A5051159995- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Atmospheric chemistry and aerosols
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Geology and Paleoclimatology Research
- Cancer Research and Treatments
- Galectins and Cancer Biology
- Infectious Diseases and Mycology
- Retinal and Macular Surgery
- Immune Response and Inflammation
- Polar Research and Ecology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Caveolin-1 and cellular processes
- Protease and Inhibitor Mechanisms
- Antifungal resistance and susceptibility
- Isotope Analysis in Ecology
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Amino Acid Enzymes and Metabolism
University of Florence
2007-2024
Cambridge University Press
2009
New York University Press
2009
Electrical signals elicited by integrin interaction with ECM components and their role in neurite outgrowth were studied two clones (N1 N7) isolated from 41A3 murine neuroblastoma cell line. Although the similarly adhered to fibronectin (FN) vitronectin (VN), this adhesion induced N1 but not N7 cells. Patch clamp recordings whole configuration showed that, upon FN or VN platelet factor 4 (PF4), cells undergo a marked (approximately equal 20 mV) hyperpolarization of resting potential (Vrest)...
The MDR phenomenon has become a major obstacle in the treatment of cancers, and among strategies to reverse it, inhibition P-gp function expression is essential increase for effective anticancer drugs. In present paper, co-delivery berberine chloride tariquidar loaded nanoliposomes was investigated with aim enhancing solubility improving desired effects antineoplastic drug inhibitor. Developed were electron-dense enzyme horseradish peroxidase, analyzed by TEM investigate their ability enter...
During the 2002–2003 austral summer field season, aerosol samples were collected at a coastal (Terra Nova Bay—Northern Victoria Land) and an inland site (Dome C—East Antarctic Plateau). The sampling was carried out by stacked filter units made up of two filters different porosity (5.0 0.4 μm Terra Bay 3.0 Dome C), able to roughly separate coarse from fine fraction. At C, further investigation on size distribution performed inertial impactor collect particles 8 classes (from 10 μm). Atomic...
Abstract Background Human Amniotic Membrane (hAM) is endowed with several biological activities and might be considered an optimal tool in surgical treatment for different ophthalmic pathologies. We pioneered the use of hAM to treat retinal pathologies such as macular holes, tears, detachments, overcome photoreceptor damage age-related degeneration. Although contributed improved outcomes, mechanisms its effects are not yet fully understood. The characterization explanation would allow...
Both epidemiological and experimental studies indicate that dietary n-3 PUFA inhibit carcinogenesis tumour growth. Metastatic diffusion has also been found to be affected in animals fed diets containing purified or fish oil. In the present study, we investigated whether metastatic of a highly variant (F10-SR cells) isolated from B16 melanoma F10 line was by feeding host diet 5 % these animals, compared with those maize oil, there reduced number pulmonary colonies. The immunohistochemical...
Epidemiological investigation and animal studies have shown that dietary n-3 PUFA prevent the development progression of certain types cancer. However, conflicting results been reported by few focused on effect metastases. In present study, we investigated metastatic dissemination murine T lymphoma lines with different potential transplanted into mice fed a fish oil diet, compared maize diet. Transplantation highly S11 cells animals diet induced large lymphomatoid infiltration in spleen,...
// Theodora Stivarou 1, 4, * , Maria Grazia Cipolleschi Massimo D'Amico 2 Antonella Mannini 3 Enrico Mini Elisabetta Rovida 1 Persio Dello Sbarba Olivotto Ilaria Marzi Department of Experimental and Clinical Biomedical Science, University Florence, Italy DI.V.A.L. Toscana s.r.l., Medicine, 4 Hellenic Pasteur Institute, Athens, Greece These authors have contributed equally to this work Correspondence to: Marzi, e-mail: ilariamarzi1@gmail.com Keywords: hypoxia, embryonic transcription factors,...
In addition to its well-established immunosuppressive actions, tryptophan 2,3-dioxygenase (TDO) appears elicit direct effects on tumor cell function. Although TDO has been associated with cancer stemness, involvement in melanoma stem biology remains largely unknown. Since we showed that by upregulating TDO, dexamethasone (dex) promotes proliferation and migration of SK-Mel-28 human cells, sought investigate dex spherogenesis whether these events are mediated TDO. We demonstrate here...
Abstract To determine which structural characteristics of membrane phospholipids influence adenylate cyclase activity, we measured basal and sodium fluoride‐ or forskolin‐stimulated activity in a murine fibroblast cell line, i.e. , Balb/c3T3 cells grown media supplemented with fetal calf serum (FCS), lipid‐depleted FCS (LD‐FCS) LD‐FCS complexed different phosphatidylcholine (PC) molecular species. Cells the presence showed substantial decrease their NaF‐stimulated activities; however, was...
ABSTRACT Background & Aims GD2, a member of the ganglioside (GS) family (sialic acid‐containing glycosphingolipids), is potential biomarker cancer stem cells (CSC) in several tumours. However, possible role GD2 and its biosynthetic enzyme, GD3 synthase (GD3S), intrahepatic cholangiocarcinoma (iCCA) has not been explored. Methods The stem‐like subset two iCCA cell lines was enriched by sphere culture (SPH) compared to monolayer parental (MON). GS profiles were evaluated chromatography,...
ガングリオシドなどの細胞表面の構成成分がフィブロネクチンをふくむ細胞外環境中のいくつかの生体活性物質を認識できる事実により、昔から接着過程に高級ガングリオシドが関与すると考えられていた。つまり、初期の研究では高級ガングリオシドがフィブロネクチンの受容体として機能している可能性が調べられた。しかし、ガングリオシドのフィブロネクチン受容体としての役割が納得いくまで立証されたことはなかった。さらに、インテグリンがマトリックス接着性タンパク質の細胞表在性糖タンパク質受容体であることが分かり、細胞接着におけるガングリオシドの役割は不確かなものとなった。その後、接着部位の分子構築の、言い換えれば細胞の組織培養基質への接着を仲介する構造の、観察からそこに高級ガングリオシドが優先的に分配されていることが分かった。さらに、接着部位でインテグリン受容体と高級ガングリオシドが一緒に存在していることも分かった。これらの発見により、高級ガングリオシドが細胞接着に関与している可能性を再び髣髴させ、高級ガングリオシドとインテグリンのような細胞接着に関与する構成成分間での相互作用に焦点が定められた。実際、細胞外...