A5050092994- Arsenic contamination and mitigation
- Chromium effects and bioremediation
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- Heavy Metal Exposure and Toxicity
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Pesticide and Herbicide Environmental Studies
- Microbial metabolism and enzyme function
- Heavy metals in environment
- Plant Stress Responses and Tolerance
- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Insect-Plant Interactions and Control
- Natural Antidiabetic Agents Studies
- Microbial bioremediation and biosurfactants
- Electrochemical sensors and biosensors
- Enzyme Catalysis and Immobilization
- Biopolymer Synthesis and Applications
- Biochemical and Molecular Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Enzyme-mediated dye degradation
- Toxic Organic Pollutants Impact
- Amino Acid Enzymes and Metabolism
- Plant Micronutrient Interactions and Effects
Chinese Academy of Sciences
2011-2024
Florida International University
2015-2024
Institute of Solid State Physics
2024
Jinan University
2022-2024
Huainan Mining Industry Group (China)
2022-2024
Guangzhou Institute of Geochemistry
2022-2023
Jiangnan University
2010-2023
Institute of Botany
2016-2023
Southwest Forestry University
2019-2023
Fujian Agriculture and Forestry University
2009-2023
Arsenic (As) is a pervasive and ubiquitous environmental toxin that has created worldwide human health problems. However, there are few studies about how organisms detoxify As. Cyanobacteria capable of both photolithotrophic growth in the light heterotrophic dark soils, aquatic systems, wetlands. In this study, we investigated As biotransformation three cyanobacterial species (Microcystis sp. PCC7806, Nostoc PCC7120, Synechocystis PCC6803). Each accumulated large amounts As, up to 0.39 g...
Summary Environmental organoarsenicals are produced by microorganisms and introduced anthropogenically as herbicides antimicrobial growth promoters for poultry swine. Nearly every prokaryote has an ars (arsenic resistance) operon, some have arsH gene encoding atypical flavodoxin. The role of ArsH in arsenic resistance been unclear. Here we demonstrate that is organoarsenical oxidase detoxifies trivalent methylated aromatic arsenicals oxidation to pentavalent species. E scherichia coli ,...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad-mediated signaling in 9,125 tumor samples across 33 cancer types The Cancer Genome Atlas (TCGA). Focusing on genes encode mediators and regulators TGF-β signaling, we found at least one genomic alteration (mutation, homozygous deletion, or amplification) 39% samples, with highest frequencies gastrointestinal cancers. identified mutation hotspots ligands (BMP5), receptors (TGFBR2,...
Even though arsenic is one of the most widespread environmental carcinogens, methods remediation are still limited. In this report we demonstrate that a strain Pseudomonas putida KT2440 endowed with chromosomal expression arsM gene encoding As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopseudomonas palustris to remove contaminated soil. We genetically engineered P. stable an arsM-gfp fusion (GE putida), which was inserted into bacterial chromosome. GE showed high methylation...
Although magnesium (Mg2+) is the most abundant divalent cation in plant cells, little known about mechanism of Mg2+ uptake by roots. Here, we report a key function Magnesium Transport6 (MGT6)/Mitochondrial RNA Splicing2-4 and low-Mg2+ tolerance Arabidopsis thaliana. MGT6 expressed mainly aerial tissues when levels are high soil or growth medium. Its expression highly induced roots during deficiency, suggesting role for response to status Silencing transgenic plants interference (RNAi)...
Summary Trivalent organoarsenic compounds are far more toxic than either pentavalent organoarsenicals or inorganic arsenite. Many microbes methylate arsenite ( A s( III )) to and carcinogenic methylarsenite MAs )). Additionally, monosodium methylarsenate MSMA V has been used widely as an herbicide is reduced by microbial communities ). Roxarsone (3‐nitro‐4‐hydroxybenzenearsonic acid) a aromatic arsenical that antimicrobial growth promoter for poultry swine, its active form the trivalent...
Arsenic is the most ubiquitous environmental toxin. Most microorganisms have evolved mechanisms to use methylarsenicals as weapons in microbial warfare. This has created cycles of arsenic methylation and demethylation, which constitutes an important part biogeochemical health. forms methylarsenite (MAs(III)), arsenobetaine, arsenosugars new identified methylarsenical antibiotic, arsinothricin (AST). Bacteria MAs(III) AST gain a competitive advantage over other bacteria. Microbes generate...
