A5078714410- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Bleeding Diagnosis and Treatment
- Microscopic Colitis
- Cancer Treatment and Pharmacology
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Inflammatory Bowel Disease
Addenbrooke's Hospital
2020-2025
Cambridge University Hospitals NHS Foundation Trust
2021-2023
University Hospital Southampton NHS Foundation Trust
2012-2022
NIHR Evaluation Trials and Studies Coordinating Centre
2022
University of Southampton
2008-2021
University of Cambridge
2021
NRG Oncology
2014-2020
Southampton General Hospital
2014-2016
University of Oxford
2014
Taunton & Somerset NHS Foundation Trust
2010-2013
BackgroundThe interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction progression-free survival allocated to cetuximab plus chemotherapy compared those given alone. The focus present was assess effect on overall survival.MethodsNew multicentre, open-label, randomised, controlled, phase 3 trial. Adult (aged ≥18 years) KRAS wild-type (codons 12, 13, and 61) or suboptimally metastases WHO performance status 0–2...
PURPOSE To compare outcomes after laparoscopic versus open major liver resection (hemihepatectomy) mainly for primary or metastatic cancer. The outcome measure was time to functional recovery. Secondary included morbidity, quality of life (QoL), and those with cancer, margin status adjuvant systemic therapy. PATIENTS AND METHODS This a multicenter, randomized controlled, patient-blinded, superiority trial on adult patients undergoing hemihepatectomy. Patients were recruited from 16 hospitals...
Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence the association recent cancer treatment type mortality.
Objective To evaluate the diagnostic accuracy of a single CEA (carcinoembryonic antigen) blood test in detecting colorectal cancer recurrence. Background Patients who have undergone curative resection for primary are typically followed up with scheduled testing 5 years. Decisions to investigate further (usually by CT imaging) based on results, reflecting international guidelines. Methods A secondary analysis was undertaken data from FACS trial (two arms included testing). The composite...
To describe patterns of recurrence and postrecurrence survival in a large cohort accurately staged patients with Dukes' A-C colorectal cancer.
Personalized treatment approaches for patients with oligometastatic colorectal liver metastases are critically needed. We previously defined 3 biologically distinct molecular subtypes of metastases: (1) canonical, (2) immune, and (3) stromal.
Intensive follow-up after surgery for colorectal cancer is common practice but lacks a firm evidence base.
// Siân Pugh 1, * , Raphaële Thiébaut 2, John Bridgewater 3, Marie-Lise Grisoni 2 Karwan Moutasim 4 Francis Rousseau Gareth J. Thomas Griffiths 5 François Liebaert Primrose and Pierre Laurent-Puig 6, 7, 1 University Surgery, Cancer Sciences, of Southampton, United Kingdom IntegraGen SA, Evry, France 3 UCL Institute, London, Sciences Division, Southampton Clinical Trials Unit, 6 UMR-S1147, Paris Descartes, Paris, 7 Assistance Publique-Hôpitaux de Hôpital Georges Pompidou, These authors have...
Objective Cytotoxic agents are the cornerstone of treatment for patients with advanced intrahepatic cholangiocarcinoma (iCCA), despite heterogeneous benefit. We hypothesised that pretreatment molecular profiles diagnostic biopsies can predict patient benefit from chemotherapy and define bases innate chemoresistance. Design identified a cohort iCCA comparable baseline characteristics who diverged as extreme outliers on (survival <6 m in rapid progressors, RP; survival >23 long...
In order to identify factors associated with peptic ulcers which present bleeding rather than pain, we have prospectively evaluated patient and endoscopic features in 139 consecutive patients presenting acute 74 pain found ulceration at endoscopy. Patients were more likely taken non-steroidal anti-inflammatory drugs within the preceding four weeks (58% v 18%, p less 0.001). They older (66 51 years, 0.001), had a previous ulcer complication (21% 1%, an diameter greater 20 mm (27% 6%, 0.05)....
Summary In 1986, 292 patients were admitted to a joint medical-surgical gastrointestinal unit with upper haemorrhage. Fourteen died (4.8%) mortality considerably lower than recorded in most series. The low may result from the use of specialized which all haemorrhage are and managed strict protocols for resuscitation, transfusion surgery.
Summary Background Systemic corticosteroids are effective in ulcerative colitis but commonly cause side effects. Aim To compare the safety and efficacy of a sparingly absorbed formulation prednisolone metasulfobenzoate (Predocol) with conventional tapering course oral prednisolone. Method In double‐blind randomized study, 59 active patients received Predocol 40 mg/day for 6 months, 61 60 months 2 weeks, tapered to week 8, followed by placebo until months. Results Steroid‐related effects...
The adaptive immune response to colorectal cancer is important for survival. Less understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver. Samples fresh liver (n = 21) and tumour 11) tissue were obtained from patients undergoing surgical resection metastases. Flow cytometry was used analyse presence phenotype NK compared T tissue. Results correlated with cells poorly recruited tumours (distant 38.3%, peritumoural 34.2%, 12.9%, p...
Abstract Background Most guidelines recommend that patients who have undergone curative resection for primary colorectal cancer are followed up 5 years with regular blood carcinoembryonic antigen (CEA) tests to trigger further investigation recurrence. However, CEA may miss recurrences, or false alarms and undergo unnecessary investigation. Methods The diagnostic accuracy of trends in measurements recurrent cancer, taken as part the FACS (Follow-up After Colorectal Surgery) trial...
Acute pancreatitis is a common surgical emergency. Identifying variations in presentation, incidence and management may assist standardisation optimisation of care. The objective the study was to document current outcomes acute against international guidelines, assess temporal trends over past 20 years.A prospective four-month audit patients with performed across Wessex region. Atlanta 2012 classifications were used define cases, severity complications. Outcomes recorded using validated...
Abstract Background A shift towards parenchymal-sparing liver resections in open and laparoscopic surgery emerged the last few years. Laparoscopic resection is technically feasible safe, consensus guidelines acknowledge approach posterosuperior segments. Lesions situated these segments are considered most challenging for approach. The aim of this trial to compare postoperative time functional recovery, complications, oncological safety, quality life, survival costs after versus within an...
The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details disease progression are described further inform the primary study outcome. A total 257 KRAS wild-type patients were randomised CT alone or with CTX. Data regarding sites and treatment progressive obtained 109 (CT n=48, CTX n=61) at cut-off date analysis November 2012. was most frequent site 67% (32/48); 66% (40/61)). higher...
3500 Background: Intensive long-term follow-up after surgery for colorectal cancer is common practice but neither the actual benefit nor optimal methodology known. Methods: Pragmatic factorial randomised controlled trial in 39 UK hospitals, comparing minimum (which included a single CT scan at 12-18 months) with 3-6 monthly blood carcinoembryonic antigen (CEA) testing and 6-12 computerised tomography (CT) imaging of chest, abdomen pelvis following 1202 participants 3-5 (mean 3.7) years....