Helen Campbell
A5014703759- Autoimmune and Inflammatory Disorders
- Health Systems, Economic Evaluations, Quality of Life
- IgG4-Related and Inflammatory Diseases
- Total Knee Arthroplasty Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopaedic implants and arthroplasty
- Global Cancer Incidence and Screening
- Musculoskeletal pain and rehabilitation
- Breast Cancer Treatment Studies
- Otitis Media and Relapsing Polychondritis
- Spine and Intervertebral Disc Pathology
- Blood transfusion and management
- Colorectal Cancer Screening and Detection
- Scoliosis diagnosis and treatment
- Cardiac and Coronary Surgery Techniques
- Clinical practice guidelines implementation
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Orthopedic Infections and Treatments
- Healthcare Policy and Management
- Oral Health Pathology and Treatment
- Child and Adolescent Health
- Gastrointestinal Bleeding Diagnosis and Treatment
- Maternal and fetal healthcare
- Global Health Care Issues
University of Oxford
2015-2025
Royal Manchester Children's Hospital
2024
North Bristol NHS Trust
2021-2023
Southmead Hospital
2023
Genomics England
2023
University Hospitals Bristol and Weston NHS Foundation Trust
2023
University Hospitals Bristol NHS Foundation Trust
2023
University of Bristol
2023
Nuffield Health
2023
Betsi Cadwaladr University Health Board
2022
Fresh red cells may improve outcomes in critically ill patients by enhancing oxygen delivery while minimizing the risks of toxic effects from cellular changes and accumulation bioactive materials blood components during prolonged storage.In this multicenter, randomized, blinded trial, we assigned adults to receive either that had been stored for less than 8 days or standard-issue (the oldest compatible units available bank). The primary outcome measure was 90-day mortality.Between March 2009...
Infants with pertussis infection are at risk of severe clinical illness and death. Several countries, including the United Kingdom, have introduced maternal vaccination during pregnancy to protect infants from following national increases in notifications. The objective this study was estimate effectiveness protecting against laboratory-confirmed infection.A case-control undertaken England Wales between October 2012 July 2013. Cases were aged <8 weeks onset tested by real-time polymerase...
Observational data suggest that the use of bilateral internal mammary arteries (BIMA) during coronary artery bypass graft surgery provides superior revascularization to a single (SIMA), but concerns about safety have prevented widespread BIMA. The Arterial Revascularisation Trial (ART) is randomized trial BIMA vs. SIMA, with primary outcome survival at 10 years. This paper reports mortality, morbidity, and resource 1 year. Coronary patients were enrolled in 28 hospitals seven countries....
BackgroundLate-stage isolated medial knee osteoarthritis can be treated with total replacement (TKR) or partial (PKR). There is high variation in treatment choice and little robust evidence to guide selection. The Total Partial Knee Arthroplasty Trial (TOPKAT) therefore aims assess the clinical effectiveness cost-effectiveness of TKR versus PKR patients compartment knee, this represents an analysis main endpoints at 5 years.MethodsOur multicentre, pragmatic randomised controlled trial was...
Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate best management strategy between reconstructive surgery and non-surgical treatment for patients with non-acute ACL persistent symptoms instability.We did pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units UK. Patients symptomatic knee problems (instability) consistent an were...
<h3>Objective</h3> In 2001, the National Institute for Health Research Cancer Network (NCRN) was established, leading to a rapid increase in clinical research activity across English NHS. Using colorectal cancer (CRC) as an example, we test hypothesis that high, sustained hospital-level participation interventional trials improves outcomes all patients with CRC managed those research-intensive hospitals. <h3>Design</h3> Data diagnosed England 2001–2008 (n=209 968) were linked data on accrual...
<h3>Importance</h3> Inadequate management of elevated blood pressure (BP) is a significant contributing factor to maternal deaths. Self-monitoring BP in the general population has been shown improve diagnosis and hypertension; however, little known about its use pregnancy. <h3>Objective</h3> To determine whether self-monitoring higher-risk pregnancies leads earlier detection pregnancy hypertension. <h3>Design, Setting, Participants</h3> Unblinded, randomized clinical trial that included 2441...
Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role self-monitoring in pregnancy improving clinical outcomes for the pregnant individual and infant unclear.To evaluate effect self-monitoring, compared with usual care alone, on control other related outcomes, individuals hypertension.Unblinded, randomized trial that recruited between November 2018 September 2019 15 hospital maternity units England. Individuals chronic hypertension...
