A5014510851- Health Systems, Economic Evaluations, Quality of Life
- Economic and Environmental Valuation
- Delphi Technique in Research
- Global Health Care Issues
- Healthcare Policy and Management
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Cardiac, Anesthesia and Surgical Outcomes
- Global Maternal and Child Health
- Pregnancy and preeclampsia studies
- Child and Adolescent Health
- Clinical practice guidelines implementation
- Infant Development and Preterm Care
- Healthcare cost, quality, practices
- Patient Safety and Medication Errors
- Intracranial Aneurysms: Treatment and Complications
- Neonatal and fetal brain pathology
- Chronic Disease Management Strategies
- Musculoskeletal pain and rehabilitation
- Healthcare Quality and Management
- Dupuytren's Contracture and Treatments
- Spine and Intervertebral Disc Pathology
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
University of Oxford
2016-2025
Oxford Instruments (United Kingdom)
2024
Nuffield Health
2019-2023
University of Cambridge
2015-2022
St Thomas' Hospital
2022
King's College London
2022
University of Southampton
2022
The Stables
2022
University of Birmingham
2022
Institute for Healthcare Improvement
2022
The Spanish five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) valuation study was the first to use Valuation Technology protocol, including composite time trade-off (C-TTO) and discrete choice experiments (DCE). In this study, its investigators noticed that some interviewers did not fully explain C-TTO task respondents. Evidence from a follow-up in 2014 confirmed when followed distribution of responses widened.To handle data quality issues by estimating hybrid interval regression...
Treatment of hyperglycemia in women with gestational diabetes mellitus (GDM) is associated improved maternal and neonatal outcomes requires intensive clinical input. This currently achieved by hospital clinic attendance every 2 to 4 weeks limited opportunity for intervention between these visits.We conducted a randomized controlled trial determine whether the use mobile phone-based real-time blood glucose management system manage GDM remotely was as effective controlling standard care...
Electronic health records are invaluable for pregnancy-related studies. The Clinical Practice Research Datalink (CPRD) Pregnancy Register (PR) identifies pregnancies in primary care records, including uncertain cases. This paper outlines a method to reduce uncertainty identifying within CPRD GOLD PR data, exemplified through study investigating the provision of pre-pregnancy care. We used Mother Baby Link (MBL) and Maternity Hospital Episode Statistics (HES) clean augment data. included all...
Background. Reliably mapping from generic or diseasespecific health status measures into state utilities would assist economists. Existing studies mainly use ordinary least squares (OLS) regression equations to predict utility values for particular states. The authors examine an alternative approach tomap between 2 instruments, the SF-12 and EQ-5D. Methods. Multinomial logit is used estimate probability that a respondent will select level of response questions in EQ-5D, using individual...
S1 Using computerized adaptive testing Tim Croudace S2 Well-being: what is it, how does it compare to health and are the implications of using inform policy John Brazier O1 “Am I going get better?”—Using PROMs patients about likely benefit surgery Nils Gutacker, Andrew Street O2 Identifying Patient Reported Outcome Measures for an electronic Personal Health Record Dan Robotham, Samantha Waterman, Diana Rose, Safarina Satkunanathan, Til Wykes O3 Examining change process over time...
Background. Mapping disease-specific instruments into generic health outcomes or utility values is an expanding field of interest in economics. This article constructs algorithm to translate the modified Rankin scale (mRS) EQ-5D values. Methods. mRS and information was derived from stroke transient ischemic attack (TIA) patients identified as part Oxford Vascular study (OXVASC). Ordinary least squares (OLS) regression used predict UK tariffs scores. An alternative method, using multinomial...
The EQ-5D instrument is the most widely used preference-based health-related quality of life questionnaire in cost-effectiveness analysis health care technologies. Recently, a version called EQ-5D-5L with 5 levels on each dimension was developed. This manuscript explores performance hybrid approach for modeling valuation data.Two elicitation techniques, composite time trade-off, and discrete choice experiments, were applied to sample Spanish population (n=1000) using computer-based...
BackgroundRisk factors for maternal infection are clearly recognised, including caesarean section and operative vaginal birth. Antibiotic prophylaxis at is widely recommended because there clear systematic review evidence that it reduces incidence of infection. Current WHO guidelines do not recommend routine antibiotic women undergoing birth insufficient effectiveness. We aimed to investigate whether prevented after birth.MethodsIn a blinded, randomised controlled trial done 27 UK obstetric...
Background We tested the hypothesis that routine MRI would improve care and well-being of preterm infants their families. Design Parallel-group randomised trial (1.1 allocation; intention-to-treat) with nested diagnostic cost evaluations (EudraCT 2009-011602-42). Setting Participants from 14 London hospitals, imaged at a single centre. Patients 511 born before 33 weeks gestation underwent both ultrasound around term. 255 were randomly allocated (siblings together) to receive only results...
An international valuation protocol exists for obtaining societal values each of the 3125 health states five-level EuroQol-five dimensions (EQ-5D-5L) questionnaire. A feedback module (FM) that can be related to theoretical models used in behavioral economics was recently included this protocol. Our objective assess impact using an FM estimate EQ-5D-5L value set Hong Kong. were elicited a composite time trade-off (C-TTO) and discrete-choice (DC) experiment. Use according participant...
The EQ-5D-Y-3L is a generic, health-related, quality-of-life instrument for use in younger populations. Some methodological studies have explored the valuation of children's health states. There are currently no published value sets available that appropriate cost-utility analysis. aim this article was to describe development protocol instrument. were several research questions needed be answered develop Most important these were: (1) Do we need obtain separate values EQ-5D-Y-3L, or can ones...
<h3>Importance</h3> Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring BP in the general population has been shown improve diagnosis and hypertension; however, little known about its use pregnancy. <h3>Objective</h3> To determine whether self-monitoring higher-risk pregnancies leads earlier detection pregnancy hypertension. <h3>Design, Setting, Participants</h3> Unblinded, randomized clinical trial that included 2441...
Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role self-monitoring in pregnancy improving clinical outcomes for the pregnant individual and infant unclear.To evaluate effect self-monitoring, compared with usual care alone, on control other related outcomes, individuals hypertension.Unblinded, randomized trial that recruited between November 2018 September 2019 15 hospital maternity units England. Individuals chronic hypertension...
In health preference research (HPR) studies, data are generated by participants'/subjects' decisions. When developing an HPR study, it is therefore important to have a clear understanding of the components decision and how those stimulate participant behavior. To obtain valid reliable results, study designers must sufficiently describe model its components. studies require detailed examination criteria, documentation descriptive framework, specification hypotheses. The objects that subjects'...
<h3>Abstract</h3> <h3>Introduction</h3> Caly, Druce (1) reported that ivermectin inhibited SARS-CoV-2 <i>in vitr</i>o for up to 48 h using at 5μM. The concentration resulting in 50% inhibition (IC<sub>50,</sub> 2 µM) was >35x higher than the maximum plasma (Cmax) after oral administration of approved dose when given fasted. <h3>Method</h3> Simulations were conducted an available population pharmacokinetic model predict total (bound and unbound) unbound concentration-time profiles a single...
To estimate life years and quality-adjusted (QALYs) lost the economic burden of aneurysmal subarachnoid haemorrhage (aSAH) in United Kingdom including healthcare non-healthcare costs from a societal perspective. All UK residents 2005 with aSAH (International Classification Diseases 10th revision (ICD-10) code I60). Sex age-specific abridged tables were generated for general population cohorts. QALYs each cohort calculated adjusting health-related quality (HRQL) data. Healthcare included...