A5019937386- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Autoimmune and Inflammatory Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Wound Healing and Treatments
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Eosinophilic Disorders and Syndromes
- Genetic and rare skin diseases.
- Chemotherapy-related skin toxicity
- AI in cancer detection
- Mesenchymal stem cell research
- Skin and Cellular Biology Research
- Healthcare and Venom Research
- Nail Diseases and Treatments
Universitätsklinikum Würzburg
2014-2024
University of Plymouth
2016
Peninsula Health
2016
University of Würzburg
1999-2013
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie
2011
Olgahospital
1899
BackgroundIn recent studies, convolutional neural networks (CNNs) outperformed dermatologists in distinguishing dermoscopic images of melanoma and nevi. In these artificial intelligence were considered as opponents. However, the combination classifiers frequently yields superior results, both machine learning among humans. this study, we investigated potential benefit combining human for skin cancer classification.MethodsUsing 11,444 images, which divided into five diagnostic categories,...
FADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constitutively lack these molecules die at an early embryonic age, whereas tissue-specific constitutive deletion FADD or caspase-8 results in inflammatory skin disease caused by increased necroptosis. The function vivo is unknown. In contrast to knockout, we show mice lacking epidermis around days 10 11. When expression was abrogated adult cFLIPfl/fl-K14CreERtam mice, severe inflammation with concomitant...
Abstract Background While rapid healing of diabetic foot ulcers (DFUs) is highly desirable to avoid infections, amputations and life-threatening complications, DFUs often respond poorly standard treatment. GMP-manufactured skin-derived ABCB5 + mesenchymal stem cells (MSCs) might provide a new adjunctive DFU treatment, based on their remarkable skin wound homing engraftment potential, ability adaptively inflammatory signals, healing-promoting efficacy in mouse models human chronic venous...
There is an ongoing debate on whether angiotensin-converting enzyme inhibitors (ACEI) should be substituted prior to initiation of venom immunotherapy (VIT) for safety reasons.We aimed assess the influence ACEI medication incidence systemic reactions (SR) during build-up phase VIT in a large and homogeneous cohort patients.The frequency SR 775 consecutive cycles was analyzed relation cardiovascular medication, age, sex, venom, reactivity diagnostic tests, severity preceding sting-induced...
Abstract Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects psoriasis, an inflammatory human disease. Here we show depleted B cells or bearing interleukin (IL)-10-deficient a fulminant upon IMQ exposure, whereas ablation NFATc1 in results suppression Aldara-induced inflammation. In vitro , proliferation and IL-10 expression by is blocked BCR signals inducing NFATc1. By binding HDAC1,...
Background aimsHuman dermal ABCB5-expressing mesenchymal stromal cells (ABCB5+ MSCs) represent a promising candidate for stem cell–based therapy of various currently uncurable diseases in several fields regenerative medicine. We have developed and validated method to isolate, from human skin samples, expand ABCB5+ MSCs that meet the guideline criteria International Society Cellular Therapy. are able process these into Good Manufacturing Practice–conforming, MSC-based advanced-therapy...
The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed three prominent isoforms. This due to alternative splice/polyadenylation events lead the predominant synthesis of two long isoforms naive a shorter isoform effector cells. Whereas previously described NF-ATc/A contains relatively short C terminus, longer isoforms, B C, span extra C-terminal peptides 128 246 aa, respectively. We show here addition strong N-terminal...
Mesenchymal stromal cells (MSCs) hold promise for the treatment of tissue damage and injury. However, MSCs comprise multiple subpopulations with diverse properties, which could explain inconsistent therapeutic outcomes seen among attempts. Recently, adenosine triphosphate-binding cassette transporter ABCB5 has been shown to identify a novel dermal immunomodulatory MSC subpopulation. The authors have established validated Good Manufacturing Practice (GMP)-compliant expansion manufacturing...
A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standard care. Skin-derived ABCB5+ mesenchymal stem cells (MSCs) can dampen the sustained IL-1β-driven inflammation present in wounds. Based on their wound healing-facilitating effects a mouse CVU model and an autologous first-in-human study, MSCs have emerged as potential candidate for cell-based advanced therapy non-healing CVUs. In interventional, multicenter, single-arm, phase I/IIa clinical...
Human keratinocytes undergo apoptosis following treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via surface-expressed TRAIL receptors 1 and 2. In addition, triggers nonapoptotic signaling pathways including activation of the transcription factor NF-κB, in particular when TRAIL-induced is blocked. The intracellular protein cFLIPL interferes at death-inducing complex (DISC) many cell types. To study role signaling, we established stable HaCaT keratinocyte lines...
The lymphocyte transformation test (LTT) has been promoted as in-vitro for diagnosis of drug hypersensitivity. For determination statistical LTT sensitivity, series patients with clinically uniform reactions followed by complete hypersensitivity work-up are mandatory. Assessment specificity requires control who tolerated exposure to the studied.To prospectively determine diagnostic value in a and diagnostically well-defined patients.Patients exanthematous skin eruptions after ampicillin...
Indolent CD8+ cutaneous lymphoid proliferation represents a recently described entity among T-cell lymphomas that typically presents with solitary skin lesions on the face or at acral sites and usually follows an indolent clinical course. Histopathologically, this is characterized by dense dermal infiltrate of non-epidermotropic, small- to medium-sized pleomorphic T-cells non-activated cytotoxic phenotype showing clear-cut grenz zone low index. Distinction from otherwise aggressive bearing...
Summary Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular neoplasm mainly affecting middle‐aged women. Lesions typically affect the head and neck region. ALHE considered distinct disease entity different from Kimura's disease, reactive lymphoid proliferation that predominantly seen in young Asian men although it can all ethnic groups. In contrast to ALHE, associated peripheral blood eosinophilia, increased serum IgE lymphadenopathy. Several case reports suggest an...
The recently proposed entity of cutaneous follicular helper T (T(FH)) cell lymphoma (CT(FH)CL) harbors distinct clinical and histopathologic features. Here, diagnostic pitfalls are exemplified in a case report by review the literature. A 45-year-old patient developed rapidly growing nodules plaques on upper arms buttocks, which were initially misdiagnosed as primary follicle center B-cell (CFCL). Consequently, systemic therapy with rituximab failed consecutive skin biopsies revealed CT(FH)CL...