Microbial biotransformations are major contributors to the arsenic biogeocycle. In parallel with transformations of inorganic arsenic, organoarsenicals pathways have recently been recognized as important components global cycling arsenic. The well-characterized pathway resistance arsenate is reduction coupled arsenite efflux. Here, we describe a new involving biosynthesis and extrusion an unusual pentavalent organoarsenical. A number (ars) operons two genes unknown function that linked in...
Accumulation of arsenic has potential health risks through consumption food. Here, we inserted the arsenite [As(III)] S-adenosylmethionine methyltransferase (ArsM) gene into chromosome Pseudomonas putida KT2440. Recombinant bacteria methylate inorganic less toxic organoarsenicals. This for bioremediation environmental and reducing contamination in
Summary Arsenic is the most ubiquitous environmental toxin. Here, we demonstrate that bacteria have evolved ability to use arsenic gain a competitive advantage over other at least twice. Microbes generate toxic methylarsenite (MAs(III)) by methylation of arsenite (As(III)) or reduction methylarsenate (MAs(V)). MAs(III) oxidized aerobically MAs(V), making detoxification process. MAs(V) continually re‐reduced community members, giving them sensitive bacteria. Because generation sustained pool...
Characterization of genetic circuits and biosynthetic pathways in different hosts always requires promoter substitution redesigning. Here, a strong, broad-spectrum promoter, Pbs, for Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae was constructed, it incorporated into the minimal E. coli–B. subtilis–S. shuttle plasmid pEBS (5.8 kb). By applying random mutation strategy, three promoters Pbs1, Pbs2, Pbs3, with strengths were generated characterized. These will expand synthetic...
In this study, blueberry (Vaccinium ssp.) anthocyanins (VA) and blackberry (Rubus L.) (RA) were used to investigate the effects on metabolic syndrome (MetS) potential mechanisms. Importantly, all of data presented in study obtained from experiments conducted mice. As a result, VA RA reduced body weight gain fat accumulation while improving liver damage, inflammation, glucose, lipid metabolism induced by high-fat diet. Moreover, regulated gut microbiota composition, decreasing pro-obesity...
The toxic metalloid arsenic is widely distributed in food, water, and soil. While inorganic enters the environment primarily from geochemical sources, methylarsenicals either result microbial biotransformation of or are introduced anthropogenically. Methylarsenicals such as monosodium methylarsonic acid (MSMA) have been extensively utilized herbicides, aromatic arsenicals roxarsone (Rox) used growth promoters for poultry swine. Organoarsenicals degraded to arsenic. toxicological effects...
Microbes play a critical role in the global arsenic biogeocycle. Most studies have focused on redox cycling of inorganic bacteria and archaea. The parallel cycles organoarsenical biotransformations are less well characterized. Here we describe environmental microbe Shewanella putrefaciens. Under aerobic growth conditions, S. putrefaciens reduced herbicide MSMA (methylarsenate or MAs(V)) to methylarsenite (MAs(III)). Even though it does not contain an arsI gene, which encodes ArsI C-As lyase,...
Coix, Sorghum and Zea are closely related plant genera in the subtribe Maydeae. Coix comprises 9–11 species with different ploidy levels (2n = 10, 20, 30, 40). The exclusively cultivated C. lacryma-jobi L. 20) is widely used East Southeast Asia for food medicinal applications. Three fertile cytotypes 40) have been reported aquatica Roxb. One sterile cytotype 30) to has recently found Guangxi of China. This putative hybrid named HG (Hybrid Guangxi). genome composition evolutionary history...
Arsenic is a ubiquitous metalloid found in the environment. Its chronic exposure of global health concern as it causes lung, skin and bladder cancers, well non-cancer illness such lesions, cardiovascular neurological diseases. While environmental occurrence, fate, toxicity inorganic As has been documented, limited research available on organic compounds. Organic compounds often result from metabolism marine organisms, but they also enter biosphere through anthropogenic activities including...