A5082766339- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Melanoma and MAPK Pathways
- Cancer and Skin Lesions
- CAR-T cell therapy research
- Optical Coherence Tomography Applications
- AI in cancer detection
- Immunotherapy and Immune Responses
- Cell Image Analysis Techniques
- Allergic Rhinitis and Sensitization
- Surgical Sutures and Adhesives
- Botulinum Toxin and Related Neurological Disorders
- Genetic and rare skin diseases.
- Cancer Immunotherapy and Biomarkers
- Skin Protection and Aging
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Sarcoma Diagnosis and Treatment
- Wound Healing and Treatments
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- vaccines and immunoinformatics approaches
- Genital Health and Disease
University Hospital Carl Gustav Carus
2024
University of Göttingen
2010-2023
Universitätsmedizin Göttingen
2015-2023
Robert Koch Institute
2015-2022
GTx (United States)
2022
University Medical Center
2021
Medizinische Hochschule Hannover
2015
University of Hildesheim
2015
University Hospital Augsburg
2015
Creative Commons
2015
Temozolomide (TMZ) has shown efficacy in metastatic melanoma equal to that of dacarbazine (DTIC), the standard chemotherapeutic agent for melanoma. As combination with interferon-alfa (IFN-alpha) appears superior single-agent DTIC regarding response rates, purpose this study was compare TMZ alone and plus IFN-alpha terms objective (OR), overall survival, safety a prospective, randomized, multicenter trial.Two hundred ninety-four patients untreated stage IV (American Joint Committee on Cancer...
For patients with melanoma metastasis to a sentinel lymph node, subsequent complete regional node dissection (CLND) is currently regarded be the surgical standard. This approach, however, has not been confirmed by controlled studies, so that morbidity of primary importance. Using clinical examination and questionnaire, we determined in 315 axillary or inguinal excision on whom 275 lymphonodectomies (SLNEs) 90 CLNDs were performed. The overall incidence at least one complication following...
BACKGROUND Therapy with vemurafenib, an inhibitor of mutated BRAF, yields a response rate approximately 50% in patients metastatic melanoma harboring BRAF V600E mutation. As adverse effect proliferative disorders keratinocytes, including squamous cell carcinoma, have been described. Low concentration vemurafenib as present the epidermis were found to activate wild-type RAF, which, combination preexisting RAS mutation, can promote keratinocyte proliferation. While activating mutations occur...
The value of the status sentinel lymph node (SLN) in patients with thick melanomas (Breslow thickness > or = 4 mm) is controversial.Using Kaplan-Meier estimates and Cox regression models, we studied 152 primary mm who underwent excision (SLNE) at university hospitals Hannover Göttingen, Germany, between 1998 2006.The median tumor was 5.2 (4-18) mm; 58.5% were ulcerated. Micrometastasis to a SLN found 48.7%. positive SLNs significantly younger than those negative (p 0.01). Of complete...
In our study, we investigated the impact of constitutional factor age on clinical courses melanoma patients with sentinel lymph node (SLN) biopsy. Descriptive statistics, Kaplan-Meier estimates, logistic regression analysis and Cox proportional hazards model were used to study a population 2,268 consecutive from three German centers. Younger was significantly related less advanced primary tumors. Nevertheless, younger than 40 years had twofold risk being SLN-positive (p < 0.000001). Of young...
The present study addresses the question whether an extended ilioinguinal dissection as compared to only superficial inguinal improves survival and/or local tumour control after appearance of palpable melanoma metastases groin. We retrospectively analysed data 104 patients with 69 and 35 dissections (median follow up 127 months). Prognostic factors groin recurrence were assessed using Kaplan-Meier estimation Cox proportional hazards model. By multifactorial analysis, metastatic involvement...
Hybrid cell vaccination with fusion products (CFPs) of autologous tumor cells and mature allogenic MHC II bearing dendritic has been described to induce cytotoxic T lymphocyte (CTL)-mediated immune responses. The aim this study was assess safety, antitumor activity, responses a CFP-vaccine in patients disseminated malignant melanoma. In phase I/II study, we treated 11 by monthly intracutaneous or subcutaneous application CFP vaccine generated electrofusion melanoma cells. addition, received...
Early detection of melanoma metastases is essential for effective treatment and may be crucial the prevention systemic patient survival. However, data demonstrating reliability accuracy ultrasound examination lymph node metastases, in addition to clinical examination, are rare. We have examined 433 patients with stage-dependent follow-up intervals 3 12 months. One thousand three hundred thirty-two paired nonblinded sonographic tests locoregional areas were performed. Lesions suspicious...
Botulinum toxin type A is an effective, well-tolerated, albeit temporary treatment for primary axillary hyperhidrosis. However, little known about the influence of repetitive injections on duration efficacy.139 patients with hyperhidrosis were injected 50 units botulinum per axilla. In 101 patients, who received at least three treatments, efficacy after first, second, and last was evaluated.The median 4.0 months, 4.5 5.0 months injection, respectively. Overall, significantly longer injection...
The objective of this study was to analyze different types nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma.Kaplan-Meier estimates and the Cox proportional hazards model were used 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value SLNB 96.4%. false-negative (FN) rates 1, 2, 3, 5, 10 years 2.5%, 4.6%, 6.4%, 8.7%, 12.6%, respectively. Independent factors associated with false negativity older age, fewer SLNs...
Sentinel lymph node (SN) tumor burden is becoming increasingly important and likely to be included in future N classifications melanoma. Our aim was investigate the prognostic significance of melanoma infiltration various anatomically defined substructures. This retrospective cohort study 1250 consecutive patients with SN biopsy. The pathology protocol required description metastatic each following substructures: intracapsular vessels, subcapsular transverse sinuses, cortex, paracortex,...
The Schimmelpenning-Feuerstein-Mims syndrome (SFM syndrome) is a rare and variable multisystem defect consisting of congenital, extensive linear nevus sebaceus associated abnormalities in different neuroectodermal organ systems. We present the history 52-year-old female patient with disproportionate hyposomia asymmetric constitution. From birth she suffered from right-sided, following Blaschko’s lines extending on scalp, neck, right arm trunk. At age 5 years, developed generalized growth...
BACKGROUND Dermabrasion is one approach to the treatment of treating giant melanocytic congenital nevi. Treatment recommended reduce risk spontaneous malignant transformation nevi into melanomas that usually occur in childhood. OBJECTIVE To describe development a multicentric melanoma nevus after dermabrasion. METHODS We report about 46-year-old male patient who developed nevus. The was located on his left shoulder extending neck and chest. Previously, dermabrasion performed twice at ages 26...
Summary Background: The impact of lymphatic drainage to popliteal sentinel lymph nodes (SLNs) has yet be explored in detail. Patients and Methods: We performed lymphoscintigraphy on 663 patients with cutaneous melanomas. following day lymphonodectomy was performed. SLNs were studied serial sections both histology immunohistochemistry. Results: 166 had a melanoma located the foot, lower leg or knee, i. e., potential nodes. On lymphoscintigraphy, only 16 (9.6 %) showed SLNs. A SLN surgically...