A5040432597- Nutrition and Health in Aging
- Head and Neck Cancer Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Dysphagia Assessment and Management
- Head and Neck Surgical Oncology
- Cancer, Hypoxia, and Metabolism
- Nuclear Structure and Function
- Frailty in Older Adults
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- GDF15 and Related Biomarkers
- Immune Response and Inflammation
- Genomics and Chromatin Dynamics
- Sarcoma Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Craniofacial Disorders and Treatments
- Adipose Tissue and Metabolism
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Cleft Lip and Palate Research
- Cancer, Stress, Anesthesia, and Immune Response
Mayo Clinic
2023-2025
Mayo Clinic in Arizona
2024-2025
WinnMed
2025
Oregon Health & Science University
2018-2024
Yale University
2016-2021
Peripheral blood MФ–cancer cell fusion hybrids identified in cancer patients correlate with disease stage and overall survival.
A priority in cancer research is to innovate therapies that are not only effective against tumor progression but also address comorbidities such as cachexia limit quality and quantity of life. We demonstrate TLR7/8 agonist R848 induces anti-tumor responses attenuates murine models pancreatic ductal adenocarcinoma (PDAC). In vivo, tumors from two three cell lines were R848-sensitive, resulting smaller mass, increased immune complexity, CD8+ T-cell infiltration activity, decreased Treg...
<h3>Importance</h3> Sarcopenia, or the loss of muscle mass, is associated with poor treatment outcomes in a variety surgical fields. However, association between sarcopenia and long-term survival broad cohort patients head neck cancer (HNC) unknown. <h3>Objective</h3> To determine whether undergoing major surgery for HNC. <h3>Design, Setting, Participants</h3> A retrospective medical records review was conducted at tertiary care academic hospital. Two hundred sixty ablative procedures...
Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator appetite. However, it remains unknown if this molecule influences appetite during cancer cachexia, devastating clinical entity characterized by decreased nutrition and progressive wasting. We demonstrate that LCN2 is robustly upregulated in murine models pancreatic cancer, its expression associated with reduced food consumption, Lcn2 deletion protective from...
SummaryBackground & aimsExisting skeletal muscle index (SMI) thresholds for sarcopenia are inconsistent, and do not reflect severity of depletion. In this study we aimed to define criterion values moderate severe depletion based on the risk mortality in a population patients with head neck cancer (HNC). Additionally, identify clinical demographic predictors depletion, evaluate survival impact minimal nutritional or good performance status, finally, benchmarking SMI HNC against healthy young...
Objective To examine implementation of virtual reality (VR) and Fitbit wearable activity devices in postoperative recovery. Methods This was a prospective, 4‐arm, randomized controlled trial patients undergoing inpatient head neck surgery at tertiary academic center from November 2021 to July 2022. Patients were Control, VR, Fitbit, or combined VR + groups. the groups brought headsets use throughout each day, wore encouraged achieve 2,000 daily steps. The primary outcome average opioid use,...
Alterations in the apoptosis of immune cells have been associated with autoimmunity. Here, we identified a homozygous missense mutation gene encoding base excision repair enzyme Nei endonuclease VIII-like 3 (NEIL3) that abolished enzymatic activity siblings from consanguineous family. The NEIL3 was fatal recurrent infections, severe autoimmunity, hypogammaglobulinemia, and impaired B cell function these individuals. same also an asymptomatic individual who exhibited elevated levels serum...
Abstract Background Up to 80% of pancreatic cancer patients suffer from cachexia, a devastating condition that exacerbates underlying disease, reduces quality life, and increases treatment complications mortality. Tumour‐induced inflammation is linked this multifactorial wasting syndrome, but mechanisms effective treatments remain elusive. Myeloid differentiation factor (MyD88), key component the innate immune system, plays pivotal role in directing inflammatory response various insults. In...
Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of therapy. Inflammation the brain is a driver these symptoms, yet cellular sources neuroinflammation during malignancy unknown. In mouse model pancreatic ductal adenocarcinoma (PDAC), we observed early robust myeloid cell infiltration into brain. Infiltrating immune cells were predominately neutrophils, which accumulated at unique central nervous system entry portal called velum interpositum,...
Toll-like receptors 7 and 8 (TLR7 TLR8) are endosomal pattern recognition that detect a variety of single-stranded RNA species. While TLR7/8 agonists have robust therapeutic potential, clinical utility these agents is limited by sickness responses associated with treatment induction. To understand the kinetics mechanism responses, we characterized acute chronic effects TLR7 stimulation. Single-cell RNA-sequencing studies, RNAscope, radiolabeled in situ hybridization demonstrate central...
Lipocalin 2 (LCN2) is a pleiotropic molecule that induced in the central nervous system (CNS) several acute and chronic pathologies. The induction of LCN2 evolved as beneficial process, aimed at combating bacterial infection through sequestration iron from pathogens, while role during chronic, non-infectious disease remains unclear, recent studies suggest neurotoxic. However, whether sufficient to induce behavioral cognitive alterations unclear. In this paper, we sought address cerebral on...
The negative association of low lean muscle mass (sarcopenia) with survival outcomes in head and neck cancers, including oropharyngeal carcinoma, is established. However, it not known whether the choice primary treatment modality (surgery or radiotherapy) associated oncologic patients sarcopenia squamous cell carcinoma (OPSCC).
Microglia in the mediobasal hypothalamus (MBH) respond to inflammatory stimuli and metabolic perturbations mediate body composition. This concept is well studied context of high fat diet induced obesity (HFDO), yet has not been investigated cachexia, a devastating syndrome characterized by anorexia, fatigue, muscle catabolism. We show that microglia accumulate specifically MBH early pancreatic ductal adenocarcinoma (PDAC)-associated cachexia assume an activated morphology. Furthermore, we...
Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly understood. In particular, hypothalamus may play central role in cachexia, given that it has direct access to peripheral signals because of its anatomical location attenuated blood–brain barrier. Furthermore, region critical regulating appetite metabolism. To...
Sarcopenia is a prognostic factor in patients with head and neck cancer (HNC). can be determined using the skeletal muscle index (SMI) calculated from cervical (SM) segmentations. However, SM segmentation requires manual input, which time-consuming variable. Therefore, we developed fully-automated approach to segment vertebra SM.390 HNC contrast-enhanced CT scans were utilized (300-training, 90-testing). Ground-truth single-slice segmentations at C3 manually generated. A multi-stage deep...
Metastatic progression significantly reduces survival rates and complicates treatment strategies in various cancers. Our study introduces an mRNA therapy for metastasis inhibition by targeting activin A overexpression, a pivotal driver of cachexia. Utilizing follistatin lipid nanoparticles, we effectively downregulated both locally the tumor environment systemically. This led to reduction burden suppression metastatic spread murine head neck squamous cell carcinoma model. Treated mice...
Abstract This study presents the first messenger RNA (mRNA) therapy for metastatic ovarian cancer and cachexia‐induced muscle wasting based on lipid nanoparticles that deliver follistatin (FST) mRNA predominantly to clusters following intraperitoneal administration. The secreted FST protein, endogenously synthesized from delivered mRNA, efficiently reduces elevated activin A levels associated with aggressive cachexia. By altering cell phenotype, treatment prevents malignant ascites, delays...