Jesper B. Andersen
A5033807990- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Amino Acid Enzymes and Metabolism
- Ubiquitin and proteasome pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Biochemical Acid Research Studies
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Gallbladder and Bile Duct Disorders
- Protein Degradation and Inhibitors
University of Copenhagen
2016-2025
Loma Linda University
2022
Fudan University
2021
Centre de Nanosciences et de Nanotechnologies
2021
IT University of Copenhagen
2020-2021
Huashan Hospital
2021
Peking Union Medical College Hospital
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
The University of Texas MD Anderson Cancer Center
2018
National Institutes of Health
2009-2016
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe integrated analysis somatic mutations, RNA expression, copy number, DNA methylation by The Cancer Genome Atlas a set predominantly intrahepatic CCA cases propose molecular classification scheme. We identified IDH mutant-enriched subtype distinct features including low expression chromatin modifiers, elevated mitochondrial genes, increased number....
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death. Despite advances in diagnosis and management HCC, biology this tumor remains poorly understood. Recent evidence highlighted long noncoding RNAs (lncRNAs) as crucial determinants HCC development. In study we report lncRNA HOXA transcript at distal tip (HOTTIP) significantly up-regulated specimens. The HOTTIP gene located physical contiguity with HOXA13 directly controls locus expression by way interaction...
Intrahepatic cholangiocellular carcinoma (ICC) is the second most common type of primary liver cancer. However, its tumor heterogeneity and molecular characteristics are largely unknown. In this study, we conducted transcriptomic profiling 23 ICC combined hepatocellular cholangiocarcinoma specimens from Asian patients using Affymetrix messenger RNA (mRNA) NanoString microRNA microarrays to search for unique gene signatures linked subtypes patient prognosis. We validated in an additional 68...
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
Hepatocellular carcinoma (HCC) is the third cancer killer worldwide with >600,000 deaths every year. Although major risk factors are known, therapeutic options in patients remain limited part because of our incomplete understanding cellular and molecular mechanisms influencing HCC development. Evidence indicates that retinoblastoma (RB) pathway functionally inactivated most cases by genetic, epigenetic, and/or viral mechanisms. To investigate functional relevance this observation, we...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types The Cancer Genome Atlas (TCGA). Focusing on genes encode mediators and regulators TGF-β signaling, we found at least one genomic alteration (mutation, homozygous deletion, or amplification) 39% samples, with highest frequencies gastrointestinal cancers. identified mutation hotspots ligands (BMP5), receptors (TGFBR2,...
Abstract KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, deeper understanding molecular mechanisms triggered by oncogene may yield alternative therapeutic strategies. Here we report identification common transcriptional signature across mutant cancers distinct tissue origin that includes transcription factor FOSL1. High FOSL1 expression identifies lung and pancreatic cancer patients with worst...
Human hepatocellular carcinoma (HCC) is a heterogeneous disease of distinct clinical subgroups. A principal source tumor heterogeneity may be cell type origin, which in liver includes hepatocyte or adult stem/progenitor cells. To address this issue, we investigated the molecular mechanisms underlying fate enzyme-altered preneoplastic lesions resistant (RH) model. Sixty samples classified as focal lesions, adenoma, and early advanced HCCs were microdissected after morphological...