<h3>Abstract</h3> <h3>Introduction</h3> Caly, Druce (1) reported that ivermectin inhibited SARS-CoV-2 <i>in vitr</i>o for up to 48 h using at 5μM. The concentration resulting in 50% inhibition (IC<sub>50,</sub> 2 µM) was >35x higher than the maximum plasma (Cmax) after oral administration of approved dose when given fasted. <h3>Method</h3> Simulations were conducted an available population pharmacokinetic model predict total (bound and unbound) unbound concentration-time profiles a single...
Orofacial granulomatosis (OFG) is a rare chronic inflammatory disease of unknown etiology sharing histological features with Crohn's (CD). This study aimed to 1) define the clinical presentation OFG, 2) establish differentiating for those CD, 3) examine if onset OFG predictive and 4) children.Data were extracted from medical notes (n = 207) demographics, features, blood parameters, diagnosis treatment's patients OFG.Ninety-seven (47%) female. The lips (184/203; 91%) buccal mucosa (151/203;...
This investigation was undertaken because of the number reports during last six years suggesting that halothane has hepatotoxic properties.In 1958 Virtue and Payne described a patient who became jaundiced died after cholecystectomy under halothane- nitrous-oxide anaesthesia.At necropsy cause death shown to be necrosis liver pancreas.Halothane not directly blamed treatment this included measures which might equally well have been responsible for damage.In same year Burnap et al. (1958) two...
<h3>Objectives</h3> Data on costs associated with acute upper gastrointestinal bleeding (AUGIB) are scarce. We provide estimates of UK healthcare costs, indirect and health-related quality life (HRQoL) for patients presenting to hospital AUGIB. <h3>Setting</h3> Six university hospitals >20 AUGIB admissions per month, >400 adult beds, 24 h endoscopy, on-site access intensive care surgery. <h3>Participants</h3> 936 aged ≥18 years, admitted AUGIB, enrolled between August 2012 March 2013...
Background The survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role the pathophysiology of number pediatric cancers. We report first child study recombinant human arginase, BCT-100, hematological, solid or CNS Procedure PARC was single arm, Phase I/II, international, open label study. BCT-100 given intravenously over one hour at weekly intervals. I section utilized modified 3 + design where...
Adjuvant! Online is an internet-based computer programme providing 10-year prognosis predictions for early breast cancer patients. It was developed in the United States, has been successfully validated Canada, and used Kingdom elsewhere. This study investigates performance of a cohort patients from Kingdom. Data on prognostic factors management 1065 women with diagnosed consecutively at Churchill Hospital Oxford between 1986 1996 were entered into to generate overall survival (OS),...
Intensive follow-up after surgery for colorectal cancer is common practice but lacks a firm evidence base.
Background Late-stage medial compartment knee osteoarthritis can be treated using total replacement or partial (unicompartmental) replacement. There is high variation in treatment choice and insufficient evidence to guide selection. Objective To assess the clinical effectiveness cost-effectiveness of compared with patients osteoarthritis. The findings are intended surgical decision-making for patients, surgeons health-care providers. Design This was a randomised, multicentre, pragmatic...
Orofacial granulomatosis (OFG) causes chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. A proportion cases have co-existing intestinal Crohn's disease (CD). The pathogenesis is unknown but has recently been linked to dietary sensitivity. Although allergy suggested as an aetiological factor in OFG there are few published data support this link. In study, we sought clinical evidence a series patients with compared inflammatory bowel (IBD) without involvement...
ABSTRACT Objective To assess the cost‐effectiveness of modifying current antenatal screening by adding first trimester structural anomaly to standard care second screening. Design Health economic decision model. Setting National Service (NHS) in England and Wales. Population Pregnant women attending for Methods The model estimated pregnancy outcomes (maternal foetal) 20‐year costs practice a policy protocol eight major anomalies ultrasound scan. Event probabilities, costs, were informed...
Aim To investigate, for preterm babies born between 27 +0 and 31 +6 weeks gestation in England, optimal place of birth early care. Design Mixed methods. Setting National Health Service neonatal care, England. Methods investigate whether care intensive units (tertiary units) compared to local (non-tertiary influenced gestation-specific survival other major outcomes, we analysed data from the Neonatal Research Database, 29,842 discharged 1 January 2014 December 2018. We utilised an...
To provide reliable estimates of the long-term cost-effectiveness abdominal aortic aneurysm screening in men.A Markov health economic decision model for is described and extrapolated to 30 years. The strategy modelled involves a one-off scan at age 65 years, with annual three-monthly follow-up scans small medium aneurysms, respectively. Referral elective surgery occurs an diameter 5.5 cm. Model parameters are estimated from patient-level data UK Multi-centre Aneurysm Screening Study....