A5019977537- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Genetic and rare skin diseases.
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders
- Tumors and Oncological Cases
- Systemic Sclerosis and Related Diseases
- Soft tissue tumor case studies
- Polyomavirus and related diseases
- Nail Diseases and Treatments
- Skin Diseases and Diabetes
- Full-Duplex Wireless Communications
- Mast cells and histamine
- Infectious Diseases and Mycology
- Hidradenitis Suppurativa and Treatments
- Chronic Lymphocytic Leukemia Research
- Cutaneous Melanoma Detection and Management
- Fungal Infections and Studies
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Antenna Design and Analysis
- Immunotherapy and Immune Responses
- Neurofibromatosis and Schwannoma Cases
Universitätsklinikum Würzburg
2015-2024
European Neuroendocrine Tumor Society
2022
University of Würzburg
2009-2021
Comprehensive Cancer Center Mainfranken
2020-2021
Austrian Society of Dermatology and Venereology
2018-2020
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie
2013
Bundeskriminalamt
2010
Klinikum Kassel
2007
Aims: To investigate the correlation between centrally assessed human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) results response to treatment of patients with metastatic breast cancer enrolled a first-line, phase II, open-label, 3-weekly trastuzumab (Herceptin) monotherapy trial (WO16229). Methods: Samples from participants WO16229 were collected tumour HER2 status determined by IHC FISH. test interpreted according...
•This ESMO Clinical Practice Guideline provides key recommendations for managing Merkel-cell carcinoma (MCC).•Recommendations are based on available scientific data and the multidisciplinary group of experts' collective opinion.•The guideline covers clinical pathological diagnosis, staging risk assessment, treatment follow-up.•Algorithms management locoregional inoperable/metastatic disease provided.•A team with a high level expertise in MCC should diagnose make decisions about therapy.
Abstract Background Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine cutaneous malignancy with poor prognosis. In Europe, approved systemic therapies are limited to the PD-L1 inhibitor avelumab. For avelumab-refractory patients, efficient safe treatment options lacking. Methods At three different sites in Germany, clinical molecular data of patients metastatic MCC being refractory avelumab who were later on treated combined IPI/NIVO retrospectively collected evaluated....
Merkel cell carcinoma is a rare, highly aggressive skin cancer with neuroendocrine differentiation. Immune checkpoint inhibition has significantly improved treatment outcomes in metastatic disease response rates to programmed death protein 1/programmed 1 ligand (PD-1/PD-L1) of up 62%. However, primary and secondary resistance PD-1/PD-L1 remains so far unsolved clinical challenge since effective safe options for these patients are lacking. Fourteen advanced (non-resectable stage III or IV,...
There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ (Tregs) inflammatory T-helper (Th) 17 has been suggested.The study aimed (1) to investigate phenotypical functional characteristics Th17 Tregs SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) activity, (2) transcriptional level methylation status Th17- Treg-specific transcription...
Indolent CD8+ cutaneous lymphoid proliferation represents a recently described entity among T-cell lymphomas that typically presents with solitary skin lesions on the face or at acral sites and usually follows an indolent clinical course. Histopathologically, this is characterized by dense dermal infiltrate of non-epidermotropic, small- to medium-sized pleomorphic T-cells non-activated cytotoxic phenotype showing clear-cut grenz zone low index. Distinction from otherwise aggressive bearing...
The introduction of new therapeutic agents has revolutionized the treatment metastatic melanoma. approval adjuvant anti-programmed death-1 monotherapy with nivolumab or pembrolizumab, and dabrafenib plus trametinib recently set a landmark in stage III Now, clinical trials have shown that immune checkpoint blockade can be performed neoadjuvant setting, an approach established as standard for other tumour entities such breast cancer. Recent studies suggest pathological response achieved by...
Henoch-Schönlein Purpura (HSP) or IgA vasculitis is the most common systemic of childhood and may affect skin, joints, gastrointestinal tract, kidneys. Skin manifestations HSP are characteristic include a non-thrombocytopenic palpable purpura lower extremities buttocks. Rarely, initially present as evolve into hemorrhagic vesicles bullae. We an otherwise healthy 5-year-old boy with acute papulovesicular rash both legs intermittent abdominal pain. After few days skin lesions rapidly evolved...
In Europe, infections with Mycobacterium (M.) marinum are rare. We conducted a retrospective single-center study to assess the clinical spectrum of M. infection and its diagnosis, treatment outcome under real-world conditions.Eighteen patients presenting between 1998 2018 were identified in data warehouse University Hospital Würzburg considered for detailed analysis.Twelve reported aquatic exposure. 16/18 cases upper extremities affected. No invasive detected. Mean time diagnosis was 15...
