Carola Berking
A5056685282- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- melanin and skin pigmentation
- Ocular Oncology and Treatments
- AI in cancer detection
- Photodynamic Therapy Research Studies
- Computational Drug Discovery Methods
- Optical Coherence Tomography Applications
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Advanced Breast Cancer Therapies
- Cell Image Analysis Techniques
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Allergic Rhinitis and Sensitization
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2025
Comprehensive Cancer Center Erlangen
2020-2025
Universitätsklinikum Erlangen
2019-2025
German Climate Computing Centre
2021-2025
Bayer (Germany)
2025
Ludwig-Maximilians-Universität München
2013-2024
LMU Klinikum
2011-2024
Zero to Three
2020-2023
Hautklinik Heidelberg
2022
München Klinik
2008-2019
Most patients with BRAF(V600)-mutant metastatic melanoma develop resistance to selective RAF kinase inhibitors. The spectrum of clinical genetic mechanisms inhibitors and options for salvage therapy are incompletely understood. We performed whole-exome sequencing on formalin-fixed, paraffin-embedded tumors from 45 who received vemurafenib or dabrafenib monotherapy. Genetic alterations in known putative inhibitor genes were observed 23 (51%). Besides previously characterized alterations, we...
Recently, we and others identified the microRNA miR-34a as a target of tumor suppressor gene product p53. Ectopic induces G(1) cell cycle arrest, senescence apoptosis. Here report that expression is silenced in several types cancer due to aberrant CpG methylation its promoter. 19 out 24 (79.1%) primary prostate carcinomas displayed promoter concomitant loss expression. was also detected breast (6/24; 25%), lung (7/24; 29.1%), colon (3/23; 13%), kidney (3/14; 21.4%), bladder (2/6; 33.3%)...
Biomarkers for outcome after immune-checkpoint blockade are strongly needed as these may influence individual treatment selection or sequence. We aimed to identify baseline factors associated with overall survival (OS) pembrolizumab in melanoma patients.Serum lactate dehydrogenase (LDH), routine blood count parameters, and clinical characteristics were investigated 616 patients. Endpoints OS best response following treatment. Kaplan-Meier analysis Cox regression applied analysis.Relative...
Background Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% patients. Treatment algorithms management common ipilimumab-induced AEs have lead reduction morbidity, e.g. due bowel perforations. However, spectrum less is expanding as ipilimumab increasingly applied. Stringent recognition will reduce drug-induced morbidity costs, thus, positively impact cost-benefit...
The retinoic acid–inducible gene I (RIG-I) and melanoma differentiation–associated antigen 5 (MDA-5) helicases sense viral RNA in infected cells initiate antiviral responses such as the production of type IFNs. Here we have shown that RIG-I MDA-5 also a proapoptotic signaling pathway is independent In human cells, this required mitochondrial adapter Cardif (also known IPS-1) induced BH3-only proteins Puma Noxa. RIG-I– MDA-5–initiated apoptosis Noxa but was tumor suppressor p53. Triggering...
Recent studies have successfully demonstrated the use of deep-learning algorithms for dermatologist-level classification suspicious lesions by excessive proprietary image databases and limited numbers dermatologists. For first time, performance a algorithm trained open-source images exclusively is compared to large number dermatologists covering all levels within clinical hierarchy.We used methods from enhanced deep learning train convolutional neural network (CNN) with 12,378 dermoscopic...
BackgroundMelanoma is the most dangerous type of skin cancer but curable if detected early. Recent publications demonstrated that artificial intelligence capable in classifying images benign nevi and melanoma with dermatologist-level precision. However, a statistically significant improvement compared dermatologist classification has not been reported to date.MethodsFor this comparative study, 4204 biopsy-proven (1:1) were used for training convolutional neural network (CNN). New techniques...
BackgroundIn recent studies, convolutional neural networks (CNNs) outperformed dermatologists in distinguishing dermoscopic images of melanoma and nevi. In these artificial intelligence were considered as opponents. However, the combination classifiers frequently yields superior results, both machine learning among humans. this study, we investigated potential benefit combining human for skin cancer classification.MethodsUsing 11,444 images, which divided into five diagnostic categories,...
Purpose Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option metastatic setting. Selumetinib (AZD6244, ARRY-142886) an oral, potent, and selective MEK1/2 inhibitor a short half-life, which demonstrated single-agent activity patients uveal randomized phase II trial. Methods The (AZD6244: (Hyd-Sulfate) Metastatic Melanoma (SUMIT) study was III, double-blind trial ( ClinicalTrial.gov identifier: NCT01974752) prior therapy were...
BackgroundThe diagnosis of most cancers is made by a board-certified pathologist based on tissue biopsy under the microscope. Recent research reveals high discordance between individual pathologists. For melanoma, literature reports 25–26% for classifying benign nevus versus malignant melanoma. Deep learning was successfully implemented to enhance precision lung and breast cancer diagnoses. The aim this study illustrate potential deep assist human assessment histopathologic melanoma...
PURPOSE We have previously reported on the 3-year results of phase III German Dermatologic Cooperative Oncology Group trial (DeCOG; ClinicalTrials.gov identifier: NCT02434107 ) comparing distant metastasis-free survival (DMFS), recurrence-free (RFS), and overall (OS) in patients with positive sentinel lymph-node biopsy who were randomly assigned to complete lymph node dissection (CLND) or observation. Here, we report final analysis 72 months median follow up. PATIENTS AND METHODS The...
BackgroundMultiple studies have compared the performance of artificial intelligence (AI)–based models for automated skin cancer classification to human experts, thus setting cornerstone a successful translation AI-based tools into clinicopathological practice.ObjectiveThe objective study was systematically analyse current state research on reader involving melanoma and assess their potential clinical relevance by evaluating three main aspects: test set characteristics...