A5019419984- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Immune Response and Inflammation
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Macrophage Migration Inhibitory Factor
- 3D Printing in Biomedical Research
- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Microtubule and mitosis dynamics
- Brain Metastases and Treatment
- Immunotherapy and Immune Responses
- Nuclear Structure and Function
- Endometriosis Research and Treatment
- Eicosanoids and Hypertension Pharmacology
- Neuroendocrine Tumor Research Advances
- Vagus Nerve Stimulation Research
Oregon Health & Science University
2021-2025
University of Portland
2021
Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant transcriptionally diverse population in pancreatic ductal adenocarcinoma (PDAC) thought to arise from a common cell origin, stellate cells (PSC), with diversification resulting cytokine growth factor gradients within tumor microenvironment. Here we analyzed differentiation function PSCs during progression vivo. Contrary...
Metastatic progression defines the final stages of tumor evolution and underlies majority cancer-related deaths. The heterogeneity in disseminated cell populations capable seeding growing distant organ sites contributes to development treatment resistant disease. We recently reported identification a novel tumor-derived population, circulating hybrid cells (CHCs), harboring attributes from both macrophages neoplastic cells, including functional characteristics important metastatic spread....
mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for treating various diseases. While vaccines anticipate immunogenicity, the associated reactogenicity of mRNA-loaded LNPs poses significant challenges, especially protein replacement therapies requiring multiple administrations, leading to adverse effects and suboptimal therapeutic outcomes. Historically, research has primarily focused on cargo, leaving role understudied this context. Adjuvanticity...
Metastatic progression significantly reduces survival rates and complicates treatment strategies in various cancers. Our study introduces an mRNA therapy for metastasis inhibition by targeting activin A overexpression, a pivotal driver of cachexia. Utilizing follistatin lipid nanoparticles, we effectively downregulated both locally the tumor environment systemically. This led to reduction burden suppression metastatic spread murine head neck squamous cell carcinoma model. Treated mice...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a 5-year survival rate 12.8%. This aggressive malignancy composed heterogenous tumor microenvironment (TME), including cancer-associated fibroblasts (CAFs) and sympathetic neurons. The abundance CAFs neurons correlates progression often associated poor prognosis PDAC patients. However, precise role CAF-nerve interactions in cancer metastasis remains unclear. To explore our hypothesis that these...
Hypothalamic inflammation often coincides with cancer and cachexia-anorexia. Prior work established the significance of tumor-derived inflammatory factors in triggering hypothalamic inflammation, yet precise mechanisms remained elusive. Here, we demonstrate that prostaglandin E2 (PGE2), produced tumor via cyclooxygenase-2 (COX-2), plays a pivotal role this context. PGE2 itself directly exerts pro-inflammatory effects on hypothalamus through EP4 receptor, while also augmenting NF-κB pathways...
Abstract Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant transcriptionally diverse population in pancreatic ductal adenocarcinoma (PDAC) thought to arise from a common cell origin, stellate cells (PSCs), with diversification resulting cytokine growth factor gradients within tumor microenvironment. Here we analyzed differentiation function PSCs during progression vivo ....
Abstract Metastatic progression defines the final stages of tumor evolution and underlies majority cancer-related deaths. The heterogeneity in disseminated cell populations capable seeding growing distant organ sites contributes to development treatment resistant disease. We recently reported identification a novel tumor-derived population, circulating hybrid cells (CHCs), harboring attributes from both macrophages neoplastic cells, including functional characteristics important metastatic...
Abstract The pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) is innervated by a variety of peripheral nerves that are emerging as facilitators initiation, progression and metastasis. However, the influences sympathetic on TME how these bi-directional interactions can exacerbate PDAC remains unclear. Sympathetic innervate both human murine tumors frequently surrounded abundant heterogeneous cancer-associated fibroblasts (CAFs), which known to play various crucial roles in...
<div>Abstract<p>Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant transcriptionally diverse population in pancreatic ductal adenocarcinoma (PDAC) thought to arise from a common cell origin, stellate cells (PSC), with diversification resulting cytokine growth factor gradients within tumor microenvironment. Here we analyzed differentiation function PSCs during...
<p>Figures S1-S3</p>
<p>Table S1</p>
<div>Abstract<p>Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the origins and functions of distinct CAF subtypes remain poorly understood. The abundant transcriptionally diverse population in pancreatic ductal adenocarcinoma (PDAC) thought to arise from a common cell origin, stellate cells (PSC), with diversification resulting cytokine growth factor gradients within tumor microenvironment. Here we analyzed differentiation function PSCs during...
<p>Supplementary Methods</p>
<p>Supplementary Methods</p>
<p>Figures S1-S3</p>
<p>Table S2</p>
<p>Table S2</p>
<p>Table S1</p>