A5070194877- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Polyomavirus and related diseases
- Nonmelanoma Skin Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Gut microbiota and health
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Plant Virus Research Studies
- Clinical Nutrition and Gastroenterology
- Head and Neck Cancer Studies
- Testicular diseases and treatments
- IL-33, ST2, and ILC Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Cutaneous lymphoproliferative disorders research
- Craniofacial Disorders and Treatments
University of Alberta
2012-2025
Princess Margaret Cancer Centre
2024
University of Toronto
2024
Walker (United States)
2024
University of Florida Health
2024
Cancer Institute (WIA)
2020-2022
College of the Holy Cross
2020
Children's Hospital of Los Angeles
2001-2015
University of Kentucky
2013
Denver Health Medical Center
2012
There remains an unmet need to improve clinical outcomes in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN).
Juvenile hemangiomas are the most common tumors of infancy, occurring in as many 10% all births. These benign vascular lesions enlarge rapidly during first year life by hyperplasia endothelial cells and attendant pericytes then spontaneously involute over a period years, leaving loose fibrofatty tissue. Several hypotheses have been put forth concerning hemangiogenesis, including possibility that tumor is result somatic mutation one or more components critical growth-regulatory pathways. To...
Abstract Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand (PD-L1) interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there have been enormous efforts to develop potent PD-1/PD-L1 inhibitors. In particular, Bristol-Myers Squibb (BMS) and Aurigene Discovery Technologies individually disclosed several promising inhibitors, whose detailed experimental data are not publicly disclosed. this work, we report rigorous systematic vitro...
Avelumab, a human anti-programmed death-ligand 1 immunoglobulin G1 monoclonal antibody, showed favorable efficacy and safety in patients with metastatic Merkel cell carcinoma (mMCC) the phase II JAVELIN 200 trial, leading to approval multiple countries. We describe real-world experience avelumab mMCC from an expanded access program.Eligible had progressive disease during or after chemotherapy were ineligible for clinical trial participation. Patients received initial 3-month supply of...
Abstract Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for monitoring antiviral immunity and vaccine design. Currently, both impaired robust cell described in COVID-19 patients. In this study, we explored compared effector functions SARS-CoV-2–reactive expressing coinhibitory receptors examine immunogenicity S, M, N peptide pools regard to specific responses, Th1/Th2/Th17, Analyzing a cohort 108 patients with mild, moderate, severe disease, observed that (e.g.,...
SummaryBackground & aimsExisting skeletal muscle index (SMI) thresholds for sarcopenia are inconsistent, and do not reflect severity of depletion. In this study we aimed to define criterion values moderate severe depletion based on the risk mortality in a population patients with head neck cancer (HNC). Additionally, identify clinical demographic predictors depletion, evaluate survival impact minimal nutritional or good performance status, finally, benchmarking SMI HNC against healthy young...
AMPK (AMP-activated protein kinase) is a key sensor of energy status within the cell. Activated by an increase in AMP/ATP ratio, acts to limit cellular depletion down-regulating selective ATP-dependent processes. The purpose present study was determine role regulating intestinal glucose transport. [3H]3-O-methyl fluxes were measured murine jejunum presence and absence activators AICAR (5-aminoimidazole-4-carboxamide riboside) metformin p38 inhibitor, SB203580. To differentiate between...
Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. are non-invasive attaching/effacing (A/E) bacterial pathogens that infect their host's intestinal epithelium, causing severe diarrhoeal disease. These bacteria utilize a type III secretion apparatus to deliver effector molecules into host cells, subverting cellular function. Mitochondrial associated protein (Map) is multifunctional targets cell mitochondria contributes infection-induced epithelial barrier dysfunction in...
Deep venous thrombosis and pulmonary embolus are known risks of surgery. However, the incidence these conditions in face lift is unknown. In this study, deep thrombosis/pulmonary after studied factors associated with thromboembolic complications evaluated. One-third active members American Society for Aesthetic Plastic Surgery were randomly selected. Participating surgeons completed a one-page survey providing information on face-lift procedures during 12-month study period. A response rate...
Abstract Introduction Objective response rates (ORR) appear to be higher in melanoma patients who develop immune-related adverse events (irAEs), but whether there is a similar association between irAEs and survival remains unknown. Materials Methods Patients with advanced treated single-agent pembrolizumab or nivolumab the province of Alberta from June 2014 May 2017 were identified through provincial pharmacy database. Chart review categorized all that occurred while on anti–programmed cell...
Patients undergoing evaluation for solid organ transplantation (SOT) frequently have a history of malignancy. Only patients with treated cancer are considered SOT but the benefits need to be balanced against risk tumor recurrence, taking into consideration potential effects immunosuppression. Prior guidelines on timing transplant in prior malignancy do not account current staging, disease biology, or advances treatments. To update these recommendations, American Society Transplantation (AST)...
Background We have previously reported that the upregulation of galectin-9 (Gal-9) on CD4 + and CD8 T cells in HIV patients was associated with impaired cell effector functions. Gal-9 is a ligand for immunoglobulin mucin domain-3, its expression cancer has not been investigated. Therefore, we aimed to investigate level effects functions virus-associated solid tumors (VASTs). Methods 40 VASTs through non-randomized biomarker-driven phase II LATENT trial were Peripheral blood mononuclear tumor...
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. However, only a portion patients respond to such treatments. Therefore, it remains prevailing clinical need identify factors associated with acquired resistance or lack response ICIs. We hypothesized that immunosuppressive CD71 + erythroid cells (CECs) within tumor and/or distant ‘out-of-field’ may impair antitumor response. Methods studied 38 cancer through phase II trial investigating effects oral...
Talimogene laherparepvec (T-VEC) is an intralesionally delivered, modified herpes simplex virus type-1 oncolytic immunotherapy. The biodistribution, shedding, and potential transmission of T-VEC was systematically evaluated during after completion therapy in adults with advanced melanoma.In this phase 2, single-arm, open-label study, administered into injectable lesions initially at 106 plaque-forming units (PFU)/mL, 108 PFU/mL 21 days later, every 14 (±3) thereafter. Injected were covered...