A5034080950- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Cutaneous Melanoma Detection and Management
- Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
- Autoimmune Bullous Skin Diseases
- Whipple's Disease and Interleukins
- Nonmelanoma Skin Cancer Studies
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- Skin and Cellular Biology Research
- Histiocytic Disorders and Treatments
- Synthesis and characterization of novel inorganic/organometallic compounds
- Contact Dermatitis and Allergies
- Organometallic Complex Synthesis and Catalysis
- Mast cells and histamine
- Carcinogens and Genotoxicity Assessment
- Monoclonal and Polyclonal Antibodies Research
- Nail Diseases and Treatments
Heidelberg University
2008-2025
University Hospital Heidelberg
2023-2025
Global Policy Institute
2024
University of Mannheim
2022
European Union of Medical Specialists
2022
Krankenhaus Meran
2022
Digital Science (United States)
2022
Behörde für Gesundheit und Verbraucherschutz
2022
Christ University
2022
Robert Koch Institute
2022
Background. CD30 (Ki-1)-positive anaplastic large cell lymphoma (LCL) has been described as a morphologically distinct group of LCL that generally are associated with poor prognosis. Recent studies indicate these lymphomas, when confined to the skin, have favorable However, there is no consensus regarding definition primary cutaneous CD30-positive LCL. Reported patients selected variously on basis morphologic (anaplastic cytology) or immunophenotypical (expression antigen) criteria. Methods....
Abstract Unfractionated murine spleen cells produce immune interferon (type II) upon stimulation with antigen or mitogen. When were passed over glass bead columns, production decreased whereas the mitotic response to stimulants drastically increased. these further purified nylon wool was totally abolished thymidine incorporation in stimulated cultures invariably high. Interferon by column‐purified lymphocytes could be restored macrophages grown from bone marrow but not proteose...
Mechanisms regulating the balance of T-helper 1 (Th1) and 2 (Th2) immune responses are great interest as they may determine outcome allergic infectious diseases. Recently, in mice, nitric oxide (NO), a powerful modulator inflammation, has been reported to preferentially down-regulate Th1-mediated responses. In present study, we investigated effect NO on production Th1- Th2-associated cytokines by activated human T cells T-cell clones. Cytokine secretion was measured presence NO-donating...
Individuals with the rare DNA repair deficiency syndrome xeroderma pigmentosum (XP) are sensitive to sun and exhibit a 1000-fold increased risk for developing skin cancers, including cutaneous melanoma. Inherited polymorphisms of XP genes may contribute subtle variations in capacity genetic susceptibility We investigated role three polymorphic alleles gene XPC hospital-based case–control study 294 Caucasian patients from Germany who had melanoma 375 healthy cancer-free sex-matched control...
Abstract Interleukin (IL)‐13 is a cytokine originally identified as product of activated T cells. Little known, however, about IL‐13 production by human cells and its modulation other cytokines. Here, we show that produced CD4 + CD8 CD45R0 memory CD45RA naive In contrast, IL‐4, which shares many biological activities with IL‐13, only following activation. Analysis intracellular single indicated continued to be for more than 24 h after stimulation, whereas IL‐4 could not detected h. These...
In the presence of a colony-stimulating factor, murine bone marrow cells proliferate and differentiate into macrophages. This culture system was taken as model to study expression various functions by macrophages in course maturation. Several tests were performed daily parallel from same batch cells. It found that certain expressed early also characteristic for mature such Fc receptors, phagocytosis latex beads unspecific esterase activity. Other appeared disappeared an ordered sequence,...
Background: Epidermolysis bullosa acquisita (EBA) is an autoimmune bullous disorder with mucocutaneous involvement, skin fragility, and tendency to scarring.The mechanobullous form of EBA has a chronic relapsing course difficult treat.We describe herein the therapeutic response 2 patients recalcitrant combined treatment immunoadsorption rituximab, anti-CD20 monoclonal antibody that induces depletion B cells in vivo.Observations: Two received resulting almost complete clinical remission one...
Abstract Background Prostate-specific membrane antigen (PSMA) SPECT imaging in prostate cancer (PCa) could be a valuable alternative regions where access to PSMA-PET is restricted. [ 99m Tc]Tc-PSMA-I&S new Tc-labeled PSMA-targeting agent, initially developed for radio-guided surgery. We report on the diagnostic use of Tc]Tc-PSMA-I&S-SPECT/CT PCa. Results was performed and evaluated 210 outpatients with PCa at single center. Patients were imaged biochemical recurrence (BCR, n = 152,...
Abstract Background In Burkina Faso, nearly half of the population is under 15 years old, and one in four adolescents experience depression. This underscores critical need to enhance mental health literacy among youth, empowering them manage their well-being effectively. Comic books offer an engaging approach education, yet effectiveness addressing remains largely untested. Our study aims fill this gap by evaluating comic enhancing young adults aged 10–24 years. Methods We will recruit 2,007...
Malignant melanoma has been shown to be susceptible T cell-mediated immunity and, therefore, is a candidate for vaccination approaches. Clinical trials using dendritic cells (DC) loaded with peptides corresponding tumor antigens are ongoing in several institutions, and some promising results have already published. However, every single peptide-based vaccine can only used patient given HLA type, this strategy not appropriate patients rare types or tumors without defined antigens. A clinical...