A5021457538- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Vascular Tumors and Angiosarcomas
- Cancer and Skin Lesions
- Sarcoma Diagnosis and Treatment
- Cardiac tumors and thrombi
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Genomic variations and chromosomal abnormalities
- Ear and Head Tumors
- CNS Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Fungal Infections and Studies
- Neonatal skin health care
- Prenatal Screening and Diagnostics
- T-cell and Retrovirus Studies
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Skin Protection and Aging
- Salivary Gland Tumors Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
Institut für Hämatopathologie Hamburg
2020-2025
Fachklinik Hornheide
2010-2023
Dermatologikum Hamburg
2021-2023
Heidelberg University
2012
University of Göttingen
2001-2011
University of Münster
2006-2007
Cancer Genetics (United States)
2004
Leiden University Medical Center
2004
Columbia University
2004
University of Würzburg
2002
Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature classification.This study analyzes 48 cases primary cutaneous lymphoma proteins and/or NK marker, CD56. These were collected workshop European Organization Research Treatment Cancer Lymphoma Task Force, to better clarify clinical, morphologic, phenotypic features these...
Granulomatous cutaneous T-cell lymphomas (CTCLs) are rare and represent a diagnostic challenge. Only limited data on the clinicopathological prognostic features of granulomatous CTCLs available. We studied 19 patients with to further characterize clinicopathological, therapeutic, features.The group included 15 mycosis fungoides (GMF) 4 slack skin (GSS) defined according World Health Organization-European Organization for Research Treatment Cancer classification lymphomas. Patients GMF GSS...
Cutaneous lymphomas expressing CD56, a neural cell adhesion molecule, are characterised in most cases by highly aggressive clinical course and poor prognosis. However, prognostic subsets within the CD56+ group have been difficult to identify due lack of uniform clinicopathological immunophenotypical criteria.A multicentre study was conducted Lymphoma Task Force European Organisation for Research Treatment Cancer define parameters establish diagnostic therapeutic guidelines haematological...
The aim of this study was retrospectively to assess the validity 2005 WHO-EORTC classification for primary cutaneous lymphomas (PCL) in a large cohort patients single German skin cancer unit. All with PCLs consecutively visiting our hospital between January 1980 and December were included retrospective monocentre study, analysing their histological clinical data. A total 312 fulfilled inclusion criteria PCL. In 299 information paraffin material sufficient detailed classification. Of...
Basosquamous carcinoma (BSC) is a rare tumor entity, and the most common onset in head neck region (BSC-HN). The data on diagnosis, treatment, especially risk assessment concerning disease course outcome are deficient or inconsistent. This study aimed to evaluate factors for local relapse (LR) lymph node metastasis (LNM) their impact progression-free survival (PFS).In retrospective monocentric study, patients with BSC-HN treated between 1999 2011 were analyzed regarding clinical histologic...
Background Enhancer of zeste homolog 2 (EZH2) is a transcriptional enzyme implicated in tumor development and often correlated to poor patient outcomes various malignancies. The study evaluated methods for EZH2 expression lip ear squamous cell carcinomas (LSCC, ESCC) by matching patients with without lymph node metastasis (LNM) further analysis clinical outcome parameters. inhibition therapy has shown promising results multiple cancer entities, ongoing research exploring its potential other...
Patients with a high number of atypical naevi and personal and/or family history melanoma are at risk malignant melanoma. The objective this study was to design special documentation surveillance programme using epiluminescence microscopy (ELM) digital (DELM) improve the these patients. High-risk patients (n=212) were categorized by phenotype their Then screened unaided eye, conventional photography, ELM and, in selected cases atypia, DELM. Median follow-up 18 months, 2939 pigmented lesions...
The purpose of this study was to assess the value biometric lung measurements for prediction severe fetal pulmonary hypoplasia in congenital diaphragmatic hernia and determine whether a correlation between autopsy findings or neonatal outcome could be established.Prospective study, 1991 1997.Nineteen fetuses with hernia.In addition standard biometry, sonographic measurement transverse thoracic diameter, sagittal diameters at level four-chamber view lung/thoracic circumference ratio were...
Abstract Irradiation is a major causative factor among the small subgroup of sarcomas with known etiology. The prognosis radiation‐induced (RIS) significantly worse than that their spontaneous counterparts. most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency MYC amplifications in but not primary has recently been described. To investigate whether are also RIS other we analyzed amplification status 83 192...
Abstract Introduction: Tumor cells of primary cutaneous T‐cell lymphomas are able to adopt a regulatory phenotype in vitro . The significance this finding vivo is matter debate. Methods: We stained five cases with transformed mycosis fungoides (MF) an antibody against FOXP3, which sensitive and specific marker for the phenotype. Results: Transformed T four patients MF positive FOXP3. One patient who showed no CD30 expression large was also negative Comparison plaques tumors one that FOXP3...
Pulmonary hypoplasia was diagnosed sonographically in 32 fetuses from 20 to 33 weeks of gestation. In addition standard biometry, transverse thoracic diameter (TTD), sagittal (TSD), circumference (TC) and lung (LD) were measured all cases compared with known nomograms. The divided into five groups according the main sonographic findings: group 1—skeletal dysplasia; 2—renal agenesis; 3—diaphragmatic hernia; 4—hydrothorax; 5—others. Severe pulmonary (PH) prenatally on basis LD measurements. 17...
Patients belonging to xeroderma pigmentosum (XP) complementation group C comprise one-third of all XP patients. Only four major reports compiled larger groups XP-C patients from southern Europe (12 pts), North America (16 pts) and Africa (14 56 as well their genetic background (46 XPC mutations). We identified 16 Germany. Interestingly, only five exhibited severe sun sensitivity. The mean age diagnosis was 9.4 years, the median first skin cancer 7 years. Neurological symptoms were absent in...
Cutaneous angiosarcoma of head and neck (cAS-HN) is a malignant neoplasm with deficient data on prognostic factors. The aim this study to present our monocenter database cAS-HN so far new predictive score for locoregional metastasis (LRM).Retrospectively, tumor characteristics outcome 103 consecutive patients were analyzed. main predictors LRM (identified by univariate multivariate statistics) combined risk score. values stratification into high-, medium-, low-risk groups concerning...
Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by accumulation of Th1‐type T cells and neutrophils, regenerative keratinocyte proliferation differentiation, enhanced epidermal production antimicrobial peptides. The underlying cause unknown, but there are some similarities with the immunologic defense program against bacteria. Development psoriasiform lesions has been reported after administration granulocyte colony‐stimulating factor (G‐CSF), cytokine induced in...