signs root...

Study Design. Oxygen concentrations in intervertebral discs were measured 10 patients during discography and 13 with scoliosis 11 back pain spinal surgery. Lactate concentration profiles 12 of these discs. The graded for degeneration by magnetic resonance maging histology where possible. Objectives. To determine if oxygen lactate levels human vary degree degeneration. Failure nutrient transport is thought to lead disc Summary Background Data. avascular. used the cells, produced. Low high...

Study Design. The Shuttle Walking Test (SWT), the Swiss Spinal Stenosis (SSS) Questionnaire, Oxford Claudication Score (OCS), and Oswestry Disability Index (ODI) were administered to patients with lumbar spinal stenosis neurogenic claudication. Objective. To determine reliability of SWT, SSS (Q1–12), OCS, ODI in assessment. Summary Background Data. Reliability data for exercise tests are lacking. Methods. reliability, 32 clinic assessed twice, 1 week between assessments. Retrospective from...

Twenty-five out of 41 adult patients suffering from their first attack acute low-back pain were subjected to local anesthetic injection into the maximally tender lumbar apophyseal joints under controlled conditions. Two clinical syndromes can be identified according whether responded facet or not. Various differences statistically significant and included a wider than normal spinal canal in responding group. The significance these two distinct groups is discussed detail.

Abstract The distribution of microfibrils was studied immunohistochemically in intervertebral discs taken from young normal human surgical cases and the bovine tail. Co‐localization elastin fibres examined by dual immunostaining fibrillin‐1 elastin. Collagen fibre network orientation using polarized filters. A similar microfibrillar seen both with organization being completely different region to region. In outer annulus fibrosus (OAF), abundant organized bundles were mainly distributed...

<h3>Abstract</h3> <h3>Introduction</h3> Caly, Druce (1) reported that ivermectin inhibited SARS-CoV-2 <i>in vitr</i>o for up to 48 h using at 5μM. The concentration resulting in 50% inhibition (IC_50, 2 µM) was &gt;35x higher than the maximum plasma (Cmax) after oral administration of approved dose when given fasted. <h3>Method</h3> Simulations were conducted an available population pharmacokinetic model predict total (bound and unbound) unbound concentration-time profiles a single...

In Brief Study Design. Immunohistochemical study of elastic fibers in human intervertebral discs (IVD) collected at surgery from patients with scoliosis. Objectives. To compare the fiber network scoliotic (idiopathic scoliosis or neuromuscular scoliosis) to that control (normal) discs. whether change organization could contribute progression spinal deformity. Summary Background Data. Elastin and have been identified previously IVD but were believed little tissue's mechanical properties....

Study Design. Intervertebral disc tissue was analyzed during or removed at routine surgery for correction of scoliosis. Tissue glucose, lactate, oxygen, glycosaminoglycan, collagen concentrations, and cell viability. Objectives. To investigate the viability scoliotic on concave convex sides in relation to curve apex, relate concentrations nutrients, metabolites, extracellular matrix components. Summary Background Data. Compositional differences have been measured deformation discs. However,...

The number of outcome instruments available for use in orthopaedic observational studies has increased dramatically recent years. Properly developed and tested provide a very useful tool research. Criteria have been proposed to assess the measurement properties quality health-status instruments. Unfortunately, not all are with strict criteria. In this article, we discuss these criteria reader help select most appropriate instrument an study. We also review steps future instruments, including...