A5013362774- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Cancer and Skin Lesions
- Optical Coherence Tomography Applications
- melanin and skin pigmentation
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Genetic and rare skin diseases.
- Autoimmune Bullous Skin Diseases
- Advanced Fluorescence Microscopy Techniques
- Ocular Oncology and Treatments
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
- Cell Image Analysis Techniques
- Skin Protection and Aging
- Infectious Diseases and Mycology
- Dermatologic Treatments and Research
- Ear and Head Tumors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tumors and Oncological Cases
University of Florence
2016-2025
New York University
2024
Department of Medical Sciences
2024
European Organisation for Research and Treatment of Cancer
2023-2024
Mater Adult Hospital
2024
Azienda Ospedaliero-Universitaria Careggi
2009-2023
European Organisation for Research and Treatment of Cancer
2023
National Research Council
2019-2022
Institute for Marine Biological Resources and Biotechnology
2022
Pathological Society
2013-2021
Purpose The prevalence of BRAF, NRAS, and p16CDKN2A mutations during melanoma progression remains inconclusive. We investigated the distribution in these genes different tissues. Patients Methods In all, 291 tumor tissues from 132 patients with were screened. Paired samples primary melanomas (n = 102) synchronous or asynchronous metastases same 165) included. Tissue underwent mutation analysis (automated DNA sequencing). Secondary lesions included lymph nodes 84), skin 36), visceral 25),...
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through unknown mechanism does not involve TRPV1. We hypothesized 2 alpha,beta-unsaturated aldehydes present CS, crotonaldehyde and acrolein, induce neurogenic inflammation TRPA1, excitatory ion channel coexpressed with TRPV1 on nociceptors. found CS aqueous extract...
Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature classification.This study analyzes 48 cases primary cutaneous lymphoma proteins and/or NK marker, CD56. These were collected workshop European Organization Research Treatment Cancer Lymphoma Task Force, to better clarify clinical, morphologic, phenotypic features these...
Purpose Primary care physicians (PCPs) constitute an appropriate target for new interventions and educational campaigns designed to increase skin cancer screening prevention. The aim of this randomized study was determine whether the adjunct dermoscopy standard clinical examination improves accuracy PCPs triage lesions suggestive cancer. Patients Methods in Barcelona, Spain, Naples, Italy, were given a 1-day training course detection dermoscopic evaluation, randomly assigned evaluation arm...
Background Because of the many limitations studies based on diagnostic setting excised lesions, impact dermoscopy (epiluminescence microscopy, dermatoscopy) in melanoma screening during practice remains to be established. Objectives We assumed that effects use some indicators performance should traceable retrospectively; therefore, we analysed routine malignant/benign ratio melanocytic lesions. Methods Preoperative and histological diagnosis 3053 lesions [319 melanomas (10·4%)] consecutively...
We have used nonlinear imaging to evaluate collagen organization in connective tissue ex-vivo samples. Image analysis methods were tested on healthy dermis, normal scars, and keloids. The evaluation of the second harmonic autofluorescence aging index dermis (SAAID) has allowed a first characterization tissues by scoring collagen/elastin content. Further analyses morphology keloids performed image-pattern SHG images. gray-level co-occurrence matrix (GLCM) method classification different based...
PD-L1 is expressed by a subset of patients with metastatic melanoma (MM) an unfavorable outcome. Its expression increased in cells resistant to BRAF or MEK inhibitors (BRAFi MEKi). However, the function and regulation remain incompletely understood.After generating BRAFi- MEKi-resistant cell lines, we observed marked up-regulation expression. These were characterized common gene profile genes involved movement. Consistently, vitro they showed significantly invasive properties. This phenotype...
Resistance to anti-PD1-based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well host myeloid can express ligand CD155 regulate cell function. However, effect tumor on context human melanoma has not been described. This observational study characterizes expression by tumors and correlates results with differences in features response ICB.Pretreatment specimens, from 155 patients treated ICB 50 BRAF/MEK-directed targeted therapy,...
Importance A standardized pathology classification system for melanocytic lesions is needed to aid both pathologists and clinicians in cataloging currently existing diverse terminologies the diagnosis treatment of patients. The Melanocytic Pathology Assessment Tool Hierarchy Diagnosis (MPATH-Dx) has been developed this purpose. Objective To revise MPATH-Dx version 1.0 tool, using feedback from dermatopathologists participating National Institutes Health–funded Reducing Errors Interpretations...