A5028359701- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- NF-κB Signaling Pathways
- Vascular Tumors and Angiosarcomas
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- TGF-β signaling in diseases
- Toxin Mechanisms and Immunotoxins
Brown University
2020-2024
University of Virginia
2023-2024
Rhode Island Hospital
2017-2023
Providence College
2014-2023
Creative Commons
2017-2022
Boston University
2010-2021
Roger Williams Medical Center
2012-2021
Lifespan
2019-2020
Cornell University
2019
Jersey Shore University Medical Center
2017
An analysis is presented of the histopathologic, clinical, and prognostic features in a series 405 previously untreated patients with non-Hodgkin's lymphomas referred to Stanford University Medical Center between 1960 1971. All biopsies were histologically classified according criteria Rappaport et al. clinical extent disease was thoroughly evaluated prior treatment staged Ann Arbor Classification. Nodular constituted 44% group diffuse 56%. Patients under age 35 years those over 60 tended...
A recent association between breast implants and the development of anaplastic large-cell lymphoma (ALCL) has been observed. The purpose this study was to identify whether bacterial biofilm is present in implant-associated ALCL and, if so, compare microbiome nontumor capsule samples from with contracture.Twenty-six were analyzed for presence by real-time quantitative polymerase chain reaction, next-generation sequencing, fluorescent situ hybridization, scanning electron microscopy, compared...
THE occasional occurrence of a granulomatous process in tissues involved by Hodgkin's disease has long been recognized.1 , 2 However, the presence noncaseating tubercle-like granulomas within otherwise uninvolved organs patients with is not well known. To date, only isolated cases this finding have reported3 4 5 6 and thought some to represent coexistent sarcoidosis.5 Of great concern us interpretation these as additional foci referred institution.We encountered this, yet unexplained,...
In the absence of high-quality evidence, there is a need for guidelines and multidisciplinary consensus recommendations on breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). The purpose this expert conference was to evaluate existing evidence regarding diagnosis management BIA-ALCL caused by textured implants. This article aims provide evidence-based prevention BIA-ALCL.
PURPOSE: Current standard therapy for children and adolescents with Hodgkin’s disease includes combination chemotherapy low-dose involved-field radiation (LD-IFRT). Because may be associated adverse late effects, the Children’s Cancer Group (CCG) investigated whether could omitted in patients achieving a complete response to initial without jeopardizing excellent outcome obtained combined-modality therapy. PATIENTS AND METHODS: Between January 1995 December 1998, 829 eligible were enrolled...
Lymphomatoid papulosis is a benign cutaneous eruption that in 10 to 20 percent of patients associated with the development lymphoma. The atypical cells lymphomatoid histologically resemble malignant T-cell lymphoma or Reed-Sternberg Hodgkin's disease. We studied patient whom developed 1971, disease 1975, and 1985, determine whether these diseases are clonally related.
Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature classification.This study analyzes 48 cases primary cutaneous lymphoma proteins and/or NK marker, CD56. These were collected workshop European Organization Research Treatment Cancer Lymphoma Task Force, to better clarify clinical, morphologic, phenotypic features these...
We describe nine patients with a primary Ki-1 (CD30)+ T-cell lymphoma containing numerous, often CD30-negative, small lymphocytes irregular nuclei and minor population of large CD30+ tumor cells. All previously described Ki-1+ lymphomas have been large-cell neoplasms. In this small-cell variant, the diagnosis was difficult to make because there predominance and, in some cases, clinical features suggested an inflammatory process. Patients were young (age range 0.3–40 years, median 14 years),...
CLINICOPATHOLOGICAL studies suggest that the T-cell lymphomas are heterogeneous with respect to clinical presentation, course, and morphology. Mycosis fungoides Sézary syndrome affect skin primarily, slowly progressive, characterized by peripheral T cells cerebriform nuclei infiltrate epidermis.1 lymphoblastic lymphoma often presents as a mediastinal mass, commonly spreads bone marrow central nervous system, is rapidly fatal.2 , 3 Other variants of distinctive pathologic features have been...
The pathologic findings in 117 untreated patients subjected to laparotomy for the staging of Hodgkin's disease, at Stanford University Medical Center, were correlated with preoperative clinical evaluation. validity and applicability modified classification Lukes, Butler, Hicks confirmed, consistency histologic pattern multiple lesions was verified. Nodular sclerosis most frequent type encountered showed a predilection mediastinum (81%), high incidence abdominal involvement (39%). recognition...
A potentially fatal hemophagocytic syndrome has been noted in patients with malignant lymphomas, particularly EBV-infected T cell lymphoma. Cytokines, such as interferon-gamma (IFN-gamma), TNF-alpha, and IL-1alpha, are elevated patients' sera. To verify whether infection of cells by EBV will upregulate specific cytokine genes subsequently activate macrophages leading to syndrome, we studied the transcripts IFN-gamma, IL-1alpha EBV-negative lymphoma tissues. By reverse transcription PCR...
Signaling through the interleukin 2 receptor (IL-2R) involves phosphorylation of several proteins including Jak3, STAT5, and, in preactivated cells, STAT3. In present study, we examined functional status IL-2R-associated Jak/STAT pathway malignant T lymphocytes from advanced skin-based lymphomas: anaplastic large T-cell lymphoma (ALCL) and Sezary syndrome (SzS). Proliferation three ALCL cell lines (PB-1, 2A, 2B) was partially inhibited by rapamycin, a blocker some signals mediated IL-2R, but...
Ki-1 (CD30)+ cutaneous T-cell lymphomas CTCLs) are slowly progressive in which initial spontaneous regression is often observed. To better understand the mechanisms of and eventual tumor progression Ki-1+ CTCLs, type beta transforming growth factor (TGF-beta)-mediated inhibition clonally related cell lines derived from two time points, before after progression, was studied. TGF-beta 1 inhibited colony-forming efficiency (CFE) a line (Mac-1) clinically indolent CTCLs but failed to inhibit CFE...
Lymphomatoid papulosis (LyP) is an indolent cutaneous lymphoproliferative disorder with clinical and pathologic features overlapping those of both reactive conditions aggressive lymphomas. Recurrent genetic abnormalities in LyP have not been previously identified. Here, we describe the clinical, immunophenotypic, characteristics lesions showing distinctive undescribed histologic 11 patients. All patients were older adults (67 to 88 y) predominantly localized presentations suggesting benign...
We studied Reed-Sternberg cells from 14 patients with Hodgkin's disease to learn whether they had monoclonal immunoglobulin synthesized by the cell or polyclonal of external origin. Double-label immunofluorescence F(ab')2 anti-serums human light chains showed that cytoplasmic individual is always and usually associated membrane-bound same type. The predominant was IgG; in one case IgM also present. In vitro studies confirmed internalization exogenous IgG phagocytosis immune complexes viable...
Abstract Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and vivo has shown clinical responses ∼30% patients with advanced mycosis fungoides Sézary syndrome cutaneous T-cell lymphoma (CTCL). The purpose this study was to identify biomarkers predictive vorinostat response CTCL using preclinical model systems assess these samples. signal transducer activator transcription (STAT) signaling pathway...
In 1995, the Children's Cancer Group (CCG) opened a trial for patients with Hodgkin's lymphoma evaluating whether low-dose involved-field radiation therapy (IFRT) improved event-free survival (EFS) achieving complete response after chemotherapy. We present long-term study outcome using final data through March 2007.