Background: Primary cutaneous diffuse large B-cell lymphoma (PCLBCL) represents a rare subtype among primary exhibiting characteristic genetic background, an aggressive clinical course and high relapse rate under different therapeutic regimen. Therefore, PCLBCL has rather restricted prognosis. Patients methods: Four patients with were treated at our institution age- toxicity-adapted first-line immunochemotherapy rituximab modified CHOP (cyclophosphamid, vincristin, liposomal doxorubicin,...
Shiitake (Lentinus edodes) is the second most consumed mushroom in world. It has long been known Asian medicine for its anticarcinogenic, antihypertensive and serum cholesterol level reduction properties. Nevertheless, consumption of raw or not well-cooked mushrooms may cause skin eruptions which usually occur 24 to 48 hours after ingestion are characterized by linearly arranged pruritic erythematous papules plaques. We present a 36-year-old patient that developed typical symptoms shiitake...
Mycosis fungoides, the most common type of cutaneous T-cell lymphoma, can manifest in a variety clinical and histological forms. Bulla formation is an uncommon finding mycosis fungoides only approximately 20 cases have been reported literature.We present case rapidly progressive 68-year-old Caucasian man who initially presented with erythematous plaques characterised by blister formation.Although bullosa extremely rare, it has to be regarded as important subtype lymphoma. represents...
Immune-checkpoint blockade (ICB) shows significant activity in metastatic Merkel cell carcinoma (MCC) but primary resistance remains a major clinical challenge [1.Nghiem P.T. Bhatia S. Lipson E.J. et al.PD-1 with pembrolizumab advanced Merkel-cell carcinoma.N Engl J Med. 2016; 374: 2542-2552Crossref PubMed Scopus (728) Google Scholar, 2.Kaufman H.L. Russell J. Hamid O. al.Avelumab patients chemotherapy-refractory carcinoma: multicentre, single-group, open-label, phase 2 trial.Lancet Oncol....
Systemic sclerosis (SSc) is a predominantly T-cell-mediated autoimmune disorder with characteristic sequence of Th1 and Th2 inflammation resulting in fibrosis. The contribution differentiated memory T-cell subpopulations methylation CpG regions Th1- or Th2-specific transcription factor genes on the inflammatory cytokine signature SSc not well understood. study aimed to investigate phenotypic differentiation, signature, sensitivity T cells vitro suppression by autologous regulatory (Tregs),...
BackgroundNeoadjuvant immune-checkpoint inhibition (neoICI) with ipilimumab and nivolumab has shown high pathologic response rates as well a long-lasting relapse-free survival in stage III melanoma patients. However, safety efficacy data from real-world patients is very limited.MethodsStage IIIB-IV (M1a) macroscopic nodal metastases or without synchronous non-nodal lesions received combined neoICI 1 mg/kg 3 mg/kg. Radiological pathological (RFS), event-free (EFS), overall (OS),...
A proangiogenic micromilieu is associated with a worse prognosis in systemic lymphoma. Hence, targeting the tumour microenvironment and its vasculature has evolved as promising novel treatment strategy. The role of neoangiogenesis cutaneous B-cell lymphoma, however, not yet been elucidated. Therefore, we examined expression vascular endothelial growth factor (VEGF) receptors VEGFR-1 VEGFR-2, well microvessel density by immunohistochemistry paraffin-embedded specimens different subtypes...
Over the last few decades, number of cases non-melanoma skin cancer (NMSC) has risen to over 3 million every year worldwide. Members ERBB receptor family are important regulators development and homeostasis and, when dysregulated, contribute pathogenesis. In this study, we investigated leucine-rich repeats immunoglobulin-like domains 2 (LRIG2), a transmembrane protein involved in feedback loop regulation during NMSC. LRIG2 was identified be up-regulated various types squamous cell carcinoma...
A 90-year-old patient presented with a large cutaneous horn (cornu cutaneum) of nine-year duration arising at her right cheek. The lesion was removed by surgery. Histology reported as cornu cutaneum well-differentiated squamous cell carcinoma its base. Cutaneous is morphological designation for protuberant mass keratin that resembles the an animal. Such lesions appear on sun-exposed skin areas like upper parts face and ears in elderly patients. Large horns (> 1 cm) tend to be more commonly...
Human artificial skin models are increasingly employed as non-animal test platforms for research and medical purposes. However, the overall histopathological quality of such may vary significantly. Therefore, effects manufacturing protocols donor sources on built-up from fibroblasts keratinocytes derived juvenile foreskins is studied. Histo-morphological parameters epidermal thickness, number cell layers, dermal dermo-epidermal adhesion absence cellular nuclei in corneal layer obtained...
The emergence of a common progenitor cell has been postulated for the association CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within same patient. Up to now, no comprehensive analysis yet addressed genetic profiles such concurrent lymphoma subtypes. We aimed delineate molecular alterations clonally related LPD MF occurring in two patients. analyzed profile 16 samples patients suffering both from being obtained over time course at least 5 years. To detect...