A5067575158- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Erythropoietin and Anemia Treatment
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Metabolism, Diabetes, and Cancer
- Gastric Cancer Management and Outcomes
- Hedgehog Signaling Pathway Studies
- Securities Regulation and Market Practices
University of Milan
2020-2025
Humanitas University
2014-2021
Vita-Salute San Raffaele University
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2020
Cholangiocarcinoma (CCA) is a devastating liver tumour arising from malignant transformation of bile duct epithelial cells. Cancer stem cells (CSC) are subset endowed with stem-like properties, which play role in initiation, recurrence and metastasis. In appropriate conditions, CSC form 3D spheres (SPH), retain tumour-initiating features. Here, we found different expression iron proteins indicating increased content, oxidative stress higher markers CCA-SPH compared to growing as monolayers....
Iron is an essential nutrient for growth among all branches of life, but while iron the most common elements, bioavailable a relatively scarce nutrient. Since fundamental several biological processes, deficiency can be deleterious. On other hand, excess may lead to cell and tissue damage. Consequently, balance strictly regulated. As excretion not physiologically controlled, systemic homeostasis maintained at level absorption, which mainly influenced by amount stores erythropoietic activity,...
Summary Iron is required for key physiological processes, like oxygen transport, energy production and cell proliferation. Body iron homeostasis regulated by the erythroferrone–hepcidin–ferroportin (FPN) axis, which mainly acts on absorptive duodenal cells macrophages involved in recycling from red blood breakdown. In addition to systemic regulation, are also local release neighbouring cells. Similarly, bone marrow (BM)‐resident could represent promptly available sources of developing...
Epithelial linings are crucial for the maintenance of physiological barriers. The intestinal epithelial barrier (IEB) consists enterocytes through tight junctions and mucus-secreting cells can undergo modifications throughout life. To reproduce as closely possible IEB main features over time, in vitro co-cultures Caco2/HT-29 70/30 formed by parental Caco2 HT-29 sub-cultivated more than 40 passages were set up. measurements transepithelial electrical resistance (TEER) identified two...
Abstract Background and aims Cholangiocarcinoma (CCA) is a form of primary liver cancer with limited therapeutic options. Recently, stem cells (CSCs) have been proposed as driving force tumour initiation dissemination, thus representing crucial target. The protease inhibitor SerpinB3 (SB3) has identified in several malignancies including hepatocellular carcinoma. SB3 involved the early events hepatocarcinogenesis highly expressed hepatic progenitor mouse model cell activation. However, only...
Abstract: The polymerase chain reaction (PCR) was applied to the detection of human papillomavirus (HPV) infection in biopsies taken from clinically normal oral mucosa 20 subjects and clinical lesions 40 patients. PCR for HPV‐DNA amplification performed using consensus primers MYO9/MYO11 subsequent typing HPV high low oncogenic risk types were identified by restriction enzyme analysis (restriction fragment length polymorphism, RFLP). viral genome present 55% (22/40) benign (OBL) 10% (2/20)...
Iron is required for hemoglobin synthesis and red blood cell (RBC) production. When erythropoiesis stimulated, erythroferrone, a hormone produced by erythroblasts in response to erythropoietin (EPO), downregulates hepcidin transcription the liver. Lower levels facilitate ferroportin-mediated iron absorption duodenum export from reticuloendothelial cells that process old/damaged RBCs,1 thereby ensuring availability erythropoietic compartment. During acute high-altitude hypoxia, increased...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Of the approximately 18,000 new cases of cancer in Venezuela each year, only half can be treated with surgery and radiation. The remainder must systematically using chemotherapy or biological response modifiers. It has become evident that any drug resistant human tumors express MDR1 gene, since RNA levels are elevated many cancers do not respond to chemotherapy. Human mammary carcinomas have multiple oncogene alterations, most frequently reported being overexpression oncogenes c-myc, int-2,...
ABSTRACT Background & Aims GD2, a member of the ganglioside (GS) family (sialic acid‐containing glycosphingolipids), is potential biomarker cancer stem cells (CSC) in several tumours. However, possible role GD2 and its biosynthetic enzyme, GD3 synthase (GD3S), intrahepatic cholangiocarcinoma (iCCA) has not been explored. Methods The stem‐like subset two iCCA cell lines was enriched by sphere culture (SPH) compared to monolayer parental (MON). GS profiles were evaluated chromatography,...